ERCC3, a new ovarian cancer susceptibility gene?

Hereditary breast and ovarian cancer syndrome (HBOC) is an inherited disorder with an increased risk of breast cancer (BC) and ovarian cancers (OC). Mutations in BRCA1-BRCA2 explains less than a half of cases. In the last decade several genes with different penetrance have been associated with an in...

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Veröffentlicht in:	European journal of cancer (1990) 2020-12, Vol.141, p.1-8
Hauptverfasser:	Stradella, Agostina, del Valle, Jesús, Rofes, Paula, Vargas-Parra, Gardenia, Salinas, Mónica, González, Sara, Montes, Eva, López-Doriga, Adriana, Gómez, Carolina, de Cid, Rafael, Darder, Esther, Teulé, Alex, Solanes, Ares, Munté, Elisabet, Capellà, Gabriel, Pineda, Marta, Feliubadaló, Lidia, Brunet, Joan, Lázaro, Conxi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult BRCA1 protein BRCA2 protein Breast cancer Confidence intervals DNA Helicases - genetics DNA-Binding Proteins - genetics ERCC3 Female Genetic disorders Genetic Predisposition to Disease - genetics Genetic screening HBOC Health risks Hereditary Breast and Ovarian Cancer Hereditary Breast and Ovarian Cancer Syndrome - genetics Humans Middle Aged Moderate cancer risk Mutation Ovarian cancer p53 Protein Pedigree Population control Risk Statistical analysis
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