Improvement of autophagy dysfunction as a potential mechanism for environmental enrichment to protect blood-brain barrier in rats with vascular cognitive impairment

•Environmental enrichment (EE) can attenuate cognitive decline in chronic cerebral hypoperfusion (CCH) rats.•EE can ameliorate blood-brain barrier (BBB) injury caused by CCH.•EE can improve the autophagy dysfunction, which may mediate the protective effect of EE on BBB. Vascular cognitive impairment...

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Veröffentlicht in:	Neuroscience letters 2020-11, Vol.739, p.135437-135437, Article 135437
Hauptverfasser:	Xu, Linling, Qu, Changhua, Qu, Chujie, Shen, Jun, Song, Hao, Li, Yaqing, Li, Tian, Zheng, Jiaxin, Zhang, Junjian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Blood-brain barrier Blood-Brain Barrier - pathology Chronic cerebral hypoperfusion Cognitive Dysfunction - pathology Cognitive Dysfunction - physiopathology Cognitive Dysfunction - prevention & control Cognitive impairment Dementia, Vascular - pathology Dementia, Vascular - physiopathology Dementia, Vascular - psychology Environment Environmental enrichment Hippocampus - ultrastructure Male Maze Learning Neurons - ultrastructure Rats, Sprague-Dawley
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