Serum Uric Acid may be Associated with Left Ventricular Diastolic Dysfunction in Military Individuals

Serum Uric Acid may be Associated with Left Ventricular Diastolic Dysfunction in Military Individuals

We investigated the correlation and association between serum uric acid (SUA) and left ventricular diastolic dysfunction (LVDD) criteria in military individuals. We prospectively enrolled military individuals who visited our hospital for evaluation of electrocardiographic abnormalities detected at a...

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Veröffentlicht in:Military medicine 2021-01, Vol.186 (1-2), p.e104-e111
Hauptverfasser: Tu, Chung-Ming, Tseng, Guo-Shiang, Liu, Cheng-Wei
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Tseng, Guo-Shiang
Liu, Cheng-Wei
description We investigated the correlation and association between serum uric acid (SUA) and left ventricular diastolic dysfunction (LVDD) criteria in military individuals. We prospectively enrolled military individuals who visited our hospital for evaluation of electrocardiographic abnormalities detected at an annual health exam between January 1, 2018 and December 31, 2019. Hyperuricemia was defined as an SUA level ≥7 mg/dL in men and ≥6 mg/dL in women. The definitions of LVDD criteria and LV hypertrophy were according to contemporary echocardiographic guidelines. The study included 268 individuals (89% male), with a mean age of 32.9 ± 7.6 years and SUA of 6.1 ± 1.3 mg/dL. The hyperuricemic (n = 74) and normouricemic (n = 194) groups had no significant differences in lifestyle choices and baseline characteristics. Serum uric acid correlated weakly with heart size parameters (r = 0.354, P 
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We prospectively enrolled military individuals who visited our hospital for evaluation of electrocardiographic abnormalities detected at an annual health exam between January 1, 2018 and December 31, 2019. Hyperuricemia was defined as an SUA level ≥7 mg/dL in men and ≥6 mg/dL in women. The definitions of LVDD criteria and LV hypertrophy were according to contemporary echocardiographic guidelines. The study included 268 individuals (89% male), with a mean age of 32.9 ± 7.6 years and SUA of 6.1 ± 1.3 mg/dL. The hyperuricemic (n = 74) and normouricemic (n = 194) groups had no significant differences in lifestyle choices and baseline characteristics. Serum uric acid correlated weakly with heart size parameters (r = 0.354, P &lt; .001 for left atrial diameter and r = 0.146, P = .017 for left ventricular mass index (LVMI) and average E/e' &gt;14 (r = 0.204, P = .001). The hyperuricemic group had higher LVMI (87.6 g/m2 vs. 81.8 g/m2, P = .022), septal e' velocity &lt;7 cm/s (14.9% vs. 5.2%, P = .019), lateral e' velocity &lt;10 cm/s (27.0% vs. 11.3%, P = .003), and average E/e' &gt;14 (4.1% vs. 0%, P = .020) values than the normouricemic group. In multivariate logistic regression analyses, SUA was significantly associated with septal e' velocity &lt;7 cm/s (adjusted HR: 2.398; 95% CI, 1.427-4.030; P = .001). Elevated SUA was significantly associated with the presence of LVDD criteria, namely, septal e' velocity &lt;7, in military individuals. Maintaining SUA levels within normal limits may prevent the development of LVDD.</description><identifier>ISSN: 0026-4075</identifier><identifier>EISSN: 1930-613X</identifier><identifier>DOI: 10.1093/milmed/usaa413</identifier><identifier>PMID: 33128558</identifier><language>eng</language><publisher>England</publisher><ispartof>Military medicine, 2021-01, Vol.186 (1-2), p.e104-e111</ispartof><rights>The Association of Military Surgeons of the United States 2021. All rights reserved. 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We prospectively enrolled military individuals who visited our hospital for evaluation of electrocardiographic abnormalities detected at an annual health exam between January 1, 2018 and December 31, 2019. Hyperuricemia was defined as an SUA level ≥7 mg/dL in men and ≥6 mg/dL in women. The definitions of LVDD criteria and LV hypertrophy were according to contemporary echocardiographic guidelines. The study included 268 individuals (89% male), with a mean age of 32.9 ± 7.6 years and SUA of 6.1 ± 1.3 mg/dL. The hyperuricemic (n = 74) and normouricemic (n = 194) groups had no significant differences in lifestyle choices and baseline characteristics. Serum uric acid correlated weakly with heart size parameters (r = 0.354, P &lt; .001 for left atrial diameter and r = 0.146, P = .017 for left ventricular mass index (LVMI) and average E/e' &gt;14 (r = 0.204, P = .001). The hyperuricemic group had higher LVMI (87.6 g/m2 vs. 81.8 g/m2, P = .022), septal e' velocity &lt;7 cm/s (14.9% vs. 5.2%, P = .019), lateral e' velocity &lt;10 cm/s (27.0% vs. 11.3%, P = .003), and average E/e' &gt;14 (4.1% vs. 0%, P = .020) values than the normouricemic group. In multivariate logistic regression analyses, SUA was significantly associated with septal e' velocity &lt;7 cm/s (adjusted HR: 2.398; 95% CI, 1.427-4.030; P = .001). Elevated SUA was significantly associated with the presence of LVDD criteria, namely, septal e' velocity &lt;7, in military individuals. 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We prospectively enrolled military individuals who visited our hospital for evaluation of electrocardiographic abnormalities detected at an annual health exam between January 1, 2018 and December 31, 2019. Hyperuricemia was defined as an SUA level ≥7 mg/dL in men and ≥6 mg/dL in women. The definitions of LVDD criteria and LV hypertrophy were according to contemporary echocardiographic guidelines. The study included 268 individuals (89% male), with a mean age of 32.9 ± 7.6 years and SUA of 6.1 ± 1.3 mg/dL. The hyperuricemic (n = 74) and normouricemic (n = 194) groups had no significant differences in lifestyle choices and baseline characteristics. Serum uric acid correlated weakly with heart size parameters (r = 0.354, P &lt; .001 for left atrial diameter and r = 0.146, P = .017 for left ventricular mass index (LVMI) and average E/e' &gt;14 (r = 0.204, P = .001). The hyperuricemic group had higher LVMI (87.6 g/m2 vs. 81.8 g/m2, P = .022), septal e' velocity &lt;7 cm/s (14.9% vs. 5.2%, P = .019), lateral e' velocity &lt;10 cm/s (27.0% vs. 11.3%, P = .003), and average E/e' &gt;14 (4.1% vs. 0%, P = .020) values than the normouricemic group. In multivariate logistic regression analyses, SUA was significantly associated with septal e' velocity &lt;7 cm/s (adjusted HR: 2.398; 95% CI, 1.427-4.030; P = .001). Elevated SUA was significantly associated with the presence of LVDD criteria, namely, septal e' velocity &lt;7, in military individuals. Maintaining SUA levels within normal limits may prevent the development of LVDD.</abstract><cop>England</cop><pmid>33128558</pmid><doi>10.1093/milmed/usaa413</doi><oa>free_for_read</oa></addata></record>
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title Serum Uric Acid may be Associated with Left Ventricular Diastolic Dysfunction in Military Individuals
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