Impact of depression on gait variability in Parkinson’s disease
•Depression is associated with gait variability especially in a dual-task condition.•Swing time variability might be particularly sensitive to an impact of depression.•Treating depression is important for improvement of gait and reduction of falls. The goal of this study was to analyze how depressio...
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Veröffentlicht in: | Clinical neurology and neurosurgery 2021-01, Vol.200, p.106324-106324, Article 106324 |
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creator | Dragašević-Mišković, Nataša T Bobić, Vladislava Kostić, Milutin Stanković, Iva Radovanović, Saša Dimitrijević, Kosta Svetel, Marina Petrović, Igor Đurić-Jovičić, Milica |
description | •Depression is associated with gait variability especially in a dual-task condition.•Swing time variability might be particularly sensitive to an impact of depression.•Treating depression is important for improvement of gait and reduction of falls.
The goal of this study was to analyze how depression associated with Parkinson’s disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed.
Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods.
Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients.
Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task.
Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients. |
doi_str_mv | 10.1016/j.clineuro.2020.106324 |
format | Article |
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The goal of this study was to analyze how depression associated with Parkinson’s disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed.
Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods.
Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients.
Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task.
Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.</description><identifier>ISSN: 0303-8467</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/j.clineuro.2020.106324</identifier><identifier>PMID: 33129594</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Cognitive ability ; Depression ; Dual-task paradigm ; Executive function ; Gait ; Gait analysis ; Gait variability ; Mental depression ; Movement disorders ; Neurodegenerative diseases ; Neurology ; Parkinson's disease ; Patients ; Sensors ; Statistical analysis ; Variance analysis ; Walking</subject><ispartof>Clinical neurology and neurosurgery, 2021-01, Vol.200, p.106324-106324, Article 106324</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><rights>2020. Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-89bdc5a90479dae7675555d6458724207257ffe08aed70b8089b1bb53aa823bc3</citedby><cites>FETCH-LOGICAL-c444t-89bdc5a90479dae7675555d6458724207257ffe08aed70b8089b1bb53aa823bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2475350450?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33129594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dragašević-Mišković, Nataša T</creatorcontrib><creatorcontrib>Bobić, Vladislava</creatorcontrib><creatorcontrib>Kostić, Milutin</creatorcontrib><creatorcontrib>Stanković, Iva</creatorcontrib><creatorcontrib>Radovanović, Saša</creatorcontrib><creatorcontrib>Dimitrijević, Kosta</creatorcontrib><creatorcontrib>Svetel, Marina</creatorcontrib><creatorcontrib>Petrović, Igor</creatorcontrib><creatorcontrib>Đurić-Jovičić, Milica</creatorcontrib><title>Impact of depression on gait variability in Parkinson’s disease</title><title>Clinical neurology and neurosurgery</title><addtitle>Clin Neurol Neurosurg</addtitle><description>•Depression is associated with gait variability especially in a dual-task condition.•Swing time variability might be particularly sensitive to an impact of depression.•Treating depression is important for improvement of gait and reduction of falls.
The goal of this study was to analyze how depression associated with Parkinson’s disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed.
Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods.
Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients.
Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task.
Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.</description><subject>Cognitive ability</subject><subject>Depression</subject><subject>Dual-task paradigm</subject><subject>Executive function</subject><subject>Gait</subject><subject>Gait analysis</subject><subject>Gait variability</subject><subject>Mental depression</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Sensors</subject><subject>Statistical analysis</subject><subject>Variance analysis</subject><subject>Walking</subject><issn>0303-8467</issn><issn>1872-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkM1KxDAQx4Mouq6-ghS8eOma5rs3RfwCQQ96DmkylazdZk1aYW--hq_nk5hl1YMXw0Bg-P1nhh9CRxWeVbgSp_OZ7XwPYwwzgsm6KShhW2hSKUlKUQu1jSaYYloqJuQe2k9pjjGmVKhdtEdpRWpeswk6v10sjR2K0BYOlhFS8qEvcj0bPxRvJnrT-M4Pq8L3xYOJL75Pof98_0iF8wlMggO005ouweH3P0VPV5ePFzfl3f317cX5XWkZY0Op6sZZbmrMZO0MSCF5fk4wng9mBEvCZdsCVgacxI3COVA1DafGKEIbS6foZDN3GcPrCGnQC58sdJ3pIYxJE8aFEhXP9BQd_0HnYYx9vi5TklOOGceZEhvKxpBShFYvo1-YuNIV1mvJeq5_JOu1ZL2RnINH3-PHZgHuN_ZjNQNnGwCyjzcPUSfrobfgfAQ7aBf8fzu-AC1qkFg</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Dragašević-Mišković, Nataša T</creator><creator>Bobić, Vladislava</creator><creator>Kostić, Milutin</creator><creator>Stanković, Iva</creator><creator>Radovanović, Saša</creator><creator>Dimitrijević, Kosta</creator><creator>Svetel, Marina</creator><creator>Petrović, Igor</creator><creator>Đurić-Jovičić, Milica</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>202101</creationdate><title>Impact of depression on gait variability in Parkinson’s disease</title><author>Dragašević-Mišković, Nataša T ; Bobić, Vladislava ; Kostić, Milutin ; Stanković, Iva ; Radovanović, Saša ; Dimitrijević, Kosta ; Svetel, Marina ; Petrović, Igor ; Đurić-Jovičić, Milica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-89bdc5a90479dae7675555d6458724207257ffe08aed70b8089b1bb53aa823bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cognitive ability</topic><topic>Depression</topic><topic>Dual-task paradigm</topic><topic>Executive function</topic><topic>Gait</topic><topic>Gait analysis</topic><topic>Gait variability</topic><topic>Mental depression</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Neurology</topic><topic>Parkinson's disease</topic><topic>Patients</topic><topic>Sensors</topic><topic>Statistical analysis</topic><topic>Variance analysis</topic><topic>Walking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dragašević-Mišković, Nataša T</creatorcontrib><creatorcontrib>Bobić, Vladislava</creatorcontrib><creatorcontrib>Kostić, Milutin</creatorcontrib><creatorcontrib>Stanković, Iva</creatorcontrib><creatorcontrib>Radovanović, Saša</creatorcontrib><creatorcontrib>Dimitrijević, Kosta</creatorcontrib><creatorcontrib>Svetel, Marina</creatorcontrib><creatorcontrib>Petrović, Igor</creatorcontrib><creatorcontrib>Đurić-Jovičić, Milica</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurology and neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dragašević-Mišković, Nataša T</au><au>Bobić, Vladislava</au><au>Kostić, Milutin</au><au>Stanković, Iva</au><au>Radovanović, Saša</au><au>Dimitrijević, Kosta</au><au>Svetel, Marina</au><au>Petrović, Igor</au><au>Đurić-Jovičić, Milica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of depression on gait variability in Parkinson’s disease</atitle><jtitle>Clinical neurology and neurosurgery</jtitle><addtitle>Clin Neurol Neurosurg</addtitle><date>2021-01</date><risdate>2021</risdate><volume>200</volume><spage>106324</spage><epage>106324</epage><pages>106324-106324</pages><artnum>106324</artnum><issn>0303-8467</issn><eissn>1872-6968</eissn><abstract>•Depression is associated with gait variability especially in a dual-task condition.•Swing time variability might be particularly sensitive to an impact of depression.•Treating depression is important for improvement of gait and reduction of falls.
The goal of this study was to analyze how depression associated with Parkinson’s disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed.
Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods.
Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients.
Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task.
Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33129594</pmid><doi>10.1016/j.clineuro.2020.106324</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Cognitive ability Depression Dual-task paradigm Executive function Gait Gait analysis Gait variability Mental depression Movement disorders Neurodegenerative diseases Neurology Parkinson's disease Patients Sensors Statistical analysis Variance analysis Walking |
title | Impact of depression on gait variability in Parkinson’s disease |
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