Negative Food Effect of Danirixin: Use of PBPK Modelling to Explore the Effect of Formulation and Meal Type on Clinical PK

Purpose To use physiologically-based pharmacokinetic (PBPK) modelling to explore the food effect of different DNX hydrobromide (HBr) hemihydrate salt tablet formulations using biorelevant dissolution. Methods Compendial dissolution using a paddle method and TIM-1 biorelevant dissolution were perform...

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Veröffentlicht in:	Pharmaceutical research 2020-12, Vol.37 (12), p.233-233, Article 233
Hauptverfasser:	Lloyd, Richard S., Hingle, Martin I., Bloomer, Jackie C., Charles, Stephen J., Butler, James M., Paul, Alan, Zhu, Xiaofeng, Miller, Bruce, D’Amico, Donald, Donald, Alison, Tal-Singer, Ruth, Ambery, Claire
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Dissolution Food Food selection Medical Law Pharmacokinetics Pharmacology/Toxicology Pharmacy Proton pump inhibitors Research Paper
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