Quantification of antibody avidities and accurate detection of SARS-CoV-2 antibodies in serum and saliva on plasmonic substrates

Accurate assays for the detection of antibodies to SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) are essential for the control of the COVID-19 (coronavirus disease 2019) pandemic. Here, we report antibody and antibody-avidity assays, relying on near-infrared-fluorescence amplification...

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Veröffentlicht in:	Nature biomedical engineering 2020-12, Vol.4 (12), p.1188-1196
Hauptverfasser:	Liu, Tiancheng, Hsiung, Jessica, Zhao, Su, Kost, Jessica, Sreedhar, Deepika, Hanson, Carl V., Olson, Kjerstie, Keare, Douglas, Chang, Shin Ting, Bliden, Kevin P., Gurbel, Paul A., Tantry, Udaya S., Roche, John, Press, Cynthia, Boggs, John, Rodriguez-Soto, Jorge P., Montoya, Jose G., Tang, Meijie, Dai, Hongjie
Format:	Artikel
Sprache:	eng
Schlagworte:	38/79 42/34 631/61/32 692/699/255/2514 82/1 96/47 Aged Amplification Antibodies Antibodies, Viral - blood Antibodies, Viral - immunology Antibody Affinity - immunology Antigens Antigens, Viral - immunology Assaying Avidity Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Coronaviridae Coronaviruses COVID-19 COVID-19 - blood COVID-19 - immunology COVID-19 Serological Testing - methods Female Fluorescence Gold Humans I.R. radiation Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin M Immunoglobulin M - blood Immunoglobulin M - immunology Immunoglobulins Nanostructure Pandemics Pandemics - prevention & control Plasmonics Saliva Saliva - immunology SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Spike protein Substrates Viral diseases Viruses
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