Production of functional human nerve growth factor from the submandibular glands of mice using a CRISPR/Cas9 genome editing system

Nerve growth factor (NGF) is an essential trophic factor for the growth and survival of neurons in the central and peripheral nervous systems. For many years, mouse NGF (mNGF) has been used to treat various neuronal and non-neuronal disorders. However, the biological activity of human NGF (hNGF) is...

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Veröffentlicht in:	World journal of microbiology & biotechnology 2020-12, Vol.36 (12), p.176-176, Article 176
Hauptverfasser:	Gu, Yi, Cao, Hui, Li, Fei, Yu, Jianli, Nian, Rui, Feng, Dongxiao, Lin, Jingtao, Song, Haipeng, Liu, Wenshuai
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied Microbiology Biochemistry Biological activity Biomedical and Life Sciences Biotechnology Cell proliferation Chromatography CRISPR Edman degradation Environmental Engineering/Biotechnology Exocrine glands Fluorescence Genome editing Genomes Glands Growth factors Ion exchange Ion-exchange chromatography Life Sciences Microbiology Nerve growth factor Original Paper Size exclusion chromatography Submandibular gland Transgenic animals Transgenic mice
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