Transfusion reactions associated with COVID‐19 convalescent plasma therapy for SARS‐CoV‐2
Background Convalescent plasma (CP) for treatment of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has shown preliminary signs of effectiveness in moderate to severely ill patients in reducing mortality. While studies have demonstrated a low risk of serious adverse events, the compreh...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2021-01, Vol.61 (1), p.78-93 |
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| creator | Nguyen, Freddy T. Akker, Tayler Lally, Kimberly Lam, Hansen Lenskaya, Volha Liu, Sean T. H. Bouvier, Nicole M. Aberg, Judith A. Rodriguez, Denise Krammer, Florian Strauss, Donna Shaz, Beth H. Rudon, Louella Galdon, Patricia Jhang, Jeffrey S. Arinsburg, Suzanne A. Baine, Ian |
| description | Background
Convalescent plasma (CP) for treatment of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has shown preliminary signs of effectiveness in moderate to severely ill patients in reducing mortality. While studies have demonstrated a low risk of serious adverse events, the comprehensive incidence and nature of the spectrum of transfusion reactions to CP is unknown. We retrospectively examined 427 adult inpatient CP transfusions to determine incidence and types of reactions, as well as clinical parameters and risk factors associated with transfusion reactions.
Study Design and Methods
Retrospective analysis was performed for 427 transfusions to 215 adult patients with coronavirus 2019 (COVID‐19) within the Mount Sinai Health System, through the US Food and Drug Administration emergency investigational new drug and the Mayo Clinic Expanded Access Protocol to Convalescent Plasma approval pathways. Transfusions were blindly evaluated by two reviewers and adjudicated by a third reviewer in discordant cases. Patient demographics and clinical and laboratory parameters were compared and analyzed.
Results
Fifty‐five reactions from 427 transfusions were identified (12.9% incidence), and 13 were attributed to transfusion (3.1% incidence). Reactions were classified as underlying COVID‐19 (76%), febrile nonhemolytic (10.9%), transfusion‐associated circulatory overload (9.1%), and allergic (1.8%) and hypotensive (1.8%) reactions. Statistical analysis identified increased transfusion reaction risk for ABO blood group B or Sequential Organ Failure Assessment scores of 12 to 13, and decreased risk within the age group of 80 to 89 years.
Conclusion
Our findings support the use of CP as a safe, therapeutic option from a transfusion reaction perspective, in the setting of COVID‐19. Further studies are needed to confirm the clinical significance of ABO group B, age, and predisposing disease severity in the incidence of transfusion reaction events. |
| doi_str_mv | 10.1111/trf.16177 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2456416993</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2476613077</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3537-ca81a5c0843f2761250d2eaff8236330f7fafd36769a05fc364c2b71c89f3cb83</originalsourceid><addsrcrecordid>eNp10MFKwzAcBvAgipvTgy8gAS96mMs_aZP2OKrTgTDQ6TVkWYKVrplJ69jNR_AZfRIzpx4Ec0hy-PHx8SF0DOQC4hk03l4AByF2UBdSJvo0z9Nd1CUkgT4Aox10EMIzIYTmBPZRhzGgKaRZF8mpV3WwbShdjb1RuomfgFUITpeqMXO8KpsnXEwex5cfb--QY-3qV1WZoE3d4GWlwkLh5sl4tVxj6zy-H97dR1m4x3jTQ7RnVRXM0ffbQw-jq2lx07-dXI-L4W1fs01hrTJQqSZZwiwVPLYjc2qUtRllnDFihVV2zrjguSKp1Ywnms4E6Cy3TM8y1kNn29yldy-tCY1clLFiVanauDZImqQ8AZ7nLNLTP_TZtb6O7aISnAMjQkR1vlXauxC8sXLpy4XyawlEblaXcXX5tXq0J9-J7Wxh5r_yZ-YIBluwKiuz_j9JTu9G28hPaNmNIA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2476613077</pqid></control><display><type>article</type><title>Transfusion reactions associated with COVID‐19 convalescent plasma therapy for SARS‐CoV‐2</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Nguyen, Freddy T. ; Akker, Tayler ; Lally, Kimberly ; Lam, Hansen ; Lenskaya, Volha ; Liu, Sean T. H. ; Bouvier, Nicole M. ; Aberg, Judith A. ; Rodriguez, Denise ; Krammer, Florian ; Strauss, Donna ; Shaz, Beth H. ; Rudon, Louella ; Galdon, Patricia ; Jhang, Jeffrey S. ; Arinsburg, Suzanne A. ; Baine, Ian</creator><creatorcontrib>Nguyen, Freddy T. ; Akker, Tayler ; Lally, Kimberly ; Lam, Hansen ; Lenskaya, Volha ; Liu, Sean T. H. ; Bouvier, Nicole M. ; Aberg, Judith A. ; Rodriguez, Denise ; Krammer, Florian ; Strauss, Donna ; Shaz, Beth H. ; Rudon, Louella ; Galdon, Patricia ; Jhang, Jeffrey S. ; Arinsburg, Suzanne A. ; Baine, Ian ; Mount Sinai Health System Convalescent Plasma Team ; The Mount Sinai Health System Convalescent Plasma Team</creatorcontrib><description>Background
Convalescent plasma (CP) for treatment of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has shown preliminary signs of effectiveness in moderate to severely ill patients in reducing mortality. While studies have demonstrated a low risk of serious adverse events, the comprehensive incidence and nature of the spectrum of transfusion reactions to CP is unknown. We retrospectively examined 427 adult inpatient CP transfusions to determine incidence and types of reactions, as well as clinical parameters and risk factors associated with transfusion reactions.
Study Design and Methods
Retrospective analysis was performed for 427 transfusions to 215 adult patients with coronavirus 2019 (COVID‐19) within the Mount Sinai Health System, through the US Food and Drug Administration emergency investigational new drug and the Mayo Clinic Expanded Access Protocol to Convalescent Plasma approval pathways. Transfusions were blindly evaluated by two reviewers and adjudicated by a third reviewer in discordant cases. Patient demographics and clinical and laboratory parameters were compared and analyzed.
Results
Fifty‐five reactions from 427 transfusions were identified (12.9% incidence), and 13 were attributed to transfusion (3.1% incidence). Reactions were classified as underlying COVID‐19 (76%), febrile nonhemolytic (10.9%), transfusion‐associated circulatory overload (9.1%), and allergic (1.8%) and hypotensive (1.8%) reactions. Statistical analysis identified increased transfusion reaction risk for ABO blood group B or Sequential Organ Failure Assessment scores of 12 to 13, and decreased risk within the age group of 80 to 89 years.
Conclusion
Our findings support the use of CP as a safe, therapeutic option from a transfusion reaction perspective, in the setting of COVID‐19. Further studies are needed to confirm the clinical significance of ABO group B, age, and predisposing disease severity in the incidence of transfusion reaction events.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/trf.16177</identifier><identifier>PMID: 33125158</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>ABO system ; Adverse events ; Aged ; Blood group B ; Blood groups ; Blood Transfusion ; Coronaviridae ; Coronaviruses ; COVID-19 ; COVID-19 - therapy ; Demographics ; Demography ; Female ; FFP transfusion ; Humans ; Immunization, Passive - methods ; immunology (other than RBC serology) ; Male ; Middle Aged ; Parameters ; Patients ; Retrospective Studies ; Risk analysis ; Risk factors ; SARS-CoV-2 - pathogenicity ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Statistical analysis ; Transfusion ; transfusion practices (adult) ; Transfusion Reaction ; Viral diseases</subject><ispartof>Transfusion (Philadelphia, Pa.), 2021-01, Vol.61 (1), p.78-93</ispartof><rights>2020 AABB</rights><rights>2020 AABB.</rights><rights>2021 AABB</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3537-ca81a5c0843f2761250d2eaff8236330f7fafd36769a05fc364c2b71c89f3cb83</citedby><cites>FETCH-LOGICAL-c3537-ca81a5c0843f2761250d2eaff8236330f7fafd36769a05fc364c2b71c89f3cb83</cites><orcidid>0000-0002-2270-4821 ; 0000-0002-0419-0054 ; 0000-0002-0739-9152</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftrf.16177$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftrf.16177$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33125158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nguyen, Freddy T.</creatorcontrib><creatorcontrib>Akker, Tayler</creatorcontrib><creatorcontrib>Lally, Kimberly</creatorcontrib><creatorcontrib>Lam, Hansen</creatorcontrib><creatorcontrib>Lenskaya, Volha</creatorcontrib><creatorcontrib>Liu, Sean T. H.</creatorcontrib><creatorcontrib>Bouvier, Nicole M.</creatorcontrib><creatorcontrib>Aberg, Judith A.</creatorcontrib><creatorcontrib>Rodriguez, Denise</creatorcontrib><creatorcontrib>Krammer, Florian</creatorcontrib><creatorcontrib>Strauss, Donna</creatorcontrib><creatorcontrib>Shaz, Beth H.</creatorcontrib><creatorcontrib>Rudon, Louella</creatorcontrib><creatorcontrib>Galdon, Patricia</creatorcontrib><creatorcontrib>Jhang, Jeffrey S.</creatorcontrib><creatorcontrib>Arinsburg, Suzanne A.</creatorcontrib><creatorcontrib>Baine, Ian</creatorcontrib><creatorcontrib>Mount Sinai Health System Convalescent Plasma Team</creatorcontrib><creatorcontrib>The Mount Sinai Health System Convalescent Plasma Team</creatorcontrib><title>Transfusion reactions associated with COVID‐19 convalescent plasma therapy for SARS‐CoV‐2</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>Background
Convalescent plasma (CP) for treatment of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has shown preliminary signs of effectiveness in moderate to severely ill patients in reducing mortality. While studies have demonstrated a low risk of serious adverse events, the comprehensive incidence and nature of the spectrum of transfusion reactions to CP is unknown. We retrospectively examined 427 adult inpatient CP transfusions to determine incidence and types of reactions, as well as clinical parameters and risk factors associated with transfusion reactions.
Study Design and Methods
Retrospective analysis was performed for 427 transfusions to 215 adult patients with coronavirus 2019 (COVID‐19) within the Mount Sinai Health System, through the US Food and Drug Administration emergency investigational new drug and the Mayo Clinic Expanded Access Protocol to Convalescent Plasma approval pathways. Transfusions were blindly evaluated by two reviewers and adjudicated by a third reviewer in discordant cases. Patient demographics and clinical and laboratory parameters were compared and analyzed.
Results
Fifty‐five reactions from 427 transfusions were identified (12.9% incidence), and 13 were attributed to transfusion (3.1% incidence). Reactions were classified as underlying COVID‐19 (76%), febrile nonhemolytic (10.9%), transfusion‐associated circulatory overload (9.1%), and allergic (1.8%) and hypotensive (1.8%) reactions. Statistical analysis identified increased transfusion reaction risk for ABO blood group B or Sequential Organ Failure Assessment scores of 12 to 13, and decreased risk within the age group of 80 to 89 years.
Conclusion
Our findings support the use of CP as a safe, therapeutic option from a transfusion reaction perspective, in the setting of COVID‐19. Further studies are needed to confirm the clinical significance of ABO group B, age, and predisposing disease severity in the incidence of transfusion reaction events.</description><subject>ABO system</subject><subject>Adverse events</subject><subject>Aged</subject><subject>Blood group B</subject><subject>Blood groups</subject><subject>Blood Transfusion</subject><subject>Coronaviridae</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - therapy</subject><subject>Demographics</subject><subject>Demography</subject><subject>Female</subject><subject>FFP transfusion</subject><subject>Humans</subject><subject>Immunization, Passive - methods</subject><subject>immunology (other than RBC serology)</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Parameters</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>SARS-CoV-2 - pathogenicity</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Statistical analysis</subject><subject>Transfusion</subject><subject>transfusion practices (adult)</subject><subject>Transfusion Reaction</subject><subject>Viral diseases</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MFKwzAcBvAgipvTgy8gAS96mMs_aZP2OKrTgTDQ6TVkWYKVrplJ69jNR_AZfRIzpx4Ec0hy-PHx8SF0DOQC4hk03l4AByF2UBdSJvo0z9Nd1CUkgT4Aox10EMIzIYTmBPZRhzGgKaRZF8mpV3WwbShdjb1RuomfgFUITpeqMXO8KpsnXEwex5cfb--QY-3qV1WZoE3d4GWlwkLh5sl4tVxj6zy-H97dR1m4x3jTQ7RnVRXM0ffbQw-jq2lx07-dXI-L4W1fs01hrTJQqSZZwiwVPLYjc2qUtRllnDFihVV2zrjguSKp1Ywnms4E6Cy3TM8y1kNn29yldy-tCY1clLFiVanauDZImqQ8AZ7nLNLTP_TZtb6O7aISnAMjQkR1vlXauxC8sXLpy4XyawlEblaXcXX5tXq0J9-J7Wxh5r_yZ-YIBluwKiuz_j9JTu9G28hPaNmNIA</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Nguyen, Freddy T.</creator><creator>Akker, Tayler</creator><creator>Lally, Kimberly</creator><creator>Lam, Hansen</creator><creator>Lenskaya, Volha</creator><creator>Liu, Sean T. H.</creator><creator>Bouvier, Nicole M.</creator><creator>Aberg, Judith A.</creator><creator>Rodriguez, Denise</creator><creator>Krammer, Florian</creator><creator>Strauss, Donna</creator><creator>Shaz, Beth H.</creator><creator>Rudon, Louella</creator><creator>Galdon, Patricia</creator><creator>Jhang, Jeffrey S.</creator><creator>Arinsburg, Suzanne A.</creator><creator>Baine, Ian</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2270-4821</orcidid><orcidid>https://orcid.org/0000-0002-0419-0054</orcidid><orcidid>https://orcid.org/0000-0002-0739-9152</orcidid></search><sort><creationdate>202101</creationdate><title>Transfusion reactions associated with COVID‐19 convalescent plasma therapy for SARS‐CoV‐2</title><author>Nguyen, Freddy T. ; Akker, Tayler ; Lally, Kimberly ; Lam, Hansen ; Lenskaya, Volha ; Liu, Sean T. H. ; Bouvier, Nicole M. ; Aberg, Judith A. ; Rodriguez, Denise ; Krammer, Florian ; Strauss, Donna ; Shaz, Beth H. ; Rudon, Louella ; Galdon, Patricia ; Jhang, Jeffrey S. ; Arinsburg, Suzanne A. ; Baine, Ian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-ca81a5c0843f2761250d2eaff8236330f7fafd36769a05fc364c2b71c89f3cb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>ABO system</topic><topic>Adverse events</topic><topic>Aged</topic><topic>Blood group B</topic><topic>Blood groups</topic><topic>Blood Transfusion</topic><topic>Coronaviridae</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - therapy</topic><topic>Demographics</topic><topic>Demography</topic><topic>Female</topic><topic>FFP transfusion</topic><topic>Humans</topic><topic>Immunization, Passive - methods</topic><topic>immunology (other than RBC serology)</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Parameters</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>SARS-CoV-2 - pathogenicity</topic><topic>Severe acute respiratory syndrome</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Statistical analysis</topic><topic>Transfusion</topic><topic>transfusion practices (adult)</topic><topic>Transfusion Reaction</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Freddy T.</creatorcontrib><creatorcontrib>Akker, Tayler</creatorcontrib><creatorcontrib>Lally, Kimberly</creatorcontrib><creatorcontrib>Lam, Hansen</creatorcontrib><creatorcontrib>Lenskaya, Volha</creatorcontrib><creatorcontrib>Liu, Sean T. H.</creatorcontrib><creatorcontrib>Bouvier, Nicole M.</creatorcontrib><creatorcontrib>Aberg, Judith A.</creatorcontrib><creatorcontrib>Rodriguez, Denise</creatorcontrib><creatorcontrib>Krammer, Florian</creatorcontrib><creatorcontrib>Strauss, Donna</creatorcontrib><creatorcontrib>Shaz, Beth H.</creatorcontrib><creatorcontrib>Rudon, Louella</creatorcontrib><creatorcontrib>Galdon, Patricia</creatorcontrib><creatorcontrib>Jhang, Jeffrey S.</creatorcontrib><creatorcontrib>Arinsburg, Suzanne A.</creatorcontrib><creatorcontrib>Baine, Ian</creatorcontrib><creatorcontrib>Mount Sinai Health System Convalescent Plasma Team</creatorcontrib><creatorcontrib>The Mount Sinai Health System Convalescent Plasma Team</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, Freddy T.</au><au>Akker, Tayler</au><au>Lally, Kimberly</au><au>Lam, Hansen</au><au>Lenskaya, Volha</au><au>Liu, Sean T. H.</au><au>Bouvier, Nicole M.</au><au>Aberg, Judith A.</au><au>Rodriguez, Denise</au><au>Krammer, Florian</au><au>Strauss, Donna</au><au>Shaz, Beth H.</au><au>Rudon, Louella</au><au>Galdon, Patricia</au><au>Jhang, Jeffrey S.</au><au>Arinsburg, Suzanne A.</au><au>Baine, Ian</au><aucorp>Mount Sinai Health System Convalescent Plasma Team</aucorp><aucorp>The Mount Sinai Health System Convalescent Plasma Team</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transfusion reactions associated with COVID‐19 convalescent plasma therapy for SARS‐CoV‐2</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2021-01</date><risdate>2021</risdate><volume>61</volume><issue>1</issue><spage>78</spage><epage>93</epage><pages>78-93</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><abstract>Background
Convalescent plasma (CP) for treatment of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has shown preliminary signs of effectiveness in moderate to severely ill patients in reducing mortality. While studies have demonstrated a low risk of serious adverse events, the comprehensive incidence and nature of the spectrum of transfusion reactions to CP is unknown. We retrospectively examined 427 adult inpatient CP transfusions to determine incidence and types of reactions, as well as clinical parameters and risk factors associated with transfusion reactions.
Study Design and Methods
Retrospective analysis was performed for 427 transfusions to 215 adult patients with coronavirus 2019 (COVID‐19) within the Mount Sinai Health System, through the US Food and Drug Administration emergency investigational new drug and the Mayo Clinic Expanded Access Protocol to Convalescent Plasma approval pathways. Transfusions were blindly evaluated by two reviewers and adjudicated by a third reviewer in discordant cases. Patient demographics and clinical and laboratory parameters were compared and analyzed.
Results
Fifty‐five reactions from 427 transfusions were identified (12.9% incidence), and 13 were attributed to transfusion (3.1% incidence). Reactions were classified as underlying COVID‐19 (76%), febrile nonhemolytic (10.9%), transfusion‐associated circulatory overload (9.1%), and allergic (1.8%) and hypotensive (1.8%) reactions. Statistical analysis identified increased transfusion reaction risk for ABO blood group B or Sequential Organ Failure Assessment scores of 12 to 13, and decreased risk within the age group of 80 to 89 years.
Conclusion
Our findings support the use of CP as a safe, therapeutic option from a transfusion reaction perspective, in the setting of COVID‐19. Further studies are needed to confirm the clinical significance of ABO group B, age, and predisposing disease severity in the incidence of transfusion reaction events.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33125158</pmid><doi>10.1111/trf.16177</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-2270-4821</orcidid><orcidid>https://orcid.org/0000-0002-0419-0054</orcidid><orcidid>https://orcid.org/0000-0002-0739-9152</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | ABO system Adverse events Aged Blood group B Blood groups Blood Transfusion Coronaviridae Coronaviruses COVID-19 COVID-19 - therapy Demographics Demography Female FFP transfusion Humans Immunization, Passive - methods immunology (other than RBC serology) Male Middle Aged Parameters Patients Retrospective Studies Risk analysis Risk factors SARS-CoV-2 - pathogenicity Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Statistical analysis Transfusion transfusion practices (adult) Transfusion Reaction Viral diseases |
| title | Transfusion reactions associated with COVID‐19 convalescent plasma therapy for SARS‐CoV‐2 |
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