Cell‐permeable CaaX‐peptides affect K‐Ras downstream signaling and promote cell death in cancer cells

Cell‐permeable peptides bearing a C‐terminal CaaX motif based on Ras sequences are introduced. We highlight intracellular accumulation of those peptides, which is controlled by the presence of their CaaX motif, and their specific interaction with intracellular prenyltransferases. As proof of concept...

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