Lysophosphatidic acid induces thrombospondin‐1 production in primary cultured rat cortical astrocytes

Lysophosphatidic acid (LPA), a brain membrane‐derived lipid mediator, plays important roles including neural development, function, and behavior. In the present study, the effects of LPA on astrocyte‐derived synaptogenesis factor thrombospondins (TSPs) production were examined by real‐time PCR and w...

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Veröffentlicht in:	Journal of neurochemistry 2021-08, Vol.158 (4), p.849-864
Hauptverfasser:	Hisaoka‐Nakashima, Kazue, Yokoe, Toshiki, Watanabe, Shintaro, Nakamura, Yoki, Kajitani, Naoto, Okada‐Tsuchioka, Mami, Takebayashi, Minoru, Nakata, Yoshihiro, Morioka, Norimitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Affective disorders Antidepressants Astrocytes Disorders Enzyme inhibitors Extracellular signal-regulated kinase Gene expression JNK protein Kinases Lipids Lysophosphatidic acid MAP kinase Pathogenesis Pertussis Pertussis toxin Phosphorylation Protein expression Protein kinase Proteins Receptors Signaling Synaptogenesis Thrombospondin thrombospondin‐1 Toxins Western blotting
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