Noradrenergic fibers are associated with beta-cell dedifferentiation and impaired beta-cell function in humans

Type 2 diabetes (T2D) is characterized by a progressive loss of beta-cell function, and the “disappearance” of beta-cells in T2D may also be caused by the process of beta -cell dedifferentiation. Since noradrenergic innervation inhibits insulin secretion and density of noradrenergic fibers is increa...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2021-01, Vol.114, p.154414-154414, Article 154414
Hauptverfasser:	Cinti, F., Mezza, T., Severi, I., Suleiman, M., Cefalo, C.M.A., Sorice, G.P., Moffa, S., Impronta, F., Quero, G., Alfieri, S., Mari, A., Pontecorvi, A., Marselli, L., Cinti, S., Marchetti, P., Giaccari, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Neurons - physiology Aged Beta cell failure Blood Glucose - metabolism Cell Dedifferentiation - physiology Dedifferentiation Diabetes Mellitus, Type 2 - metabolism Female Glucose Intolerance - metabolism Glyburide - metabolism Human type 2 diabetes mellitus Humans Innervation Insulin - metabolism Insulin Secretion - physiology Insulin-Secreting Cells - metabolism Islets of Langerhans - metabolism Male Middle Aged Nerve Fibers - physiology Personalized medicine
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