Synthesis and biological evaluation of indolylglyoxylamide bisphosphonates, antimitotic microtubule-targeting derivatives of indibulin with improved aqueous solubility

[Display omitted] Indibulin (D-24851) derivatives with bisphosphonate fragment connected to the N1 atom of imidazole ring were synthesized by alkylation of (indolyl-3)methylglyoxylates with ethylenebisphosphonate. Biological evaluation of targeted compounds 4a–d using the phenotypic sea urchin embry...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2020-12, Vol.30 (23), p.127635-127635, Article 127635
Hauptverfasser:	Brel, Valery K., Artyushin, Oleg I., Chuprov-Netochin, Roman N., Leonov, Sergey V., Semenova, Marina N., Semenov, Victor V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bisphosphonates Indibulin Indolylglyoxylamides Microtubule destabilization Sea urchin embryo
Online-Zugang:	Volltext
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