Telomeric alterations in the default mode network during the progression of Alzheimer’s disease: Selective vulnerability of the precuneus

Aims Although telomere length (TL) and telomere maintenance proteins (shelterins) are markers of cellular senescence and peripheral blood biomarkers of Alzheimer's disease (AD), little information is available on telomeric alterations during the prodromal stage (MCI) of AD. We investigated TL i...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2021-04, Vol.47 (3), p.428-440
Hauptverfasser:	Mahady, Laura J., He, Bin, Malek‐Ahmadi, Michael, Mufson, Elliott J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid Cognitive ability Cortex (frontal) Cortex (parietal) default mode network mild cognitive impairment mRNA Neurodegenerative diseases neurofibrillary tangles Peripheral blood precuneus Proteins Rap1 protein Senescence shelterins Telomere-binding protein Telomeres telosome Temporal cortex TRF2 protein Visual cortex Western blotting
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