New insights on IgA vasculitis with underlying solid tumor: a nationwide French study of 30 patients
Objective IgA vasculitis (IgAV) frequently occurs during or after a mucosal infection; it also rarely occurs in patients with cancer. We hypothesized that cancer could impact the baseline characteristics and/or outcome of vasculitis. We aimed to describe the presentation of IgAV in patients with can...
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| Veröffentlicht in: | Clinical rheumatology 2021-05, Vol.40 (5), p.1933-1940 |
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| creator | Hankard, Antoine Michot, Jean-Marie Terrier, Benjamin Brihaye, Benoît Chanal, Johan Combe, Christian Karras, Alexandre Urbanski, Geoffrey Amoura, Zahir Darrigade, Anne-Sophie Deroux, Alban Guerville, Florent Burel, Le Sébastien Maigné, Gwénola Mekinian, Arsène Moulis, Guillaume Riviere, Etienne Vandamme-Giard, Carole Maillot, Francois De Boysson, Hubert Aouba, Achille Audemard-Verger, Alexandra |
| description | Objective
IgA vasculitis (IgAV) frequently occurs during or after a mucosal infection; it also rarely occurs in patients with cancer. We hypothesized that cancer could impact the baseline characteristics and/or outcome of vasculitis. We aimed to describe the presentation of IgAV in patients with cancer (IgAV ca+) compared to patients without cancer.
Methods
We conducted a nationwide retrospective study of adult patients in France who presented with both IgAV and cancer. Baseline characteristics were described and compared with those of the 260 patients included in a nationwide French IgAV study.
Results
Thirty patients were included. The mean age was 69 ± 12 years; 80% were men. Compared to patients without underlying cancer, IgAV ca+ patients were older (69 ± 12 vs. 50 ± 18 years;
p
|
| doi_str_mv | 10.1007/s10067-020-05455-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2454408404</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2522500536</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-23887e3384e50f51729577097308b2006ddb344eeeba619968cb2b82b1171a803</originalsourceid><addsrcrecordid>eNp9kctOWzEQhq2qVUlpX6ALZKmbbg6Mb7HNDqHSIiG6adfWuUwSoxM72D5E4ekxhBaJBZuZxXzzz-Un5CuDYwagT3KNc90AhwaUVKq5f0dmTArZWCvtezIDraERzJoD8innGwDgxrKP5EAIsFYzNiPDNW6pD9kvVyXTGOjl8ozetbmfRl98pltfVnQKA6Zx58OS5jj6gZZpHdMpbWloi49h6wekFwlDv6K5TMOOxgUVQDe1iqHkz-TDoh0zfnnOh-TvxY8_57-aq98_L8_PrppeaFUaLozRKISRqGChmOZW1QusFmA6Xm8dhk5IiYhdO2fWzk3f8c7wjjHNWgPikHzf625SvJ0wF7f2ucdxbAPGKTsulZRgJMiKfnuF3sQphbqd44pzBaDEvFJ8T_Up5pxw4TbJr9u0cwzcowdu74GrHrgnD9x9bTp6lp66NQ7_W_49vQJiD-RaCktML7PfkH0AwJ2QiA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2522500536</pqid></control><display><type>article</type><title>New insights on IgA vasculitis with underlying solid tumor: a nationwide French study of 30 patients</title><source>SpringerLink Journals - AutoHoldings</source><creator>Hankard, Antoine ; Michot, Jean-Marie ; Terrier, Benjamin ; Brihaye, Benoît ; Chanal, Johan ; Combe, Christian ; Karras, Alexandre ; Urbanski, Geoffrey ; Amoura, Zahir ; Darrigade, Anne-Sophie ; Deroux, Alban ; Guerville, Florent ; Burel, Le Sébastien ; Maigné, Gwénola ; Mekinian, Arsène ; Moulis, Guillaume ; Riviere, Etienne ; Vandamme-Giard, Carole ; Maillot, Francois ; De Boysson, Hubert ; Aouba, Achille ; Audemard-Verger, Alexandra</creator><creatorcontrib>Hankard, Antoine ; Michot, Jean-Marie ; Terrier, Benjamin ; Brihaye, Benoît ; Chanal, Johan ; Combe, Christian ; Karras, Alexandre ; Urbanski, Geoffrey ; Amoura, Zahir ; Darrigade, Anne-Sophie ; Deroux, Alban ; Guerville, Florent ; Burel, Le Sébastien ; Maigné, Gwénola ; Mekinian, Arsène ; Moulis, Guillaume ; Riviere, Etienne ; Vandamme-Giard, Carole ; Maillot, Francois ; De Boysson, Hubert ; Aouba, Achille ; Audemard-Verger, Alexandra ; French Vasculitis Study Group (FVSG) ; on behalf of the French Vasculitis Study Group (FVSG)</creatorcontrib><description>Objective
IgA vasculitis (IgAV) frequently occurs during or after a mucosal infection; it also rarely occurs in patients with cancer. We hypothesized that cancer could impact the baseline characteristics and/or outcome of vasculitis. We aimed to describe the presentation of IgAV in patients with cancer (IgAV ca+) compared to patients without cancer.
Methods
We conducted a nationwide retrospective study of adult patients in France who presented with both IgAV and cancer. Baseline characteristics were described and compared with those of the 260 patients included in a nationwide French IgAV study.
Results
Thirty patients were included. The mean age was 69 ± 12 years; 80% were men. Compared to patients without underlying cancer, IgAV ca+ patients were older (69 ± 12 vs. 50 ± 18 years;
p
< 0.0001) and they presented more frequently with necrotic purpura (53 vs. 26%;
p
< 0.002) and intra-alveolar hemorrhage (10 vs. 0.5%;
p
< 0.0001). IgAV ca+ patients frequently had elevated serum IgA levels (79 vs. 53%;
p
< 0.034); most (
n
= 22, 73%) had adenocarcinoma or urothelial carcinoma involving the large intestines (
n
= 6), bladder (
n
= 5), and lung (
n
= 5). Most IgAV ca+ patients had progressive cancer (
n
= 21); a minority had metastatic disease (
n
= 2) at IgAV diagnosis. After a median follow-up of 3 months, 8 deaths were observed but none was related to IgAV.
Conclusion
Compared to their noncancer counterpart, patients with IgAV related to cancer were older and more frequently presented with necrotizing purpura, intra-alveolar hemorrhage, and elevated serum IgA levels. Adult patients with IgAV and these latter characteristics should be carefully screened for cancer.
Key Points
•
Clinical and biological characteristics of patients presenting with IgAV are distinct depending on the underlying cause of vasculitis related to cancer.
•
Patients with IgAV related to cancer are older, and compared to their counterparts without IgAV, they present more frequently with necrotic purpura, alveolar hemorrhage, and elevated serum IgA levels.
•
All adult patients with IgAV should be screened for cancer, and there should be a focus on elderly male patients presenting with necrotic purpura and/or alveolar hemorrhage.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-020-05455-z</identifier><identifier>PMID: 33099711</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adenocarcinoma ; Alveoli ; Bladder cancer ; Cancer ; Hemorrhage ; Immunoglobulin A ; Medicine ; Medicine & Public Health ; Metastases ; Mucosa ; Original Article ; Purpura ; Rheumatology ; Solid tumors ; Urothelial carcinoma ; Vasculitis</subject><ispartof>Clinical rheumatology, 2021-05, Vol.40 (5), p.1933-1940</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2020</rights><rights>International League of Associations for Rheumatology (ILAR) 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-23887e3384e50f51729577097308b2006ddb344eeeba619968cb2b82b1171a803</citedby><cites>FETCH-LOGICAL-c375t-23887e3384e50f51729577097308b2006ddb344eeeba619968cb2b82b1171a803</cites><orcidid>0000-0002-0226-5016 ; 0000-0003-2305-7117</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-020-05455-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-020-05455-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33099711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hankard, Antoine</creatorcontrib><creatorcontrib>Michot, Jean-Marie</creatorcontrib><creatorcontrib>Terrier, Benjamin</creatorcontrib><creatorcontrib>Brihaye, Benoît</creatorcontrib><creatorcontrib>Chanal, Johan</creatorcontrib><creatorcontrib>Combe, Christian</creatorcontrib><creatorcontrib>Karras, Alexandre</creatorcontrib><creatorcontrib>Urbanski, Geoffrey</creatorcontrib><creatorcontrib>Amoura, Zahir</creatorcontrib><creatorcontrib>Darrigade, Anne-Sophie</creatorcontrib><creatorcontrib>Deroux, Alban</creatorcontrib><creatorcontrib>Guerville, Florent</creatorcontrib><creatorcontrib>Burel, Le Sébastien</creatorcontrib><creatorcontrib>Maigné, Gwénola</creatorcontrib><creatorcontrib>Mekinian, Arsène</creatorcontrib><creatorcontrib>Moulis, Guillaume</creatorcontrib><creatorcontrib>Riviere, Etienne</creatorcontrib><creatorcontrib>Vandamme-Giard, Carole</creatorcontrib><creatorcontrib>Maillot, Francois</creatorcontrib><creatorcontrib>De Boysson, Hubert</creatorcontrib><creatorcontrib>Aouba, Achille</creatorcontrib><creatorcontrib>Audemard-Verger, Alexandra</creatorcontrib><creatorcontrib>French Vasculitis Study Group (FVSG)</creatorcontrib><creatorcontrib>on behalf of the French Vasculitis Study Group (FVSG)</creatorcontrib><title>New insights on IgA vasculitis with underlying solid tumor: a nationwide French study of 30 patients</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Objective
IgA vasculitis (IgAV) frequently occurs during or after a mucosal infection; it also rarely occurs in patients with cancer. We hypothesized that cancer could impact the baseline characteristics and/or outcome of vasculitis. We aimed to describe the presentation of IgAV in patients with cancer (IgAV ca+) compared to patients without cancer.
Methods
We conducted a nationwide retrospective study of adult patients in France who presented with both IgAV and cancer. Baseline characteristics were described and compared with those of the 260 patients included in a nationwide French IgAV study.
Results
Thirty patients were included. The mean age was 69 ± 12 years; 80% were men. Compared to patients without underlying cancer, IgAV ca+ patients were older (69 ± 12 vs. 50 ± 18 years;
p
< 0.0001) and they presented more frequently with necrotic purpura (53 vs. 26%;
p
< 0.002) and intra-alveolar hemorrhage (10 vs. 0.5%;
p
< 0.0001). IgAV ca+ patients frequently had elevated serum IgA levels (79 vs. 53%;
p
< 0.034); most (
n
= 22, 73%) had adenocarcinoma or urothelial carcinoma involving the large intestines (
n
= 6), bladder (
n
= 5), and lung (
n
= 5). Most IgAV ca+ patients had progressive cancer (
n
= 21); a minority had metastatic disease (
n
= 2) at IgAV diagnosis. After a median follow-up of 3 months, 8 deaths were observed but none was related to IgAV.
Conclusion
Compared to their noncancer counterpart, patients with IgAV related to cancer were older and more frequently presented with necrotizing purpura, intra-alveolar hemorrhage, and elevated serum IgA levels. Adult patients with IgAV and these latter characteristics should be carefully screened for cancer.
Key Points
•
Clinical and biological characteristics of patients presenting with IgAV are distinct depending on the underlying cause of vasculitis related to cancer.
•
Patients with IgAV related to cancer are older, and compared to their counterparts without IgAV, they present more frequently with necrotic purpura, alveolar hemorrhage, and elevated serum IgA levels.
•
All adult patients with IgAV should be screened for cancer, and there should be a focus on elderly male patients presenting with necrotic purpura and/or alveolar hemorrhage.</description><subject>Adenocarcinoma</subject><subject>Alveoli</subject><subject>Bladder cancer</subject><subject>Cancer</subject><subject>Hemorrhage</subject><subject>Immunoglobulin A</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Mucosa</subject><subject>Original Article</subject><subject>Purpura</subject><subject>Rheumatology</subject><subject>Solid tumors</subject><subject>Urothelial carcinoma</subject><subject>Vasculitis</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctOWzEQhq2qVUlpX6ALZKmbbg6Mb7HNDqHSIiG6adfWuUwSoxM72D5E4ekxhBaJBZuZxXzzz-Un5CuDYwagT3KNc90AhwaUVKq5f0dmTArZWCvtezIDraERzJoD8innGwDgxrKP5EAIsFYzNiPDNW6pD9kvVyXTGOjl8ozetbmfRl98pltfVnQKA6Zx58OS5jj6gZZpHdMpbWloi49h6wekFwlDv6K5TMOOxgUVQDe1iqHkz-TDoh0zfnnOh-TvxY8_57-aq98_L8_PrppeaFUaLozRKISRqGChmOZW1QusFmA6Xm8dhk5IiYhdO2fWzk3f8c7wjjHNWgPikHzf625SvJ0wF7f2ucdxbAPGKTsulZRgJMiKfnuF3sQphbqd44pzBaDEvFJ8T_Up5pxw4TbJr9u0cwzcowdu74GrHrgnD9x9bTp6lp66NQ7_W_49vQJiD-RaCktML7PfkH0AwJ2QiA</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Hankard, Antoine</creator><creator>Michot, Jean-Marie</creator><creator>Terrier, Benjamin</creator><creator>Brihaye, Benoît</creator><creator>Chanal, Johan</creator><creator>Combe, Christian</creator><creator>Karras, Alexandre</creator><creator>Urbanski, Geoffrey</creator><creator>Amoura, Zahir</creator><creator>Darrigade, Anne-Sophie</creator><creator>Deroux, Alban</creator><creator>Guerville, Florent</creator><creator>Burel, Le Sébastien</creator><creator>Maigné, Gwénola</creator><creator>Mekinian, Arsène</creator><creator>Moulis, Guillaume</creator><creator>Riviere, Etienne</creator><creator>Vandamme-Giard, Carole</creator><creator>Maillot, Francois</creator><creator>De Boysson, Hubert</creator><creator>Aouba, Achille</creator><creator>Audemard-Verger, Alexandra</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0226-5016</orcidid><orcidid>https://orcid.org/0000-0003-2305-7117</orcidid></search><sort><creationdate>20210501</creationdate><title>New insights on IgA vasculitis with underlying solid tumor: a nationwide French study of 30 patients</title><author>Hankard, Antoine ; Michot, Jean-Marie ; Terrier, Benjamin ; Brihaye, Benoît ; Chanal, Johan ; Combe, Christian ; Karras, Alexandre ; Urbanski, Geoffrey ; Amoura, Zahir ; Darrigade, Anne-Sophie ; Deroux, Alban ; Guerville, Florent ; Burel, Le Sébastien ; Maigné, Gwénola ; Mekinian, Arsène ; Moulis, Guillaume ; Riviere, Etienne ; Vandamme-Giard, Carole ; Maillot, Francois ; De Boysson, Hubert ; Aouba, Achille ; Audemard-Verger, Alexandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-23887e3384e50f51729577097308b2006ddb344eeeba619968cb2b82b1171a803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adenocarcinoma</topic><topic>Alveoli</topic><topic>Bladder cancer</topic><topic>Cancer</topic><topic>Hemorrhage</topic><topic>Immunoglobulin A</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Mucosa</topic><topic>Original Article</topic><topic>Purpura</topic><topic>Rheumatology</topic><topic>Solid tumors</topic><topic>Urothelial carcinoma</topic><topic>Vasculitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hankard, Antoine</creatorcontrib><creatorcontrib>Michot, Jean-Marie</creatorcontrib><creatorcontrib>Terrier, Benjamin</creatorcontrib><creatorcontrib>Brihaye, Benoît</creatorcontrib><creatorcontrib>Chanal, Johan</creatorcontrib><creatorcontrib>Combe, Christian</creatorcontrib><creatorcontrib>Karras, Alexandre</creatorcontrib><creatorcontrib>Urbanski, Geoffrey</creatorcontrib><creatorcontrib>Amoura, Zahir</creatorcontrib><creatorcontrib>Darrigade, Anne-Sophie</creatorcontrib><creatorcontrib>Deroux, Alban</creatorcontrib><creatorcontrib>Guerville, Florent</creatorcontrib><creatorcontrib>Burel, Le Sébastien</creatorcontrib><creatorcontrib>Maigné, Gwénola</creatorcontrib><creatorcontrib>Mekinian, Arsène</creatorcontrib><creatorcontrib>Moulis, Guillaume</creatorcontrib><creatorcontrib>Riviere, Etienne</creatorcontrib><creatorcontrib>Vandamme-Giard, Carole</creatorcontrib><creatorcontrib>Maillot, Francois</creatorcontrib><creatorcontrib>De Boysson, Hubert</creatorcontrib><creatorcontrib>Aouba, Achille</creatorcontrib><creatorcontrib>Audemard-Verger, Alexandra</creatorcontrib><creatorcontrib>French Vasculitis Study Group (FVSG)</creatorcontrib><creatorcontrib>on behalf of the French Vasculitis Study Group (FVSG)</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hankard, Antoine</au><au>Michot, Jean-Marie</au><au>Terrier, Benjamin</au><au>Brihaye, Benoît</au><au>Chanal, Johan</au><au>Combe, Christian</au><au>Karras, Alexandre</au><au>Urbanski, Geoffrey</au><au>Amoura, Zahir</au><au>Darrigade, Anne-Sophie</au><au>Deroux, Alban</au><au>Guerville, Florent</au><au>Burel, Le Sébastien</au><au>Maigné, Gwénola</au><au>Mekinian, Arsène</au><au>Moulis, Guillaume</au><au>Riviere, Etienne</au><au>Vandamme-Giard, Carole</au><au>Maillot, Francois</au><au>De Boysson, Hubert</au><au>Aouba, Achille</au><au>Audemard-Verger, Alexandra</au><aucorp>French Vasculitis Study Group (FVSG)</aucorp><aucorp>on behalf of the French Vasculitis Study Group (FVSG)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New insights on IgA vasculitis with underlying solid tumor: a nationwide French study of 30 patients</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>40</volume><issue>5</issue><spage>1933</spage><epage>1940</epage><pages>1933-1940</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>Objective
IgA vasculitis (IgAV) frequently occurs during or after a mucosal infection; it also rarely occurs in patients with cancer. We hypothesized that cancer could impact the baseline characteristics and/or outcome of vasculitis. We aimed to describe the presentation of IgAV in patients with cancer (IgAV ca+) compared to patients without cancer.
Methods
We conducted a nationwide retrospective study of adult patients in France who presented with both IgAV and cancer. Baseline characteristics were described and compared with those of the 260 patients included in a nationwide French IgAV study.
Results
Thirty patients were included. The mean age was 69 ± 12 years; 80% were men. Compared to patients without underlying cancer, IgAV ca+ patients were older (69 ± 12 vs. 50 ± 18 years;
p
< 0.0001) and they presented more frequently with necrotic purpura (53 vs. 26%;
p
< 0.002) and intra-alveolar hemorrhage (10 vs. 0.5%;
p
< 0.0001). IgAV ca+ patients frequently had elevated serum IgA levels (79 vs. 53%;
p
< 0.034); most (
n
= 22, 73%) had adenocarcinoma or urothelial carcinoma involving the large intestines (
n
= 6), bladder (
n
= 5), and lung (
n
= 5). Most IgAV ca+ patients had progressive cancer (
n
= 21); a minority had metastatic disease (
n
= 2) at IgAV diagnosis. After a median follow-up of 3 months, 8 deaths were observed but none was related to IgAV.
Conclusion
Compared to their noncancer counterpart, patients with IgAV related to cancer were older and more frequently presented with necrotizing purpura, intra-alveolar hemorrhage, and elevated serum IgA levels. Adult patients with IgAV and these latter characteristics should be carefully screened for cancer.
Key Points
•
Clinical and biological characteristics of patients presenting with IgAV are distinct depending on the underlying cause of vasculitis related to cancer.
•
Patients with IgAV related to cancer are older, and compared to their counterparts without IgAV, they present more frequently with necrotic purpura, alveolar hemorrhage, and elevated serum IgA levels.
•
All adult patients with IgAV should be screened for cancer, and there should be a focus on elderly male patients presenting with necrotic purpura and/or alveolar hemorrhage.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33099711</pmid><doi>10.1007/s10067-020-05455-z</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0226-5016</orcidid><orcidid>https://orcid.org/0000-0003-2305-7117</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical rheumatology, 2021-05, Vol.40 (5), p.1933-1940 |
| issn | 0770-3198 1434-9949 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2454408404 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Adenocarcinoma Alveoli Bladder cancer Cancer Hemorrhage Immunoglobulin A Medicine Medicine & Public Health Metastases Mucosa Original Article Purpura Rheumatology Solid tumors Urothelial carcinoma Vasculitis |
| title | New insights on IgA vasculitis with underlying solid tumor: a nationwide French study of 30 patients |
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