The phytoestrogen glabrene prevents osteoporosis in ovariectomized rats through upregulation of the canonical Wnt/β‐catenin signaling pathway

This study systematically investigated the effects of phytoestrogen glabrene on postmenopausal osteoporosis in an ovariectomy (OVX) rat model. Glabrene administration (25, 50, and 100 mg/kg) for 13 weeks can significantly slow down the body weight gain and slightly increase the uterus weight of OVX...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2021-02, Vol.35 (2), p.e22653-n/a
Hauptverfasser:	Liu, Jun, Deng, Xinchang, Liang, Xiao, Li, Longying
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative medicine Biomechanics Biomedical materials Body weight Body weight gain Bone mineral density bone turnover Catenin Cbfa-1 protein Cholesterol Compression Creatinine Femur glabrene Mechanical loading Osteoporosis Osteoprotegerin Ovariectomy phytoestrogen Post-menopause postmenopausal osteoporosis Protein expression Proteins Rodents Signal transduction Signaling Tibia TRAP protein Triglycerides Uterus Vertebrae Wnt protein Wnt/β‐catenin signaling pathway
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