Noscapine alleviates cerebral damage in ischemia-reperfusion injury in rats

With high unmet medical needs, stroke remains an intensely focused research area. Although noscapine is a neuroprotective agent, its mechanism of action in ischemic-reperfusion (I-R) injury is yet to be ascertained. We investigated the effect of noscapine on the molecular mechanisms of cell damage u...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2021-04, Vol.394 (4), p.669-683
Hauptverfasser:	Kawadkar, Manisha, Mandloi, Avinash S., Saxena, Vidhu, Tamadaddi, Chetana, Sahi, Chandan, Dhote, Vipin V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Biomedical and Life Sciences Biomedicine Brain - drug effects Brain - metabolism Brain - pathology Cell viability Cerebral blood flow Edema Gait - drug effects Glutathione Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - metabolism Infarction, Middle Cerebral Artery - pathology Inflammation Ischemia Lipid peroxidation Male Molecular modelling Muscle Strength - drug effects Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurosciences Noscapine - pharmacology Noscapine - therapeutic use Original Article Oxidative stress Oxidative Stress - drug effects Peroxidase Peroxidase - metabolism Pharmacology/Toxicology Psychomotor Performance - drug effects Rats Rats, Wistar Reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - pathology Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - growth & development Superoxide dismutase Yeast
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