Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy

Targeted cancer therapies represent a milestone towards personalized treatment as they function via inhibition of cancer-specific alterations. Polymerase θ (POLQ), an error-prone translesion polymerase, also involved in DNA double-strand break (DSB) repair, is often upregulated in cancer. POLQ is sy...

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Veröffentlicht in:	Trends in Cancer 2021-02, Vol.7 (2), p.98-111
Hauptverfasser:	Schrempf, Anna, Slyskova, Jana, Loizou, Joanna I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use BRCA1 Protein - genetics BRCA1 Protein - metabolism BRCA2 Protein - genetics BRCA2 Protein - metabolism Cell Line, Tumor Disease Models, Animal DNA Breaks, Double-Stranded DNA Polymerase theta DNA Repair - drug effects DNA-Directed DNA Polymerase - metabolism Drug Development - trends Homologous Recombination - drug effects Humans Mice Molecular Targeted Therapy - methods Neoplasms - drug therapy Neoplasms - genetics Neoplasms - mortality Nucleic Acid Synthesis Inhibitors - pharmacology Nucleic Acid Synthesis Inhibitors - therapeutic use Prognosis Synthetic Lethal Mutations - drug effects
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