Beneficial effects of vitamin D on anxiety and depression-like behaviors induced by unpredictable chronic mild stress by suppression of brain oxidative stress and neuroinflammation in rats
The objective of this study was to investigate the protective effects of vitamin D (Vit D) on anxiety and depression-like behaviors induced by unpredictable chronic mild stress and brain tissue oxidative damage criteria and neuroinflammation in rats. The rats were treated as follows: (1) control, (2...
Gespeichert in:
| Veröffentlicht in: | Naunyn-Schmiedeberg's archives of pharmacology 2021-04, Vol.394 (4), p.655-667 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 667 |
|---|---|
| container_issue | 4 |
| container_start_page | 655 |
| container_title | Naunyn-Schmiedeberg's archives of pharmacology |
| container_volume | 394 |
| creator | Bakhtiari-Dovvombaygi, Hossein Izadi, Saeed Zare Moghaddam, Mostafa Hashemzehi, Milad Hosseini, Mahmoud Azhdari-Zarmehri, Hassan Dinpanah, Hossein Beheshti, Farimah |
| description | The objective of this study was to investigate the protective effects of vitamin D (Vit D) on anxiety and depression-like behaviors induced by unpredictable chronic mild stress and brain tissue oxidative damage criteria and neuroinflammation in rats. The rats were treated as follows: (1) control, (2) UCMS, (3–5) Vit D 100, 1000, and 10,000 iu + UCMS. Rats were subjected to UCMS for a total of 4 weeks. During week 4, they received seven training trials. The brains were then collected to examine inflammation and oxidative stress criteria. Pretreatment with Vit D enhanced performances of the rats in the elevated plus maze (EPM) and open field (OF) and forced swimming test (FST). UCMS also increased MDA and interleukin-6 (IL-6) levels while decreased CAT, SOD, and thiol. Vit D reversed the effects of UCMS. The results of the current research revealed that Vit D improved UCMS-induced anxiety and depression via decreasing brain oxidative stress and inhibiting neuroinflammation. |
| doi_str_mv | 10.1007/s00210-020-02002-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2454656399</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2454656399</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-aa3d3db8af648dfebcd77d66c121f226d6ae7250eba94ee031e8a5afc4acfaa3</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhS0EokPbF2CBLLFhE-qfxEmW0PInVWLTvXVjX1OXxB7sZNR5Nx4Op9MBiUUX1pV8v3POlQ4hrzl7zxlrLzJjgrOKiYfHRMWekQ2vpah4z8Vzsil_XcVF352QVznfMcYUb5qX5ERKzlTP-w35_REDOm88jBSdQzNnGh3d-RkmH-gVjYFCuPc478u01OI2Yc4-hmr0P5EOeAs7H1OmPtjFoKXDni6hQNabGYYRqblNMXhDJz9amudVvkJ52R6t1sQhQcmL997C7Hd4BNfMgEuKPrgRpqksC1_IBHM-Iy8cjBnPH-cpufn86ebya3X9_cu3yw_XlZFtM1cA0ko7dOBU3VmHg7Fta5UyXHAnhLIKsBUNwwH6GpFJjh004EwNxhXxKXl3sN2m-GvBPOvJZ4PjCAHjkrWom1o1SvZ9Qd_-h97FJYVynC4BqmV938hCiQNlUsw5odPb5CdIe82ZXqvVh2p1qVU_VKtZEb15tF6GCe1fybHLAsgDkMsq_MD0L_sJ2z--pLTM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2506709953</pqid></control><display><type>article</type><title>Beneficial effects of vitamin D on anxiety and depression-like behaviors induced by unpredictable chronic mild stress by suppression of brain oxidative stress and neuroinflammation in rats</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Bakhtiari-Dovvombaygi, Hossein ; Izadi, Saeed ; Zare Moghaddam, Mostafa ; Hashemzehi, Milad ; Hosseini, Mahmoud ; Azhdari-Zarmehri, Hassan ; Dinpanah, Hossein ; Beheshti, Farimah</creator><creatorcontrib>Bakhtiari-Dovvombaygi, Hossein ; Izadi, Saeed ; Zare Moghaddam, Mostafa ; Hashemzehi, Milad ; Hosseini, Mahmoud ; Azhdari-Zarmehri, Hassan ; Dinpanah, Hossein ; Beheshti, Farimah</creatorcontrib><description>The objective of this study was to investigate the protective effects of vitamin D (Vit D) on anxiety and depression-like behaviors induced by unpredictable chronic mild stress and brain tissue oxidative damage criteria and neuroinflammation in rats. The rats were treated as follows: (1) control, (2) UCMS, (3–5) Vit D 100, 1000, and 10,000 iu + UCMS. Rats were subjected to UCMS for a total of 4 weeks. During week 4, they received seven training trials. The brains were then collected to examine inflammation and oxidative stress criteria. Pretreatment with Vit D enhanced performances of the rats in the elevated plus maze (EPM) and open field (OF) and forced swimming test (FST). UCMS also increased MDA and interleukin-6 (IL-6) levels while decreased CAT, SOD, and thiol. Vit D reversed the effects of UCMS. The results of the current research revealed that Vit D improved UCMS-induced anxiety and depression via decreasing brain oxidative stress and inhibiting neuroinflammation.</description><identifier>ISSN: 0028-1298</identifier><identifier>EISSN: 1432-1912</identifier><identifier>DOI: 10.1007/s00210-020-02002-0</identifier><identifier>PMID: 33106919</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Anxiety ; Anxiety - drug therapy ; Anxiety - metabolism ; Behavior, Animal - drug effects ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Brain - drug effects ; Brain - metabolism ; Brain injury ; Catalase - metabolism ; Depression - drug therapy ; Depression - metabolism ; Inflammation ; Inflammation - drug therapy ; Inflammation - metabolism ; Interleukin 6 ; Interleukin-6 - metabolism ; Male ; Malondialdehyde - metabolism ; Mental depression ; Neurosciences ; Original Article ; Oxidation ; Oxidative stress ; Oxidative Stress - drug effects ; Pharmacology/Toxicology ; Rats ; Rats, Wistar ; Stress, Psychological - drug therapy ; Stress, Psychological - metabolism ; Sulfhydryl Compounds - metabolism ; Superoxide Dismutase - metabolism ; Vitamin D ; Vitamin D - pharmacology ; Vitamin D - therapeutic use ; Vitamins - pharmacology ; Vitamins - therapeutic use</subject><ispartof>Naunyn-Schmiedeberg's archives of pharmacology, 2021-04, Vol.394 (4), p.655-667</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-aa3d3db8af648dfebcd77d66c121f226d6ae7250eba94ee031e8a5afc4acfaa3</citedby><cites>FETCH-LOGICAL-c375t-aa3d3db8af648dfebcd77d66c121f226d6ae7250eba94ee031e8a5afc4acfaa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00210-020-02002-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00210-020-02002-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33106919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakhtiari-Dovvombaygi, Hossein</creatorcontrib><creatorcontrib>Izadi, Saeed</creatorcontrib><creatorcontrib>Zare Moghaddam, Mostafa</creatorcontrib><creatorcontrib>Hashemzehi, Milad</creatorcontrib><creatorcontrib>Hosseini, Mahmoud</creatorcontrib><creatorcontrib>Azhdari-Zarmehri, Hassan</creatorcontrib><creatorcontrib>Dinpanah, Hossein</creatorcontrib><creatorcontrib>Beheshti, Farimah</creatorcontrib><title>Beneficial effects of vitamin D on anxiety and depression-like behaviors induced by unpredictable chronic mild stress by suppression of brain oxidative stress and neuroinflammation in rats</title><title>Naunyn-Schmiedeberg's archives of pharmacology</title><addtitle>Naunyn-Schmiedeberg's Arch Pharmacol</addtitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><description>The objective of this study was to investigate the protective effects of vitamin D (Vit D) on anxiety and depression-like behaviors induced by unpredictable chronic mild stress and brain tissue oxidative damage criteria and neuroinflammation in rats. The rats were treated as follows: (1) control, (2) UCMS, (3–5) Vit D 100, 1000, and 10,000 iu + UCMS. Rats were subjected to UCMS for a total of 4 weeks. During week 4, they received seven training trials. The brains were then collected to examine inflammation and oxidative stress criteria. Pretreatment with Vit D enhanced performances of the rats in the elevated plus maze (EPM) and open field (OF) and forced swimming test (FST). UCMS also increased MDA and interleukin-6 (IL-6) levels while decreased CAT, SOD, and thiol. Vit D reversed the effects of UCMS. The results of the current research revealed that Vit D improved UCMS-induced anxiety and depression via decreasing brain oxidative stress and inhibiting neuroinflammation.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Anxiety</subject><subject>Anxiety - drug therapy</subject><subject>Anxiety - metabolism</subject><subject>Behavior, Animal - drug effects</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain injury</subject><subject>Catalase - metabolism</subject><subject>Depression - drug therapy</subject><subject>Depression - metabolism</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - metabolism</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - metabolism</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Mental depression</subject><subject>Neurosciences</subject><subject>Original Article</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacology/Toxicology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Stress, Psychological - drug therapy</subject><subject>Stress, Psychological - metabolism</subject><subject>Sulfhydryl Compounds - metabolism</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Vitamin D</subject><subject>Vitamin D - pharmacology</subject><subject>Vitamin D - therapeutic use</subject><subject>Vitamins - pharmacology</subject><subject>Vitamins - therapeutic use</subject><issn>0028-1298</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc1u1DAUhS0EokPbF2CBLLFhE-qfxEmW0PInVWLTvXVjX1OXxB7sZNR5Nx4Op9MBiUUX1pV8v3POlQ4hrzl7zxlrLzJjgrOKiYfHRMWekQ2vpah4z8Vzsil_XcVF352QVznfMcYUb5qX5ERKzlTP-w35_REDOm88jBSdQzNnGh3d-RkmH-gVjYFCuPc478u01OI2Yc4-hmr0P5EOeAs7H1OmPtjFoKXDni6hQNabGYYRqblNMXhDJz9amudVvkJ52R6t1sQhQcmL997C7Hd4BNfMgEuKPrgRpqksC1_IBHM-Iy8cjBnPH-cpufn86ebya3X9_cu3yw_XlZFtM1cA0ko7dOBU3VmHg7Fta5UyXHAnhLIKsBUNwwH6GpFJjh004EwNxhXxKXl3sN2m-GvBPOvJZ4PjCAHjkrWom1o1SvZ9Qd_-h97FJYVynC4BqmV938hCiQNlUsw5odPb5CdIe82ZXqvVh2p1qVU_VKtZEb15tF6GCe1fybHLAsgDkMsq_MD0L_sJ2z--pLTM</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Bakhtiari-Dovvombaygi, Hossein</creator><creator>Izadi, Saeed</creator><creator>Zare Moghaddam, Mostafa</creator><creator>Hashemzehi, Milad</creator><creator>Hosseini, Mahmoud</creator><creator>Azhdari-Zarmehri, Hassan</creator><creator>Dinpanah, Hossein</creator><creator>Beheshti, Farimah</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210401</creationdate><title>Beneficial effects of vitamin D on anxiety and depression-like behaviors induced by unpredictable chronic mild stress by suppression of brain oxidative stress and neuroinflammation in rats</title><author>Bakhtiari-Dovvombaygi, Hossein ; Izadi, Saeed ; Zare Moghaddam, Mostafa ; Hashemzehi, Milad ; Hosseini, Mahmoud ; Azhdari-Zarmehri, Hassan ; Dinpanah, Hossein ; Beheshti, Farimah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-aa3d3db8af648dfebcd77d66c121f226d6ae7250eba94ee031e8a5afc4acfaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Anxiety</topic><topic>Anxiety - drug therapy</topic><topic>Anxiety - metabolism</topic><topic>Behavior, Animal - drug effects</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain injury</topic><topic>Catalase - metabolism</topic><topic>Depression - drug therapy</topic><topic>Depression - metabolism</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - metabolism</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - metabolism</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Mental depression</topic><topic>Neurosciences</topic><topic>Original Article</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Pharmacology/Toxicology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stress, Psychological - drug therapy</topic><topic>Stress, Psychological - metabolism</topic><topic>Sulfhydryl Compounds - metabolism</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Vitamin D</topic><topic>Vitamin D - pharmacology</topic><topic>Vitamin D - therapeutic use</topic><topic>Vitamins - pharmacology</topic><topic>Vitamins - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakhtiari-Dovvombaygi, Hossein</creatorcontrib><creatorcontrib>Izadi, Saeed</creatorcontrib><creatorcontrib>Zare Moghaddam, Mostafa</creatorcontrib><creatorcontrib>Hashemzehi, Milad</creatorcontrib><creatorcontrib>Hosseini, Mahmoud</creatorcontrib><creatorcontrib>Azhdari-Zarmehri, Hassan</creatorcontrib><creatorcontrib>Dinpanah, Hossein</creatorcontrib><creatorcontrib>Beheshti, Farimah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakhtiari-Dovvombaygi, Hossein</au><au>Izadi, Saeed</au><au>Zare Moghaddam, Mostafa</au><au>Hashemzehi, Milad</au><au>Hosseini, Mahmoud</au><au>Azhdari-Zarmehri, Hassan</au><au>Dinpanah, Hossein</au><au>Beheshti, Farimah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beneficial effects of vitamin D on anxiety and depression-like behaviors induced by unpredictable chronic mild stress by suppression of brain oxidative stress and neuroinflammation in rats</atitle><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle><stitle>Naunyn-Schmiedeberg's Arch Pharmacol</stitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>394</volume><issue>4</issue><spage>655</spage><epage>667</epage><pages>655-667</pages><issn>0028-1298</issn><eissn>1432-1912</eissn><abstract>The objective of this study was to investigate the protective effects of vitamin D (Vit D) on anxiety and depression-like behaviors induced by unpredictable chronic mild stress and brain tissue oxidative damage criteria and neuroinflammation in rats. The rats were treated as follows: (1) control, (2) UCMS, (3–5) Vit D 100, 1000, and 10,000 iu + UCMS. Rats were subjected to UCMS for a total of 4 weeks. During week 4, they received seven training trials. The brains were then collected to examine inflammation and oxidative stress criteria. Pretreatment with Vit D enhanced performances of the rats in the elevated plus maze (EPM) and open field (OF) and forced swimming test (FST). UCMS also increased MDA and interleukin-6 (IL-6) levels while decreased CAT, SOD, and thiol. Vit D reversed the effects of UCMS. The results of the current research revealed that Vit D improved UCMS-induced anxiety and depression via decreasing brain oxidative stress and inhibiting neuroinflammation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33106919</pmid><doi>10.1007/s00210-020-02002-0</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-1298 |
| ispartof | Naunyn-Schmiedeberg's archives of pharmacology, 2021-04, Vol.394 (4), p.655-667 |
| issn | 0028-1298 1432-1912 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2454656399 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antioxidants - pharmacology Antioxidants - therapeutic use Anxiety Anxiety - drug therapy Anxiety - metabolism Behavior, Animal - drug effects Biomedical and Life Sciences Biomedicine Brain Brain - drug effects Brain - metabolism Brain injury Catalase - metabolism Depression - drug therapy Depression - metabolism Inflammation Inflammation - drug therapy Inflammation - metabolism Interleukin 6 Interleukin-6 - metabolism Male Malondialdehyde - metabolism Mental depression Neurosciences Original Article Oxidation Oxidative stress Oxidative Stress - drug effects Pharmacology/Toxicology Rats Rats, Wistar Stress, Psychological - drug therapy Stress, Psychological - metabolism Sulfhydryl Compounds - metabolism Superoxide Dismutase - metabolism Vitamin D Vitamin D - pharmacology Vitamin D - therapeutic use Vitamins - pharmacology Vitamins - therapeutic use |
| title | Beneficial effects of vitamin D on anxiety and depression-like behaviors induced by unpredictable chronic mild stress by suppression of brain oxidative stress and neuroinflammation in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T15%3A07%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Beneficial%20effects%20of%20vitamin%20D%20on%20anxiety%20and%20depression-like%20behaviors%20induced%20by%20unpredictable%20chronic%20mild%20stress%20by%20suppression%20of%20brain%20oxidative%20stress%20and%20neuroinflammation%20in%20rats&rft.jtitle=Naunyn-Schmiedeberg's%20archives%20of%20pharmacology&rft.au=Bakhtiari-Dovvombaygi,%20Hossein&rft.date=2021-04-01&rft.volume=394&rft.issue=4&rft.spage=655&rft.epage=667&rft.pages=655-667&rft.issn=0028-1298&rft.eissn=1432-1912&rft_id=info:doi/10.1007/s00210-020-02002-0&rft_dat=%3Cproquest_cross%3E2454656399%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2506709953&rft_id=info:pmid/33106919&rfr_iscdi=true |