The phytoestrogen glabrene prevents osteoporosis in ovariectomized rats through upregulation of the canonical Wnt/β‐catenin signaling pathway
This study systematically investigated the effects of phytoestrogen glabrene on postmenopausal osteoporosis in an ovariectomy (OVX) rat model. Glabrene administration (25, 50, and 100 mg/kg) for 13 weeks can significantly slow down the body weight gain and slightly increase the uterus weight of OVX...
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| Veröffentlicht in: | Journal of biochemical and molecular toxicology 2021-02, Vol.35 (2), p.e22653-n/a |
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| creator | Liu, Jun Deng, Xinchang Liang, Xiao Li, Longying |
| description | This study systematically investigated the effects of phytoestrogen glabrene on postmenopausal osteoporosis in an ovariectomy (OVX) rat model. Glabrene administration (25, 50, and 100 mg/kg) for 13 weeks can significantly slow down the body weight gain and slightly increase the uterus weight of OVX rats. The increased levels of U‐Ca, U‐P levels, urine DPD/creatinine, serum ALP, OCN, triglycerides, and total cholesterol induced by OVX were dramatically inhibited in rats, whereas no difference occurred for S‐Ca and S‐P in all groups. Furthermore, glabrene can enhance bone mineral density of the right femur, fourth‐lumbar vertebra and tibia and improve biomechanical parameters, such as femoral neck loading force, three‐point bending of the tibia, and vertebral compression in OVX rats. Moreover, glabrene greatly suppressed the expression of TRAP protein but increased OPG and BGP protein expression in tibia tissue of OVX rats. In addition, OVX‐induced reduction of Lrp‐5, β‐catenin, Runx2, and Osx protein expression was all restored by glabrene treatment. The present study indicated that glabrene might be a potential alternative medicine for the prevention and treatment of postmenopausal osteoporosis via activation of the Wnt/β‐catenin signaling pathway. |
| doi_str_mv | 10.1002/jbt.22653 |
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Glabrene administration (25, 50, and 100 mg/kg) for 13 weeks can significantly slow down the body weight gain and slightly increase the uterus weight of OVX rats. The increased levels of U‐Ca, U‐P levels, urine DPD/creatinine, serum ALP, OCN, triglycerides, and total cholesterol induced by OVX were dramatically inhibited in rats, whereas no difference occurred for S‐Ca and S‐P in all groups. Furthermore, glabrene can enhance bone mineral density of the right femur, fourth‐lumbar vertebra and tibia and improve biomechanical parameters, such as femoral neck loading force, three‐point bending of the tibia, and vertebral compression in OVX rats. Moreover, glabrene greatly suppressed the expression of TRAP protein but increased OPG and BGP protein expression in tibia tissue of OVX rats. In addition, OVX‐induced reduction of Lrp‐5, β‐catenin, Runx2, and Osx protein expression was all restored by glabrene treatment. The present study indicated that glabrene might be a potential alternative medicine for the prevention and treatment of postmenopausal osteoporosis via activation of the Wnt/β‐catenin signaling pathway.</description><identifier>ISSN: 1095-6670</identifier><identifier>EISSN: 1099-0461</identifier><identifier>DOI: 10.1002/jbt.22653</identifier><identifier>PMID: 33113278</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Alternative medicine ; Biomechanics ; Biomedical materials ; Body weight ; Body weight gain ; Bone mineral density ; bone turnover ; Catenin ; Cbfa-1 protein ; Cholesterol ; Compression ; Creatinine ; Femur ; glabrene ; Mechanical loading ; Osteoporosis ; Osteoprotegerin ; Ovariectomy ; phytoestrogen ; Post-menopause ; postmenopausal osteoporosis ; Protein expression ; Proteins ; Rodents ; Signal transduction ; Signaling ; Tibia ; TRAP protein ; Triglycerides ; Uterus ; Vertebrae ; Wnt protein ; Wnt/β‐catenin signaling pathway</subject><ispartof>Journal of biochemical and molecular toxicology, 2021-02, Vol.35 (2), p.e22653-n/a</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><rights>2021 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-c2c1d6affaf90c8f1bb97c84fe8621e2de455367eb40a7d63f3b6571530b03e43</citedby><cites>FETCH-LOGICAL-c3533-c2c1d6affaf90c8f1bb97c84fe8621e2de455367eb40a7d63f3b6571530b03e43</cites><orcidid>0000-0002-6932-7920</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbt.22653$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbt.22653$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33113278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Jun</creatorcontrib><creatorcontrib>Deng, Xinchang</creatorcontrib><creatorcontrib>Liang, Xiao</creatorcontrib><creatorcontrib>Li, Longying</creatorcontrib><title>The phytoestrogen glabrene prevents osteoporosis in ovariectomized rats through upregulation of the canonical Wnt/β‐catenin signaling pathway</title><title>Journal of biochemical and molecular toxicology</title><addtitle>J Biochem Mol Toxicol</addtitle><description>This study systematically investigated the effects of phytoestrogen glabrene on postmenopausal osteoporosis in an ovariectomy (OVX) rat model. Glabrene administration (25, 50, and 100 mg/kg) for 13 weeks can significantly slow down the body weight gain and slightly increase the uterus weight of OVX rats. The increased levels of U‐Ca, U‐P levels, urine DPD/creatinine, serum ALP, OCN, triglycerides, and total cholesterol induced by OVX were dramatically inhibited in rats, whereas no difference occurred for S‐Ca and S‐P in all groups. Furthermore, glabrene can enhance bone mineral density of the right femur, fourth‐lumbar vertebra and tibia and improve biomechanical parameters, such as femoral neck loading force, three‐point bending of the tibia, and vertebral compression in OVX rats. Moreover, glabrene greatly suppressed the expression of TRAP protein but increased OPG and BGP protein expression in tibia tissue of OVX rats. In addition, OVX‐induced reduction of Lrp‐5, β‐catenin, Runx2, and Osx protein expression was all restored by glabrene treatment. The present study indicated that glabrene might be a potential alternative medicine for the prevention and treatment of postmenopausal osteoporosis via activation of the Wnt/β‐catenin signaling pathway.</description><subject>Alternative medicine</subject><subject>Biomechanics</subject><subject>Biomedical materials</subject><subject>Body weight</subject><subject>Body weight gain</subject><subject>Bone mineral density</subject><subject>bone turnover</subject><subject>Catenin</subject><subject>Cbfa-1 protein</subject><subject>Cholesterol</subject><subject>Compression</subject><subject>Creatinine</subject><subject>Femur</subject><subject>glabrene</subject><subject>Mechanical loading</subject><subject>Osteoporosis</subject><subject>Osteoprotegerin</subject><subject>Ovariectomy</subject><subject>phytoestrogen</subject><subject>Post-menopause</subject><subject>postmenopausal osteoporosis</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Signal transduction</subject><subject>Signaling</subject><subject>Tibia</subject><subject>TRAP protein</subject><subject>Triglycerides</subject><subject>Uterus</subject><subject>Vertebrae</subject><subject>Wnt protein</subject><subject>Wnt/β‐catenin signaling pathway</subject><issn>1095-6670</issn><issn>1099-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kc9u1DAQhyNERUvhwAsgS1zgkK7_xHZyhAooqBKXRRwjxxknXmXtYDutlhOP0GfhQXgInqTebssBidNYo28-zfhXFC8IPiMY09WmS2eUCs4eFScEN02JK0Ee3715KYTEx8XTGDcYY95I_qQ4ZowQRmV9UtysR0DzuEseYgp-AIeGSXUBXG4HuAKXIvIxgZ998NFGZB3yVypY0Mlv7Q_oUVCZSWPwyzCiJU8Ny6SS9Rk0uQ9IK-ed1WpC31xa_f715-eNVglcVkU7ODVZN6BZpfFa7Z4VR0ZNEZ7f19Pi64f36_OL8vLLx0_nby9LzThjpaaa9EIZo0yDdW1I1zVS15WBWlACtIeKcyYkdBVWshfMsE5wSTjDHWZQsdPi9cE7B_99yce3Wxs1TJNy4JfY0jxfV1UleUZf_YNu_BLy2nuqlriRFO-Fbw6Uzv8UA5h2Dnarwq4luN3H1OaY2ruYMvvy3rh0W-j_kg-5ZGB1AK7tBLv_m9rP79YH5S03hKGH</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Liu, Jun</creator><creator>Deng, Xinchang</creator><creator>Liang, Xiao</creator><creator>Li, Longying</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6932-7920</orcidid></search><sort><creationdate>202102</creationdate><title>The phytoestrogen glabrene prevents osteoporosis in ovariectomized rats through upregulation of the canonical Wnt/β‐catenin signaling pathway</title><author>Liu, Jun ; Deng, Xinchang ; Liang, Xiao ; Li, Longying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-c2c1d6affaf90c8f1bb97c84fe8621e2de455367eb40a7d63f3b6571530b03e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alternative medicine</topic><topic>Biomechanics</topic><topic>Biomedical materials</topic><topic>Body weight</topic><topic>Body weight gain</topic><topic>Bone mineral density</topic><topic>bone turnover</topic><topic>Catenin</topic><topic>Cbfa-1 protein</topic><topic>Cholesterol</topic><topic>Compression</topic><topic>Creatinine</topic><topic>Femur</topic><topic>glabrene</topic><topic>Mechanical loading</topic><topic>Osteoporosis</topic><topic>Osteoprotegerin</topic><topic>Ovariectomy</topic><topic>phytoestrogen</topic><topic>Post-menopause</topic><topic>postmenopausal osteoporosis</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Rodents</topic><topic>Signal transduction</topic><topic>Signaling</topic><topic>Tibia</topic><topic>TRAP protein</topic><topic>Triglycerides</topic><topic>Uterus</topic><topic>Vertebrae</topic><topic>Wnt protein</topic><topic>Wnt/β‐catenin signaling pathway</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Jun</creatorcontrib><creatorcontrib>Deng, Xinchang</creatorcontrib><creatorcontrib>Liang, Xiao</creatorcontrib><creatorcontrib>Li, Longying</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biochemical and molecular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Jun</au><au>Deng, Xinchang</au><au>Liang, Xiao</au><au>Li, Longying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The phytoestrogen glabrene prevents osteoporosis in ovariectomized rats through upregulation of the canonical Wnt/β‐catenin signaling pathway</atitle><jtitle>Journal of biochemical and molecular toxicology</jtitle><addtitle>J Biochem Mol Toxicol</addtitle><date>2021-02</date><risdate>2021</risdate><volume>35</volume><issue>2</issue><spage>e22653</spage><epage>n/a</epage><pages>e22653-n/a</pages><issn>1095-6670</issn><eissn>1099-0461</eissn><abstract>This study systematically investigated the effects of phytoestrogen glabrene on postmenopausal osteoporosis in an ovariectomy (OVX) rat model. Glabrene administration (25, 50, and 100 mg/kg) for 13 weeks can significantly slow down the body weight gain and slightly increase the uterus weight of OVX rats. The increased levels of U‐Ca, U‐P levels, urine DPD/creatinine, serum ALP, OCN, triglycerides, and total cholesterol induced by OVX were dramatically inhibited in rats, whereas no difference occurred for S‐Ca and S‐P in all groups. Furthermore, glabrene can enhance bone mineral density of the right femur, fourth‐lumbar vertebra and tibia and improve biomechanical parameters, such as femoral neck loading force, three‐point bending of the tibia, and vertebral compression in OVX rats. Moreover, glabrene greatly suppressed the expression of TRAP protein but increased OPG and BGP protein expression in tibia tissue of OVX rats. In addition, OVX‐induced reduction of Lrp‐5, β‐catenin, Runx2, and Osx protein expression was all restored by glabrene treatment. The present study indicated that glabrene might be a potential alternative medicine for the prevention and treatment of postmenopausal osteoporosis via activation of the Wnt/β‐catenin signaling pathway.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33113278</pmid><doi>10.1002/jbt.22653</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-6932-7920</orcidid></addata></record> |
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| subjects | Alternative medicine Biomechanics Biomedical materials Body weight Body weight gain Bone mineral density bone turnover Catenin Cbfa-1 protein Cholesterol Compression Creatinine Femur glabrene Mechanical loading Osteoporosis Osteoprotegerin Ovariectomy phytoestrogen Post-menopause postmenopausal osteoporosis Protein expression Proteins Rodents Signal transduction Signaling Tibia TRAP protein Triglycerides Uterus Vertebrae Wnt protein Wnt/β‐catenin signaling pathway |
| title | The phytoestrogen glabrene prevents osteoporosis in ovariectomized rats through upregulation of the canonical Wnt/β‐catenin signaling pathway |
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