Cross-sectional imaging in patients with primary sclerosing cholangitis: Single time-point liver or spleen volume is associated with survival
To evaluate the association between single time-point quantitative liver and spleen volumes in patients with PSC and transplant-free survival, independent of Mayo risk score. This HIPAA-compliant retrospective study included 165 PSC patients in a hospital. Total (T), and lobar (right [R], left [L],...
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| Veröffentlicht in: | European journal of radiology 2020-11, Vol.132, p.109331-109331, Article 109331 |
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| creator | Khoshpouri, Pegah Ghadimi, Maryam Rezvani Habibabadi, Roya Motaghi, Mina Venkatesh, Bharath Ambale Shaghaghi, Mohammadreza Pandey, Ankur Hazhirkarzar, Bita Ameli, Sanaz Ghasabeh, Mounes Aliyari Pandey, Pallavi Kamel, Ihab R. |
| description | To evaluate the association between single time-point quantitative liver and spleen volumes in patients with PSC and transplant-free survival, independent of Mayo risk score.
This HIPAA-compliant retrospective study included 165 PSC patients in a hospital. Total (T), and lobar (right [R], left [L], and caudate [C]) liver volumes and spleen volume (S) were measured. Adverse outcome was identified as being on liver transplantation list, transplantation or death (outcome 1), and transplantation or death (outcome 2). Cox-regression was performed to assess the predictive value of volumetric parameters to predict transplant-free survival with and without Mayo risk score. Stratified analysis by Mayo risk score categories was performed to assess the discriminative value of volumes in the model. Prediction models were developed dependent of Mayo score, based on patients demographics, lab values and volumetric measures for both defined outcomes. Kaplan-Meier curves were depicted for different liver and spleen volumes. P value |
| doi_str_mv | 10.1016/j.ejrad.2020.109331 |
| format | Article |
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This HIPAA-compliant retrospective study included 165 PSC patients in a hospital. Total (T), and lobar (right [R], left [L], and caudate [C]) liver volumes and spleen volume (S) were measured. Adverse outcome was identified as being on liver transplantation list, transplantation or death (outcome 1), and transplantation or death (outcome 2). Cox-regression was performed to assess the predictive value of volumetric parameters to predict transplant-free survival with and without Mayo risk score. Stratified analysis by Mayo risk score categories was performed to assess the discriminative value of volumes in the model. Prediction models were developed dependent of Mayo score, based on patients demographics, lab values and volumetric measures for both defined outcomes. Kaplan-Meier curves were depicted for different liver and spleen volumes. P value <0.05 was considered statistically significant.
In this cohort (age 43 ± 17 years; 59 % men) 51 % of patients had adverse outcome. Cox-regression analysis demonstrated statistically significant association between values of T, L, R, C, S, L/T, and C/T and outcome 1; and also statistically significant association between values C, S, and C/T and outcome 2. Prediction models included age, INR, total bilirubin, AST, variceal bleeding, S, and C for outcome 1 and age, INR, total bilirubin, AST, variceal bleeding, and S for outcome 2.
Based on our observational study, quantitative liver and spleen volumes may be associated with transplant-free survival in patients with PSC and may have the potential for predicting the outcome but this should be validated by randomized clinical trial studies.</description><identifier>ISSN: 0720-048X</identifier><identifier>EISSN: 1872-7727</identifier><identifier>DOI: 10.1016/j.ejrad.2020.109331</identifier><identifier>PMID: 33091863</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Cholangiopancreatography, Magnetic Resonance ; Cholangitis, Sclerosing - mortality ; Female ; Humans ; Liver - diagnostic imaging ; Liver transplantation ; Magnetic Resonance Imaging ; Male ; Radiologic ; Retrospective Studies ; Risk ; Risk Assessment - methods ; Spleen - diagnostic imaging ; Surrogate marker ; Tomography, X-Ray Computed</subject><ispartof>European journal of radiology, 2020-11, Vol.132, p.109331-109331, Article 109331</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-b1dad4036227d10aff436a23c6729810025ed644f6bf9fa237954acb66db0133</citedby><cites>FETCH-LOGICAL-c359t-b1dad4036227d10aff436a23c6729810025ed644f6bf9fa237954acb66db0133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0720048X20305209$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33091863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khoshpouri, Pegah</creatorcontrib><creatorcontrib>Ghadimi, Maryam</creatorcontrib><creatorcontrib>Rezvani Habibabadi, Roya</creatorcontrib><creatorcontrib>Motaghi, Mina</creatorcontrib><creatorcontrib>Venkatesh, Bharath Ambale</creatorcontrib><creatorcontrib>Shaghaghi, Mohammadreza</creatorcontrib><creatorcontrib>Pandey, Ankur</creatorcontrib><creatorcontrib>Hazhirkarzar, Bita</creatorcontrib><creatorcontrib>Ameli, Sanaz</creatorcontrib><creatorcontrib>Ghasabeh, Mounes Aliyari</creatorcontrib><creatorcontrib>Pandey, Pallavi</creatorcontrib><creatorcontrib>Kamel, Ihab R.</creatorcontrib><title>Cross-sectional imaging in patients with primary sclerosing cholangitis: Single time-point liver or spleen volume is associated with survival</title><title>European journal of radiology</title><addtitle>Eur J Radiol</addtitle><description>To evaluate the association between single time-point quantitative liver and spleen volumes in patients with PSC and transplant-free survival, independent of Mayo risk score.
This HIPAA-compliant retrospective study included 165 PSC patients in a hospital. Total (T), and lobar (right [R], left [L], and caudate [C]) liver volumes and spleen volume (S) were measured. Adverse outcome was identified as being on liver transplantation list, transplantation or death (outcome 1), and transplantation or death (outcome 2). Cox-regression was performed to assess the predictive value of volumetric parameters to predict transplant-free survival with and without Mayo risk score. Stratified analysis by Mayo risk score categories was performed to assess the discriminative value of volumes in the model. Prediction models were developed dependent of Mayo score, based on patients demographics, lab values and volumetric measures for both defined outcomes. Kaplan-Meier curves were depicted for different liver and spleen volumes. P value <0.05 was considered statistically significant.
In this cohort (age 43 ± 17 years; 59 % men) 51 % of patients had adverse outcome. Cox-regression analysis demonstrated statistically significant association between values of T, L, R, C, S, L/T, and C/T and outcome 1; and also statistically significant association between values C, S, and C/T and outcome 2. Prediction models included age, INR, total bilirubin, AST, variceal bleeding, S, and C for outcome 1 and age, INR, total bilirubin, AST, variceal bleeding, and S for outcome 2.
Based on our observational study, quantitative liver and spleen volumes may be associated with transplant-free survival in patients with PSC and may have the potential for predicting the outcome but this should be validated by randomized clinical trial studies.</description><subject>Adult</subject><subject>Cholangiopancreatography, Magnetic Resonance</subject><subject>Cholangitis, Sclerosing - mortality</subject><subject>Female</subject><subject>Humans</subject><subject>Liver - diagnostic imaging</subject><subject>Liver transplantation</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Radiologic</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Risk Assessment - methods</subject><subject>Spleen - diagnostic imaging</subject><subject>Surrogate marker</subject><subject>Tomography, X-Ray Computed</subject><issn>0720-048X</issn><issn>1872-7727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS0EoreFJ0BCXrLJxX_5Q2KBrqAgVeqiXXRnOfbk1ldOHGwnFQ_BO-OQC8uuRpr5zozmHITeUbKnhFYfT3s4BWX2jLC103JOX6AdbWpW1DWrX6IdqRkpiGgeLtBljCdCSCla9hpdcE5a2lR8h34fgo-xiKCT9aNy2A7qaMcjtiOeVLIwpoifbHrEU8ij8AtH7SBrVkY_eqfGo002fsJ3ueMAJztAMXk7JuzsAgH7gOPkAEa8eDcPgG3EKkavrUpgtt1xDotdlHuDXvXKRXh7rlfo_tvX-8P34ub2-sfhy02hedmmoqNGGUF4xVhtKFF9L3ilGNdVzdqGEsJKMJUQfdX1bZ8HdVsKpbuqMh2hnF-hD9vaKfifM8QkBxs1uPwM-DlKJkpBS9a0ZUb5hurVpwC9PPsgKZFrDPIk_8Yg1xjkFkNWvT8fmLsBzH_NP98z8HkDIH-5WAgy6uy1BmNDjkIab5898AdZWZzr</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Khoshpouri, Pegah</creator><creator>Ghadimi, Maryam</creator><creator>Rezvani Habibabadi, Roya</creator><creator>Motaghi, Mina</creator><creator>Venkatesh, Bharath Ambale</creator><creator>Shaghaghi, Mohammadreza</creator><creator>Pandey, Ankur</creator><creator>Hazhirkarzar, Bita</creator><creator>Ameli, Sanaz</creator><creator>Ghasabeh, Mounes Aliyari</creator><creator>Pandey, Pallavi</creator><creator>Kamel, Ihab R.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202011</creationdate><title>Cross-sectional imaging in patients with primary sclerosing cholangitis: Single time-point liver or spleen volume is associated with survival</title><author>Khoshpouri, Pegah ; Ghadimi, Maryam ; Rezvani Habibabadi, Roya ; Motaghi, Mina ; Venkatesh, Bharath Ambale ; Shaghaghi, Mohammadreza ; Pandey, Ankur ; Hazhirkarzar, Bita ; Ameli, Sanaz ; Ghasabeh, Mounes Aliyari ; Pandey, Pallavi ; Kamel, Ihab R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-b1dad4036227d10aff436a23c6729810025ed644f6bf9fa237954acb66db0133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Cholangiopancreatography, Magnetic Resonance</topic><topic>Cholangitis, Sclerosing - mortality</topic><topic>Female</topic><topic>Humans</topic><topic>Liver - diagnostic imaging</topic><topic>Liver transplantation</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Radiologic</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Risk Assessment - methods</topic><topic>Spleen - diagnostic imaging</topic><topic>Surrogate marker</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khoshpouri, Pegah</creatorcontrib><creatorcontrib>Ghadimi, Maryam</creatorcontrib><creatorcontrib>Rezvani Habibabadi, Roya</creatorcontrib><creatorcontrib>Motaghi, Mina</creatorcontrib><creatorcontrib>Venkatesh, Bharath Ambale</creatorcontrib><creatorcontrib>Shaghaghi, Mohammadreza</creatorcontrib><creatorcontrib>Pandey, Ankur</creatorcontrib><creatorcontrib>Hazhirkarzar, Bita</creatorcontrib><creatorcontrib>Ameli, Sanaz</creatorcontrib><creatorcontrib>Ghasabeh, Mounes Aliyari</creatorcontrib><creatorcontrib>Pandey, Pallavi</creatorcontrib><creatorcontrib>Kamel, Ihab R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khoshpouri, Pegah</au><au>Ghadimi, Maryam</au><au>Rezvani Habibabadi, Roya</au><au>Motaghi, Mina</au><au>Venkatesh, Bharath Ambale</au><au>Shaghaghi, Mohammadreza</au><au>Pandey, Ankur</au><au>Hazhirkarzar, Bita</au><au>Ameli, Sanaz</au><au>Ghasabeh, Mounes Aliyari</au><au>Pandey, Pallavi</au><au>Kamel, Ihab R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cross-sectional imaging in patients with primary sclerosing cholangitis: Single time-point liver or spleen volume is associated with survival</atitle><jtitle>European journal of radiology</jtitle><addtitle>Eur J Radiol</addtitle><date>2020-11</date><risdate>2020</risdate><volume>132</volume><spage>109331</spage><epage>109331</epage><pages>109331-109331</pages><artnum>109331</artnum><issn>0720-048X</issn><eissn>1872-7727</eissn><abstract>To evaluate the association between single time-point quantitative liver and spleen volumes in patients with PSC and transplant-free survival, independent of Mayo risk score.
This HIPAA-compliant retrospective study included 165 PSC patients in a hospital. Total (T), and lobar (right [R], left [L], and caudate [C]) liver volumes and spleen volume (S) were measured. Adverse outcome was identified as being on liver transplantation list, transplantation or death (outcome 1), and transplantation or death (outcome 2). Cox-regression was performed to assess the predictive value of volumetric parameters to predict transplant-free survival with and without Mayo risk score. Stratified analysis by Mayo risk score categories was performed to assess the discriminative value of volumes in the model. Prediction models were developed dependent of Mayo score, based on patients demographics, lab values and volumetric measures for both defined outcomes. Kaplan-Meier curves were depicted for different liver and spleen volumes. P value <0.05 was considered statistically significant.
In this cohort (age 43 ± 17 years; 59 % men) 51 % of patients had adverse outcome. Cox-regression analysis demonstrated statistically significant association between values of T, L, R, C, S, L/T, and C/T and outcome 1; and also statistically significant association between values C, S, and C/T and outcome 2. Prediction models included age, INR, total bilirubin, AST, variceal bleeding, S, and C for outcome 1 and age, INR, total bilirubin, AST, variceal bleeding, and S for outcome 2.
Based on our observational study, quantitative liver and spleen volumes may be associated with transplant-free survival in patients with PSC and may have the potential for predicting the outcome but this should be validated by randomized clinical trial studies.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>33091863</pmid><doi>10.1016/j.ejrad.2020.109331</doi><tpages>1</tpages></addata></record> |
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| ispartof | European journal of radiology, 2020-11, Vol.132, p.109331-109331, Article 109331 |
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| subjects | Adult Cholangiopancreatography, Magnetic Resonance Cholangitis, Sclerosing - mortality Female Humans Liver - diagnostic imaging Liver transplantation Magnetic Resonance Imaging Male Radiologic Retrospective Studies Risk Risk Assessment - methods Spleen - diagnostic imaging Surrogate marker Tomography, X-Ray Computed |
| title | Cross-sectional imaging in patients with primary sclerosing cholangitis: Single time-point liver or spleen volume is associated with survival |
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