Protective Effect of Epalrestat against Oxidative Stress-induced Cytotoxicity

Epalrestat (EPS), approved in Japan, is currently the only aldose reductase inhibitor that is available for the treatment of diabetic neuropathy. Recently, we found that EPS at near-plasma concentration increases the intracellular levels of glutathione (GSH) in rat Schwann cells. GSH, the most abund...

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Veröffentlicht in:	YAKUGAKU ZASSHI 2020/11/01, Vol.140(11), pp.1381-1388
Hauptverfasser:	Tatsunami, Ryosuke, Murao, Yu, Sato, Keisuke
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	cytotoxicity epalrestat oxidative stress reactive oxygen species
Online-Zugang:	Volltext
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