Hepatitis E viral infection regulates estrogen signaling pathways: Inhibition of the cAMPK–PKA–CREB and PI3K–AKT–mTOR signaling pathways

Hepatitis E virus (HEV) infection has become a global concern with high mortality rates among pregnant women, especially those in their third trimester of pregnancy. Estrogen plays an important role in mediating the body, regulating physiological and pathological processes. Estrogen is activated by...

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Veröffentlicht in:	Journal of medical virology 2021-06, Vol.93 (6), p.3769-3778
Hauptverfasser:	Gong, Shilin, Hao, Xianhui, Bi, Yanhong, Yang, Chenchen, Wang, Wenjing, Mickael, Houfack K., Zhang, Yike, Chen, Shuangfeng, Qian, Zhongyao, Huang, Fen, Wei, Daqiao, Yu, Wenhai
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein cAMP–PKA–CREB Cyclic AMP response element-binding protein estro Estrogen receptors estrogen signaling pathway Estrogens gen receptor Hepatitis hepatitis E virus Infections PI3K–AKT–mTOR Pregnancy Protein kinase A Raf protein Replication Signal transduction Signaling TOR protein Virology Viruses
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