Safety profile of high molecular weight polymerized hemoglobins

Background Hemoglobin (Hb)‐based oxygen (O2) carriers (HBOCs) are being developed as alternatives to red blood cells and blood when these products are unavailable. Clinical trials of previous HBOC generations revealed side effects, including hypertension and vasoconstriction, that were not observed...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2021-01, Vol.61 (1), p.212-224
Hauptverfasser:	Muller, Cynthia R., Williams, Alexander T., Munoz, Carlos J., Eaker, Allyn M., Breton, Amanda N., Palmer, Andre F., Cabrales, Pedro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute effects Affinity Carrying capacity Clinical trials Erythrocytes Evaluation Guinea pigs Hamsters Heart Hemoglobin Hypertension Inflammation Microvasculature Molecular weight Polymerization Safety Side effects Transfusion Trauma Vasoconstriction
Online-Zugang:	Volltext
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