Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors

Carbonic anhydrase (CA, EC 4.2.1.1) is an enzyme and a very omnipresent zinc metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide and bicarbonate; a reaction which plays a crucial role in many physiological and pathological processes. Carbonic anhydrase is present...

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Veröffentlicht in:	European journal of medicinal chemistry 2021-01, Vol.209, p.112923-112923, Article 112923
Hauptverfasser:	Kumar, Shubham, Rulhania, Sandeep, Jaswal, Shalini, Monga, Vikramdeep
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetazolamide - chemistry Acetazolamide - pharmacology Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antioxidants - chemistry Antioxidants - pharmacology Benzenesulfonamide Benzenesulfonamides Carbonic anhydrase Carbonic anhydrase inhibitors Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrases - metabolism Cytotoxicity, Docking Enzyme inhibition Humans Indoles - chemistry Isatin - chemistry Molecular Docking Simulation Organoselenium Compounds - chemistry Oxadiazoles - chemistry Protein Binding Protein Isoforms - chemistry Pyrimidines - chemistry Structure-Activity Relationship Sulfonamides - chemistry Sulfonamides - pharmacology Thiazines - chemistry Thiazines - pharmacology Thiophenes - chemistry Thiophenes - pharmacology Urea - analogs & derivatives Urea - chemistry
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