Antinociceptive and sedative activity of Vernonia patula and predictive interactions of its phenolic compounds with the cannabinoid type 1 receptor
When tested in the acetic acid‐induced writhing and formalin‐induced paw‐licking tests, the ethanol extract of Vernonia patula (VP) aerial parts showed significant antinociceptive activity. In neuropharmacological tests, it also significantly delayed the onset of sleep, increased the duration of sle...
Gespeichert in:
| Veröffentlicht in: | Phytotherapy research 2021-02, Vol.35 (2), p.1069-1079 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1079 |
|---|---|
| container_issue | 2 |
| container_start_page | 1069 |
| container_title | Phytotherapy research |
| container_volume | 35 |
| creator | Siraj, Md Afjalus Howlader, Md Sariful Islam Rahaman, Md Sohanur Shilpi, Jamil A. Seidel, Veronique |
| description | When tested in the acetic acid‐induced writhing and formalin‐induced paw‐licking tests, the ethanol extract of Vernonia patula (VP) aerial parts showed significant antinociceptive activity. In neuropharmacological tests, it also significantly delayed the onset of sleep, increased the duration of sleeping time, and significantly reduced the locomotor activity and exploratory behaviour of mice. Five phenolic compounds, namely gallic acid, vanillic acid, caffeic acid, quercetin and kaempferol, were detected in VP following HPLC‐DAD analysis. The presence of these phenolic compounds in VP provides some support for the observed antinociceptive and sedative effects. A computational study was performed to predict the binding affinity of gallic acid, vanillic acid, caffeic acid, quercetin and kaempferol towards the cannabinoid type 1 (CB1) receptor. Caffeic and vanillic acid showed the highest probable ligand efficiency indices towards the CB1 target. Vanillic acid displayed the best blood–brain barrier penetration prediction score. These findings provide some evidence for the traditional use of VP to treat pain. |
| doi_str_mv | 10.1002/ptr.6876 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2456418936</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2456418936</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3836-b99819e903f2f77d312708782327f62b71d2e96f5904f1c7e18fb2e6ebf6add13</originalsourceid><addsrcrecordid>eNp10V1rFDEUBuAgFrtWwV8gAW-8mTYfM8nkshS_oGCRKt4NmeSETZlNxiRj2d_hHzazWxWEXh0CD29O8iL0ipJzSgi7mEs6F70UT9CGEqUa2kn-FG2I6mjT0v77KXqe8x0hRDHSPkOnnFPWUtFu0K_LUHyIxhuYi_8JWAeLM1h9PJg6fNnj6PA3SCEGr_GsyzLpA5wTWG8O1IcCafUx5JX7kvG8hRAnb7CJuzkuwWZ878sWly1go0PQY73aW1z2M2CKE6xLxPQCnTg9ZXj5MM_Q1_fvbq8-NtefP3y6urxuDO-5aEaleqpAEe6Yk9LWN0nSy55xJp1go6SWgRKuU6R11EigvRsZCBid0NZSfobeHnPnFH8skMuw89nANOkAcckDaztRf09xUemb_-hdXFKo21WlWCeEouJfoEkx5wRumJPf6bQfKBnWooZa1LAWVenrh8Bl3IH9C_80U0FzBPd-gv2jQcPN7ZdD4G_pCJ8U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2492566916</pqid></control><display><type>article</type><title>Antinociceptive and sedative activity of Vernonia patula and predictive interactions of its phenolic compounds with the cannabinoid type 1 receptor</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Siraj, Md Afjalus ; Howlader, Md Sariful Islam ; Rahaman, Md Sohanur ; Shilpi, Jamil A. ; Seidel, Veronique</creator><creatorcontrib>Siraj, Md Afjalus ; Howlader, Md Sariful Islam ; Rahaman, Md Sohanur ; Shilpi, Jamil A. ; Seidel, Veronique</creatorcontrib><description>When tested in the acetic acid‐induced writhing and formalin‐induced paw‐licking tests, the ethanol extract of Vernonia patula (VP) aerial parts showed significant antinociceptive activity. In neuropharmacological tests, it also significantly delayed the onset of sleep, increased the duration of sleeping time, and significantly reduced the locomotor activity and exploratory behaviour of mice. Five phenolic compounds, namely gallic acid, vanillic acid, caffeic acid, quercetin and kaempferol, were detected in VP following HPLC‐DAD analysis. The presence of these phenolic compounds in VP provides some support for the observed antinociceptive and sedative effects. A computational study was performed to predict the binding affinity of gallic acid, vanillic acid, caffeic acid, quercetin and kaempferol towards the cannabinoid type 1 (CB1) receptor. Caffeic and vanillic acid showed the highest probable ligand efficiency indices towards the CB1 target. Vanillic acid displayed the best blood–brain barrier penetration prediction score. These findings provide some evidence for the traditional use of VP to treat pain.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.6876</identifier><identifier>PMID: 33124164</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Acetic acid ; Acids ; Analgesics - pharmacology ; Analgesics - therapeutic use ; Animals ; antinociceptive activity ; Blood-brain barrier ; Caffeic acid ; Cannabinoid CB1 receptors ; cannabinoid receptor 1 (CB1) ; Cannabinoids - pharmacology ; Cannabinoids - therapeutic use ; Computational neuroscience ; Ethanol ; Exploratory behavior ; Gallic acid ; High-performance liquid chromatography ; Hypnotics and Sedatives - pharmacology ; Hypnotics and Sedatives - therapeutic use ; Kaempferol ; Liquid chromatography ; Locomotor activity ; Male ; Mice ; molecular docking ; Pain ; Pain perception ; Phenols ; Phenols - pharmacology ; Phenols - therapeutic use ; Plant Extracts - chemistry ; Quercetin ; Receptors ; Sleep ; Vanillic acid ; Vernonia ; Vernonia - chemistry ; Vernonia patula</subject><ispartof>Phytotherapy research, 2021-02, Vol.35 (2), p.1069-1079</ispartof><rights>2020 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2020 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3836-b99819e903f2f77d312708782327f62b71d2e96f5904f1c7e18fb2e6ebf6add13</citedby><cites>FETCH-LOGICAL-c3836-b99819e903f2f77d312708782327f62b71d2e96f5904f1c7e18fb2e6ebf6add13</cites><orcidid>0000-0003-3880-5261 ; 0000-0001-8159-1698</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.6876$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.6876$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33124164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siraj, Md Afjalus</creatorcontrib><creatorcontrib>Howlader, Md Sariful Islam</creatorcontrib><creatorcontrib>Rahaman, Md Sohanur</creatorcontrib><creatorcontrib>Shilpi, Jamil A.</creatorcontrib><creatorcontrib>Seidel, Veronique</creatorcontrib><title>Antinociceptive and sedative activity of Vernonia patula and predictive interactions of its phenolic compounds with the cannabinoid type 1 receptor</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>When tested in the acetic acid‐induced writhing and formalin‐induced paw‐licking tests, the ethanol extract of Vernonia patula (VP) aerial parts showed significant antinociceptive activity. In neuropharmacological tests, it also significantly delayed the onset of sleep, increased the duration of sleeping time, and significantly reduced the locomotor activity and exploratory behaviour of mice. Five phenolic compounds, namely gallic acid, vanillic acid, caffeic acid, quercetin and kaempferol, were detected in VP following HPLC‐DAD analysis. The presence of these phenolic compounds in VP provides some support for the observed antinociceptive and sedative effects. A computational study was performed to predict the binding affinity of gallic acid, vanillic acid, caffeic acid, quercetin and kaempferol towards the cannabinoid type 1 (CB1) receptor. Caffeic and vanillic acid showed the highest probable ligand efficiency indices towards the CB1 target. Vanillic acid displayed the best blood–brain barrier penetration prediction score. These findings provide some evidence for the traditional use of VP to treat pain.</description><subject>Acetic acid</subject><subject>Acids</subject><subject>Analgesics - pharmacology</subject><subject>Analgesics - therapeutic use</subject><subject>Animals</subject><subject>antinociceptive activity</subject><subject>Blood-brain barrier</subject><subject>Caffeic acid</subject><subject>Cannabinoid CB1 receptors</subject><subject>cannabinoid receptor 1 (CB1)</subject><subject>Cannabinoids - pharmacology</subject><subject>Cannabinoids - therapeutic use</subject><subject>Computational neuroscience</subject><subject>Ethanol</subject><subject>Exploratory behavior</subject><subject>Gallic acid</subject><subject>High-performance liquid chromatography</subject><subject>Hypnotics and Sedatives - pharmacology</subject><subject>Hypnotics and Sedatives - therapeutic use</subject><subject>Kaempferol</subject><subject>Liquid chromatography</subject><subject>Locomotor activity</subject><subject>Male</subject><subject>Mice</subject><subject>molecular docking</subject><subject>Pain</subject><subject>Pain perception</subject><subject>Phenols</subject><subject>Phenols - pharmacology</subject><subject>Phenols - therapeutic use</subject><subject>Plant Extracts - chemistry</subject><subject>Quercetin</subject><subject>Receptors</subject><subject>Sleep</subject><subject>Vanillic acid</subject><subject>Vernonia</subject><subject>Vernonia - chemistry</subject><subject>Vernonia patula</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp10V1rFDEUBuAgFrtWwV8gAW-8mTYfM8nkshS_oGCRKt4NmeSETZlNxiRj2d_hHzazWxWEXh0CD29O8iL0ipJzSgi7mEs6F70UT9CGEqUa2kn-FG2I6mjT0v77KXqe8x0hRDHSPkOnnFPWUtFu0K_LUHyIxhuYi_8JWAeLM1h9PJg6fNnj6PA3SCEGr_GsyzLpA5wTWG8O1IcCafUx5JX7kvG8hRAnb7CJuzkuwWZ878sWly1go0PQY73aW1z2M2CKE6xLxPQCnTg9ZXj5MM_Q1_fvbq8-NtefP3y6urxuDO-5aEaleqpAEe6Yk9LWN0nSy55xJp1go6SWgRKuU6R11EigvRsZCBid0NZSfobeHnPnFH8skMuw89nANOkAcckDaztRf09xUemb_-hdXFKo21WlWCeEouJfoEkx5wRumJPf6bQfKBnWooZa1LAWVenrh8Bl3IH9C_80U0FzBPd-gv2jQcPN7ZdD4G_pCJ8U</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Siraj, Md Afjalus</creator><creator>Howlader, Md Sariful Islam</creator><creator>Rahaman, Md Sohanur</creator><creator>Shilpi, Jamil A.</creator><creator>Seidel, Veronique</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3880-5261</orcidid><orcidid>https://orcid.org/0000-0001-8159-1698</orcidid></search><sort><creationdate>202102</creationdate><title>Antinociceptive and sedative activity of Vernonia patula and predictive interactions of its phenolic compounds with the cannabinoid type 1 receptor</title><author>Siraj, Md Afjalus ; Howlader, Md Sariful Islam ; Rahaman, Md Sohanur ; Shilpi, Jamil A. ; Seidel, Veronique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3836-b99819e903f2f77d312708782327f62b71d2e96f5904f1c7e18fb2e6ebf6add13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acetic acid</topic><topic>Acids</topic><topic>Analgesics - pharmacology</topic><topic>Analgesics - therapeutic use</topic><topic>Animals</topic><topic>antinociceptive activity</topic><topic>Blood-brain barrier</topic><topic>Caffeic acid</topic><topic>Cannabinoid CB1 receptors</topic><topic>cannabinoid receptor 1 (CB1)</topic><topic>Cannabinoids - pharmacology</topic><topic>Cannabinoids - therapeutic use</topic><topic>Computational neuroscience</topic><topic>Ethanol</topic><topic>Exploratory behavior</topic><topic>Gallic acid</topic><topic>High-performance liquid chromatography</topic><topic>Hypnotics and Sedatives - pharmacology</topic><topic>Hypnotics and Sedatives - therapeutic use</topic><topic>Kaempferol</topic><topic>Liquid chromatography</topic><topic>Locomotor activity</topic><topic>Male</topic><topic>Mice</topic><topic>molecular docking</topic><topic>Pain</topic><topic>Pain perception</topic><topic>Phenols</topic><topic>Phenols - pharmacology</topic><topic>Phenols - therapeutic use</topic><topic>Plant Extracts - chemistry</topic><topic>Quercetin</topic><topic>Receptors</topic><topic>Sleep</topic><topic>Vanillic acid</topic><topic>Vernonia</topic><topic>Vernonia - chemistry</topic><topic>Vernonia patula</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siraj, Md Afjalus</creatorcontrib><creatorcontrib>Howlader, Md Sariful Islam</creatorcontrib><creatorcontrib>Rahaman, Md Sohanur</creatorcontrib><creatorcontrib>Shilpi, Jamil A.</creatorcontrib><creatorcontrib>Seidel, Veronique</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siraj, Md Afjalus</au><au>Howlader, Md Sariful Islam</au><au>Rahaman, Md Sohanur</au><au>Shilpi, Jamil A.</au><au>Seidel, Veronique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antinociceptive and sedative activity of Vernonia patula and predictive interactions of its phenolic compounds with the cannabinoid type 1 receptor</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2021-02</date><risdate>2021</risdate><volume>35</volume><issue>2</issue><spage>1069</spage><epage>1079</epage><pages>1069-1079</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>When tested in the acetic acid‐induced writhing and formalin‐induced paw‐licking tests, the ethanol extract of Vernonia patula (VP) aerial parts showed significant antinociceptive activity. In neuropharmacological tests, it also significantly delayed the onset of sleep, increased the duration of sleeping time, and significantly reduced the locomotor activity and exploratory behaviour of mice. Five phenolic compounds, namely gallic acid, vanillic acid, caffeic acid, quercetin and kaempferol, were detected in VP following HPLC‐DAD analysis. The presence of these phenolic compounds in VP provides some support for the observed antinociceptive and sedative effects. A computational study was performed to predict the binding affinity of gallic acid, vanillic acid, caffeic acid, quercetin and kaempferol towards the cannabinoid type 1 (CB1) receptor. Caffeic and vanillic acid showed the highest probable ligand efficiency indices towards the CB1 target. Vanillic acid displayed the best blood–brain barrier penetration prediction score. These findings provide some evidence for the traditional use of VP to treat pain.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>33124164</pmid><doi>10.1002/ptr.6876</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-3880-5261</orcidid><orcidid>https://orcid.org/0000-0001-8159-1698</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0951-418X |
| ispartof | Phytotherapy research, 2021-02, Vol.35 (2), p.1069-1079 |
| issn | 0951-418X 1099-1573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2456418936 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Acetic acid Acids Analgesics - pharmacology Analgesics - therapeutic use Animals antinociceptive activity Blood-brain barrier Caffeic acid Cannabinoid CB1 receptors cannabinoid receptor 1 (CB1) Cannabinoids - pharmacology Cannabinoids - therapeutic use Computational neuroscience Ethanol Exploratory behavior Gallic acid High-performance liquid chromatography Hypnotics and Sedatives - pharmacology Hypnotics and Sedatives - therapeutic use Kaempferol Liquid chromatography Locomotor activity Male Mice molecular docking Pain Pain perception Phenols Phenols - pharmacology Phenols - therapeutic use Plant Extracts - chemistry Quercetin Receptors Sleep Vanillic acid Vernonia Vernonia - chemistry Vernonia patula |
| title | Antinociceptive and sedative activity of Vernonia patula and predictive interactions of its phenolic compounds with the cannabinoid type 1 receptor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T02%3A08%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antinociceptive%20and%20sedative%20activity%20of%20Vernonia%20patula%20and%20predictive%20interactions%20of%20its%20phenolic%20compounds%20with%20the%20cannabinoid%20type%201%20receptor&rft.jtitle=Phytotherapy%20research&rft.au=Siraj,%20Md%20Afjalus&rft.date=2021-02&rft.volume=35&rft.issue=2&rft.spage=1069&rft.epage=1079&rft.pages=1069-1079&rft.issn=0951-418X&rft.eissn=1099-1573&rft_id=info:doi/10.1002/ptr.6876&rft_dat=%3Cproquest_cross%3E2456418936%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2492566916&rft_id=info:pmid/33124164&rfr_iscdi=true |