Mangiferin protect oxidative stress against deoxynivalenol induced damages through Nrf2 signalling pathways in endothelial cells
Several cereal grains contain a mycotoxin food contaminant called deoxynivalenol (DON), which presents a significant health risk as it is one of the most commonly found mycotoxins. The current paper examines the ameliorative effect of mangiferin (MAN) in vascular endothelial cells induced through ac...
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| Veröffentlicht in: | Clinical and experimental pharmacology & physiology 2021-03, Vol.48 (3), p.389-400 |
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| description | Several cereal grains contain a mycotoxin food contaminant called deoxynivalenol (DON), which presents a significant health risk as it is one of the most commonly found mycotoxins. The current paper examines the ameliorative effect of mangiferin (MAN) in vascular endothelial cells induced through activating the Nrf2 signalling pathway on dietary DON‐induced oxidative changes. The study infers that the intercellular reactive oxygen species (ROS) levels and malondialdehyde decrease due to MAN. Other effects include in human umbilical vein endothelial cells (HUVECs), the oxidative stress‐induced cell damage is reduced due to protective effects and superoxide dismutase (SOD), and catalase (CAT) activities also reveal an improvement. In HUVECs, the Nrf2‐regulated antioxidant enzyme genes' expression is activated by Nrf2 nuclear translocation induction and this activity suppresses the oxidative stress damage. The genes in HUVECs include HO‐1 and NQO1. Moreover, in HUVECs, the nucleus translocation of Nrf2 reduces the Nrf2, HO‐1, whereas NQO1 expression decreases the cytoprotective effects against oxidative stress reduce with the rejection of Nrf2 with siRNA. This paper pioneers in inferring that oxidative stress‐induced HUVECs' cell injury is suppressed by MAN through Nrf2, signalling pathway activation.
Deoxynivalenol induced oxidative stress in endothelial cells. Mangiferin to inhibited oxidative stress via NrF2 |
| doi_str_mv | 10.1111/1440-1681.13432 |
| format | Article |
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Deoxynivalenol induced oxidative stress in endothelial cells. Mangiferin to inhibited oxidative stress via NrF2</description><identifier>ISSN: 0305-1870</identifier><identifier>ISSN: 1440-1681</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1111/1440-1681.13432</identifier><identifier>PMID: 33124065</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Antioxidants ; Antioxidants - pharmacology ; Catalase ; Cell injury ; Contaminants ; Damage ; Deoxynivalenol ; Diet ; Endothelial cells ; Food contamination ; Gene expression ; Genes ; Health risks ; Human Umbilical Vein Endothelial Cells - drug effects ; Human Umbilical Vein Endothelial Cells - metabolism ; Humans ; Malondialdehyde ; mangiferin ; mycotoxin ; Mycotoxins ; NF-E2-Related Factor 2 - metabolism ; Nuclear transport ; Oxidation ; Oxidative stress ; Oxidative Stress - drug effects ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Signal transduction ; Signal Transduction - drug effects ; Signaling ; siRNA ; Superoxide dismutase ; Translocation ; Trichothecenes - toxicity ; Umbilical vein ; Xanthones - pharmacology</subject><ispartof>Clinical and experimental pharmacology & physiology, 2021-03, Vol.48 (3), p.389-400</ispartof><rights>2020 John Wiley & Sons Australia, Ltd</rights><rights>2020 John Wiley & Sons Australia, Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3712-59f299a1937b69900652d71391a55fd285c7d9c5805023d621256c454f735db33</citedby><cites>FETCH-LOGICAL-c3712-59f299a1937b69900652d71391a55fd285c7d9c5805023d621256c454f735db33</cites><orcidid>0000-0003-0932-6261</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1440-1681.13432$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1440-1681.13432$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33124065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al‐Saeedi, Fatma J.</creatorcontrib><title>Mangiferin protect oxidative stress against deoxynivalenol induced damages through Nrf2 signalling pathways in endothelial cells</title><title>Clinical and experimental pharmacology & physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>Several cereal grains contain a mycotoxin food contaminant called deoxynivalenol (DON), which presents a significant health risk as it is one of the most commonly found mycotoxins. The current paper examines the ameliorative effect of mangiferin (MAN) in vascular endothelial cells induced through activating the Nrf2 signalling pathway on dietary DON‐induced oxidative changes. The study infers that the intercellular reactive oxygen species (ROS) levels and malondialdehyde decrease due to MAN. Other effects include in human umbilical vein endothelial cells (HUVECs), the oxidative stress‐induced cell damage is reduced due to protective effects and superoxide dismutase (SOD), and catalase (CAT) activities also reveal an improvement. In HUVECs, the Nrf2‐regulated antioxidant enzyme genes' expression is activated by Nrf2 nuclear translocation induction and this activity suppresses the oxidative stress damage. The genes in HUVECs include HO‐1 and NQO1. Moreover, in HUVECs, the nucleus translocation of Nrf2 reduces the Nrf2, HO‐1, whereas NQO1 expression decreases the cytoprotective effects against oxidative stress reduce with the rejection of Nrf2 with siRNA. This paper pioneers in inferring that oxidative stress‐induced HUVECs' cell injury is suppressed by MAN through Nrf2, signalling pathway activation.
Deoxynivalenol induced oxidative stress in endothelial cells. Mangiferin to inhibited oxidative stress via NrF2</description><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Catalase</subject><subject>Cell injury</subject><subject>Contaminants</subject><subject>Damage</subject><subject>Deoxynivalenol</subject><subject>Diet</subject><subject>Endothelial cells</subject><subject>Food contamination</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Health risks</subject><subject>Human Umbilical Vein Endothelial Cells - drug effects</subject><subject>Human Umbilical Vein Endothelial Cells - metabolism</subject><subject>Humans</subject><subject>Malondialdehyde</subject><subject>mangiferin</subject><subject>mycotoxin</subject><subject>Mycotoxins</subject><subject>NF-E2-Related Factor 2 - metabolism</subject><subject>Nuclear transport</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Signal transduction</subject><subject>Signal Transduction - drug effects</subject><subject>Signaling</subject><subject>siRNA</subject><subject>Superoxide dismutase</subject><subject>Translocation</subject><subject>Trichothecenes - toxicity</subject><subject>Umbilical vein</subject><subject>Xanthones - pharmacology</subject><issn>0305-1870</issn><issn>1440-1681</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtPHDEURq0oUdhA6nSRpTQ0A36MZ8ZltOIlQZIi1JZ3fGfWyGtvbA-wHT8dT5ZQ0MTNlaxzP91PB6EvlJzQ8k5pXZOKNh09obzm7B1avP68RwvCiaho15ID9CmlO0KIIA3_iA44p6wmjVigpxvtRztAtB5vY8jQZxwerdHZ3gNOOUJKWI_a-pSxgfC48_ZeO_DBYevN1IPBRm_0CAnndQzTuMY_4sBwsqPXzlk_4q3O6we9S2UBgzchr8FZ7XAPzqUj9GHQLsHnl3mIbs_Pfi8vq-ufF1fL79dVz1vKKiEHJqWmkrerRkpSjmempVxSLcRgWCf61shedKUi46ZhlImmr0U9tFyYFeeH6HifW1r-mSBltbFpvkB7CFNSrBZNTWUn24J-e4PehSmWNjMlSUcokaJQp3uqjyGlCIPaRrvRcacoUbMcNatQswr1V07Z-PqSO602YF75fzYKIPbAg3Ww-1-eWp792gc_A0mKmRI</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Al‐Saeedi, Fatma J.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0932-6261</orcidid></search><sort><creationdate>202103</creationdate><title>Mangiferin protect oxidative stress against deoxynivalenol induced damages through Nrf2 signalling pathways in endothelial cells</title><author>Al‐Saeedi, Fatma J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3712-59f299a1937b69900652d71391a55fd285c7d9c5805023d621256c454f735db33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Catalase</topic><topic>Cell injury</topic><topic>Contaminants</topic><topic>Damage</topic><topic>Deoxynivalenol</topic><topic>Diet</topic><topic>Endothelial cells</topic><topic>Food contamination</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Health risks</topic><topic>Human Umbilical Vein Endothelial Cells - drug effects</topic><topic>Human Umbilical Vein Endothelial Cells - metabolism</topic><topic>Humans</topic><topic>Malondialdehyde</topic><topic>mangiferin</topic><topic>mycotoxin</topic><topic>Mycotoxins</topic><topic>NF-E2-Related Factor 2 - metabolism</topic><topic>Nuclear transport</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Signal transduction</topic><topic>Signal Transduction - drug effects</topic><topic>Signaling</topic><topic>siRNA</topic><topic>Superoxide dismutase</topic><topic>Translocation</topic><topic>Trichothecenes - toxicity</topic><topic>Umbilical vein</topic><topic>Xanthones - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al‐Saeedi, Fatma J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental pharmacology & physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al‐Saeedi, Fatma J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mangiferin protect oxidative stress against deoxynivalenol induced damages through Nrf2 signalling pathways in endothelial cells</atitle><jtitle>Clinical and experimental pharmacology & physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>2021-03</date><risdate>2021</risdate><volume>48</volume><issue>3</issue><spage>389</spage><epage>400</epage><pages>389-400</pages><issn>0305-1870</issn><issn>1440-1681</issn><eissn>1440-1681</eissn><abstract>Several cereal grains contain a mycotoxin food contaminant called deoxynivalenol (DON), which presents a significant health risk as it is one of the most commonly found mycotoxins. The current paper examines the ameliorative effect of mangiferin (MAN) in vascular endothelial cells induced through activating the Nrf2 signalling pathway on dietary DON‐induced oxidative changes. The study infers that the intercellular reactive oxygen species (ROS) levels and malondialdehyde decrease due to MAN. Other effects include in human umbilical vein endothelial cells (HUVECs), the oxidative stress‐induced cell damage is reduced due to protective effects and superoxide dismutase (SOD), and catalase (CAT) activities also reveal an improvement. In HUVECs, the Nrf2‐regulated antioxidant enzyme genes' expression is activated by Nrf2 nuclear translocation induction and this activity suppresses the oxidative stress damage. The genes in HUVECs include HO‐1 and NQO1. Moreover, in HUVECs, the nucleus translocation of Nrf2 reduces the Nrf2, HO‐1, whereas NQO1 expression decreases the cytoprotective effects against oxidative stress reduce with the rejection of Nrf2 with siRNA. This paper pioneers in inferring that oxidative stress‐induced HUVECs' cell injury is suppressed by MAN through Nrf2, signalling pathway activation.
Deoxynivalenol induced oxidative stress in endothelial cells. Mangiferin to inhibited oxidative stress via NrF2</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33124065</pmid><doi>10.1111/1440-1681.13432</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-0932-6261</orcidid></addata></record> |
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| subjects | Antioxidants Antioxidants - pharmacology Catalase Cell injury Contaminants Damage Deoxynivalenol Diet Endothelial cells Food contamination Gene expression Genes Health risks Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Malondialdehyde mangiferin mycotoxin Mycotoxins NF-E2-Related Factor 2 - metabolism Nuclear transport Oxidation Oxidative stress Oxidative Stress - drug effects Reactive oxygen species Reactive Oxygen Species - metabolism Signal transduction Signal Transduction - drug effects Signaling siRNA Superoxide dismutase Translocation Trichothecenes - toxicity Umbilical vein Xanthones - pharmacology |
| title | Mangiferin protect oxidative stress against deoxynivalenol induced damages through Nrf2 signalling pathways in endothelial cells |
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