Emerging mechanisms contributing to mast cell-mediated pathophysiology with therapeutic implications

Mast cells are tissue-resident immune cells that play key roles in the initiation and perpetuation of allergic inflammation, usually through IgE-mediated mechanisms. Mast cells are, however, evolutionary ancient immune cells that can be traced back to urochordates and before the emergence of IgE ant...

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 2021-04, Vol.220, p.107718-107718, Article 107718
Hauptverfasser:	Falduto, Guido H., Pfeiffer, Annika, Luker, Andrea, Metcalfe, Dean D., Olivera, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy Extracellular vesicles Humans Immunoglobulin E Inflammation - drug therapy Mast cell Mast cell activation Mast cell targeting Mast Cells - pathology Mastocytosis Receptors, G-Protein-Coupled
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