Histone lysine demethylases and their functions in cancer

Histone lysine demethylases (KDMs) are enzymes that remove the methylation marks on lysines in nucleosomes' histone tails. These changes in methylation marks regulate gene transcription during both development and malignant transformation. Depending on which lysine residue is targeted, the effe...

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Veröffentlicht in:	International journal of cancer 2021-05, Vol.148 (10), p.2375-2388
Hauptverfasser:	Sterling, Jayden, Menezes, Sharleen V., Abbassi, Ramzi H., Munoz, Lenka
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer DNA methylation drug resistance Drug tolerance Epigenetics histone lysine demethylase histone methylation Histones Lysine Medical research Nonhistone proteins Nucleosomes Stem cells Tumors
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