Recurrent HNSCC Harbor an Immunosuppressive Tumor Immune Microenvironment Suggesting Successful Tumor Immune Evasion

Recurrent tumors (RT) of head and neck squamous cell carcinoma (HNSCC) occur in up to 60%, with poor therapeutic response and detrimental prognosis. We hypothesized that HNSCC RTs successfully evade antitumor immune response and aimed to reveal tumor immune microenvironment (TIME) changes of primary...

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Veröffentlicht in:	Clinical cancer research 2021-01, Vol.27 (2), p.632-644
Hauptverfasser:	Watermann, Christian, Pasternack, Helen, Idel, Christian, Ribbat-Idel, Julika, Brägelmann, Johannes, Kuppler, Patrick, Offermann, Anne, Jonigk, Danny, Kühnel, Mark Philipp, Schröck, Andreas, Dreyer, Eva, Rosero, Christian, Nathansen, Jacqueline, Dubrovska, Anna, Tharun, Lars, Kirfel, Jutta, Wollenberg, Barbara, Perner, Sven, Krupar, Rosemarie
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - therapy CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor Cell Survival - genetics Cell Survival - immunology Cohort Studies Female Forkhead Transcription Factors - immunology Forkhead Transcription Factors - metabolism Gene Expression Regulation, Neoplastic - immunology Head and Neck Neoplasms - immunology Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - therapy Humans Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Male Middle Aged Neoplasm Recurrence, Local Prognosis Tumor Escape - genetics Tumor Escape - immunology Tumor Microenvironment - genetics Tumor Microenvironment - immunology
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