Clinical outcomes and long‐term prognosis of perianal Crohn's disease in an Asian population
Background and Aim The clinical impact of perianal Crohn's disease (CD) (pCD), a well‐known poor prognostic factor of CD, has not been fully evaluated in Asian patients. We investigated the outcomes of CD in Korean patients according to the presence of pCD at CD diagnosis. Methods Using 2010–20...
Gespeichert in:
| Veröffentlicht in: | Journal of gastroenterology and hepatology 2021-06, Vol.36 (6), p.1571-1579 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1579 |
|---|---|
| container_issue | 6 |
| container_start_page | 1571 |
| container_title | Journal of gastroenterology and hepatology |
| container_volume | 36 |
| creator | Song, Eun Mi Lee, Ho‐Su Kim, Ye‐Jee Oh, Eun Hye Ham, Nam Seok Kim, Jeongseok Hwang, Sung Wook Park, Sang Hyoung Yang, Dong‐Hoon Ye, Byong Duk Byeon, Jeong‐Sik Myung, Seung‐Jae Yang, Suk‐Kyun |
| description | Background and Aim
The clinical impact of perianal Crohn's disease (CD) (pCD), a well‐known poor prognostic factor of CD, has not been fully evaluated in Asian patients. We investigated the outcomes of CD in Korean patients according to the presence of pCD at CD diagnosis.
Methods
Using 2010–2014 data from the national health insurance claims database, we evaluated the disease course of CD according to the presence of pCD at CD diagnosis. The results were verified in a hospital‐based cohort of 2923 patients.
Results
The cumulative risk of intestinal resection was lower in patients with pCD at diagnosis than in those without, in the population‐based cohort (9.1% vs 14.7% at 5 years after diagnosis, P |
| doi_str_mv | 10.1111/jgh.15308 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2454131342</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2539051927</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3308-543970f0d7247b64171dc7ff1e74788272701b3a59be03320811d8c681bc49e33</originalsourceid><addsrcrecordid>eNp10LFOwzAQBmALgUQpDLyBJQZgCPXFTp2MVQQtqBILrERO4rSuHDvYiVA3HoFn5EkwhAmJWzzcd9bdj9A5kBsINdtttjeQUJIeoAkwRiLgbH6IJiSFJMooZMfoxPsdIYQRnkzQS66VUZXQ2A59ZVvpsTA11tZsPt8_eula3Dm7MdYrj22DO-mUMIHnzm7Npce18lJ4iZUJg3jhQxd3thu06JU1p-ioEdrLs993ip7vbp_yVbR-XN7ni3VU0bBrlDCacdKQmseMl3MGHOqKNw1IzniaxjzmBEoqkqyUhNI4XAN1Ws1TKCuWSUqn6Gr8Nyz7OkjfF63yldRaGGkHX8QsYUCBsjjQiz90ZwcXTgoqoRlJIIt5UNejqpz13smm6JxqhdsXQIrvpIuQdPGTdLCz0b4pLff_w-JhuRonvgD8QH6Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2539051927</pqid></control><display><type>article</type><title>Clinical outcomes and long‐term prognosis of perianal Crohn's disease in an Asian population</title><source>Access via Wiley Online Library</source><creator>Song, Eun Mi ; Lee, Ho‐Su ; Kim, Ye‐Jee ; Oh, Eun Hye ; Ham, Nam Seok ; Kim, Jeongseok ; Hwang, Sung Wook ; Park, Sang Hyoung ; Yang, Dong‐Hoon ; Ye, Byong Duk ; Byeon, Jeong‐Sik ; Myung, Seung‐Jae ; Yang, Suk‐Kyun</creator><creatorcontrib>Song, Eun Mi ; Lee, Ho‐Su ; Kim, Ye‐Jee ; Oh, Eun Hye ; Ham, Nam Seok ; Kim, Jeongseok ; Hwang, Sung Wook ; Park, Sang Hyoung ; Yang, Dong‐Hoon ; Ye, Byong Duk ; Byeon, Jeong‐Sik ; Myung, Seung‐Jae ; Yang, Suk‐Kyun</creatorcontrib><description>Background and Aim
The clinical impact of perianal Crohn's disease (CD) (pCD), a well‐known poor prognostic factor of CD, has not been fully evaluated in Asian patients. We investigated the outcomes of CD in Korean patients according to the presence of pCD at CD diagnosis.
Methods
Using 2010–2014 data from the national health insurance claims database, we evaluated the disease course of CD according to the presence of pCD at CD diagnosis. The results were verified in a hospital‐based cohort of 2923 patients.
Results
The cumulative risk of intestinal resection was lower in patients with pCD at diagnosis than in those without, in the population‐based cohort (9.1% vs 14.7% at 5 years after diagnosis, P < 0.001), but it was similar between the two groups in the hospital‐based cohort (36.8% vs 36.8% at 10 years after diagnosis, P = 0.950). Moreover, the cumulative risk of behavioral progression was not significantly different between the two groups in the hospital‐based cohort (43.4% vs 41.6% at 10 years after diagnosis, P = 0.366). On multivariable analysis, pCD at CD diagnosis was not a predictor of intestinal resection, behavioral progression, CD‐related hospital admission, or diverting surgery; however, it was an independent predictor of proctectomy (hazard ratio [HR] 3.210, P < 0.001) and anorectal cancer (HR 3.104, P = 0.047).
Conclusions
Although the presence of pCD increased the risk of proctectomy and anorectal cancer in Asian patients, the clinical impact of pCD on the overall outcomes of patients with CD may be less significant in Asian patients compared with Western patients.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.15308</identifier><language>eng</language><publisher>Richmond: Wiley Subscription Services, Inc</publisher><subject>Anorectal ; Clinical outcomes ; Crohn's disease ; Diagnosis ; Intestine ; Patients ; Perianal fistula ; Prognosis ; Surgery</subject><ispartof>Journal of gastroenterology and hepatology, 2021-06, Vol.36 (6), p.1571-1579</ispartof><rights>2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><rights>2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3308-543970f0d7247b64171dc7ff1e74788272701b3a59be03320811d8c681bc49e33</citedby><cites>FETCH-LOGICAL-c3308-543970f0d7247b64171dc7ff1e74788272701b3a59be03320811d8c681bc49e33</cites><orcidid>0000-0002-5366-5749 ; 0000-0003-2772-2575 ; 0000-0002-9793-6379 ; 0000-0001-6647-6325</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.15308$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.15308$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Song, Eun Mi</creatorcontrib><creatorcontrib>Lee, Ho‐Su</creatorcontrib><creatorcontrib>Kim, Ye‐Jee</creatorcontrib><creatorcontrib>Oh, Eun Hye</creatorcontrib><creatorcontrib>Ham, Nam Seok</creatorcontrib><creatorcontrib>Kim, Jeongseok</creatorcontrib><creatorcontrib>Hwang, Sung Wook</creatorcontrib><creatorcontrib>Park, Sang Hyoung</creatorcontrib><creatorcontrib>Yang, Dong‐Hoon</creatorcontrib><creatorcontrib>Ye, Byong Duk</creatorcontrib><creatorcontrib>Byeon, Jeong‐Sik</creatorcontrib><creatorcontrib>Myung, Seung‐Jae</creatorcontrib><creatorcontrib>Yang, Suk‐Kyun</creatorcontrib><title>Clinical outcomes and long‐term prognosis of perianal Crohn's disease in an Asian population</title><title>Journal of gastroenterology and hepatology</title><description>Background and Aim
The clinical impact of perianal Crohn's disease (CD) (pCD), a well‐known poor prognostic factor of CD, has not been fully evaluated in Asian patients. We investigated the outcomes of CD in Korean patients according to the presence of pCD at CD diagnosis.
Methods
Using 2010–2014 data from the national health insurance claims database, we evaluated the disease course of CD according to the presence of pCD at CD diagnosis. The results were verified in a hospital‐based cohort of 2923 patients.
Results
The cumulative risk of intestinal resection was lower in patients with pCD at diagnosis than in those without, in the population‐based cohort (9.1% vs 14.7% at 5 years after diagnosis, P < 0.001), but it was similar between the two groups in the hospital‐based cohort (36.8% vs 36.8% at 10 years after diagnosis, P = 0.950). Moreover, the cumulative risk of behavioral progression was not significantly different between the two groups in the hospital‐based cohort (43.4% vs 41.6% at 10 years after diagnosis, P = 0.366). On multivariable analysis, pCD at CD diagnosis was not a predictor of intestinal resection, behavioral progression, CD‐related hospital admission, or diverting surgery; however, it was an independent predictor of proctectomy (hazard ratio [HR] 3.210, P < 0.001) and anorectal cancer (HR 3.104, P = 0.047).
Conclusions
Although the presence of pCD increased the risk of proctectomy and anorectal cancer in Asian patients, the clinical impact of pCD on the overall outcomes of patients with CD may be less significant in Asian patients compared with Western patients.</description><subject>Anorectal</subject><subject>Clinical outcomes</subject><subject>Crohn's disease</subject><subject>Diagnosis</subject><subject>Intestine</subject><subject>Patients</subject><subject>Perianal fistula</subject><subject>Prognosis</subject><subject>Surgery</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10LFOwzAQBmALgUQpDLyBJQZgCPXFTp2MVQQtqBILrERO4rSuHDvYiVA3HoFn5EkwhAmJWzzcd9bdj9A5kBsINdtttjeQUJIeoAkwRiLgbH6IJiSFJMooZMfoxPsdIYQRnkzQS66VUZXQ2A59ZVvpsTA11tZsPt8_eula3Dm7MdYrj22DO-mUMIHnzm7Npce18lJ4iZUJg3jhQxd3thu06JU1p-ioEdrLs993ip7vbp_yVbR-XN7ni3VU0bBrlDCacdKQmseMl3MGHOqKNw1IzniaxjzmBEoqkqyUhNI4XAN1Ws1TKCuWSUqn6Gr8Nyz7OkjfF63yldRaGGkHX8QsYUCBsjjQiz90ZwcXTgoqoRlJIIt5UNejqpz13smm6JxqhdsXQIrvpIuQdPGTdLCz0b4pLff_w-JhuRonvgD8QH6Q</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Song, Eun Mi</creator><creator>Lee, Ho‐Su</creator><creator>Kim, Ye‐Jee</creator><creator>Oh, Eun Hye</creator><creator>Ham, Nam Seok</creator><creator>Kim, Jeongseok</creator><creator>Hwang, Sung Wook</creator><creator>Park, Sang Hyoung</creator><creator>Yang, Dong‐Hoon</creator><creator>Ye, Byong Duk</creator><creator>Byeon, Jeong‐Sik</creator><creator>Myung, Seung‐Jae</creator><creator>Yang, Suk‐Kyun</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5366-5749</orcidid><orcidid>https://orcid.org/0000-0003-2772-2575</orcidid><orcidid>https://orcid.org/0000-0002-9793-6379</orcidid><orcidid>https://orcid.org/0000-0001-6647-6325</orcidid></search><sort><creationdate>202106</creationdate><title>Clinical outcomes and long‐term prognosis of perianal Crohn's disease in an Asian population</title><author>Song, Eun Mi ; Lee, Ho‐Su ; Kim, Ye‐Jee ; Oh, Eun Hye ; Ham, Nam Seok ; Kim, Jeongseok ; Hwang, Sung Wook ; Park, Sang Hyoung ; Yang, Dong‐Hoon ; Ye, Byong Duk ; Byeon, Jeong‐Sik ; Myung, Seung‐Jae ; Yang, Suk‐Kyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3308-543970f0d7247b64171dc7ff1e74788272701b3a59be03320811d8c681bc49e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anorectal</topic><topic>Clinical outcomes</topic><topic>Crohn's disease</topic><topic>Diagnosis</topic><topic>Intestine</topic><topic>Patients</topic><topic>Perianal fistula</topic><topic>Prognosis</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Eun Mi</creatorcontrib><creatorcontrib>Lee, Ho‐Su</creatorcontrib><creatorcontrib>Kim, Ye‐Jee</creatorcontrib><creatorcontrib>Oh, Eun Hye</creatorcontrib><creatorcontrib>Ham, Nam Seok</creatorcontrib><creatorcontrib>Kim, Jeongseok</creatorcontrib><creatorcontrib>Hwang, Sung Wook</creatorcontrib><creatorcontrib>Park, Sang Hyoung</creatorcontrib><creatorcontrib>Yang, Dong‐Hoon</creatorcontrib><creatorcontrib>Ye, Byong Duk</creatorcontrib><creatorcontrib>Byeon, Jeong‐Sik</creatorcontrib><creatorcontrib>Myung, Seung‐Jae</creatorcontrib><creatorcontrib>Yang, Suk‐Kyun</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Eun Mi</au><au>Lee, Ho‐Su</au><au>Kim, Ye‐Jee</au><au>Oh, Eun Hye</au><au>Ham, Nam Seok</au><au>Kim, Jeongseok</au><au>Hwang, Sung Wook</au><au>Park, Sang Hyoung</au><au>Yang, Dong‐Hoon</au><au>Ye, Byong Duk</au><au>Byeon, Jeong‐Sik</au><au>Myung, Seung‐Jae</au><au>Yang, Suk‐Kyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical outcomes and long‐term prognosis of perianal Crohn's disease in an Asian population</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><date>2021-06</date><risdate>2021</risdate><volume>36</volume><issue>6</issue><spage>1571</spage><epage>1579</epage><pages>1571-1579</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
The clinical impact of perianal Crohn's disease (CD) (pCD), a well‐known poor prognostic factor of CD, has not been fully evaluated in Asian patients. We investigated the outcomes of CD in Korean patients according to the presence of pCD at CD diagnosis.
Methods
Using 2010–2014 data from the national health insurance claims database, we evaluated the disease course of CD according to the presence of pCD at CD diagnosis. The results were verified in a hospital‐based cohort of 2923 patients.
Results
The cumulative risk of intestinal resection was lower in patients with pCD at diagnosis than in those without, in the population‐based cohort (9.1% vs 14.7% at 5 years after diagnosis, P < 0.001), but it was similar between the two groups in the hospital‐based cohort (36.8% vs 36.8% at 10 years after diagnosis, P = 0.950). Moreover, the cumulative risk of behavioral progression was not significantly different between the two groups in the hospital‐based cohort (43.4% vs 41.6% at 10 years after diagnosis, P = 0.366). On multivariable analysis, pCD at CD diagnosis was not a predictor of intestinal resection, behavioral progression, CD‐related hospital admission, or diverting surgery; however, it was an independent predictor of proctectomy (hazard ratio [HR] 3.210, P < 0.001) and anorectal cancer (HR 3.104, P = 0.047).
Conclusions
Although the presence of pCD increased the risk of proctectomy and anorectal cancer in Asian patients, the clinical impact of pCD on the overall outcomes of patients with CD may be less significant in Asian patients compared with Western patients.</abstract><cop>Richmond</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/jgh.15308</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5366-5749</orcidid><orcidid>https://orcid.org/0000-0003-2772-2575</orcidid><orcidid>https://orcid.org/0000-0002-9793-6379</orcidid><orcidid>https://orcid.org/0000-0001-6647-6325</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0815-9319 |
| ispartof | Journal of gastroenterology and hepatology, 2021-06, Vol.36 (6), p.1571-1579 |
| issn | 0815-9319 1440-1746 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2454131342 |
| source | Access via Wiley Online Library |
| subjects | Anorectal Clinical outcomes Crohn's disease Diagnosis Intestine Patients Perianal fistula Prognosis Surgery |
| title | Clinical outcomes and long‐term prognosis of perianal Crohn's disease in an Asian population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T03%3A05%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20outcomes%20and%20long%E2%80%90term%20prognosis%20of%20perianal%20Crohn's%20disease%20in%20an%20Asian%20population&rft.jtitle=Journal%20of%20gastroenterology%20and%20hepatology&rft.au=Song,%20Eun%20Mi&rft.date=2021-06&rft.volume=36&rft.issue=6&rft.spage=1571&rft.epage=1579&rft.pages=1571-1579&rft.issn=0815-9319&rft.eissn=1440-1746&rft_id=info:doi/10.1111/jgh.15308&rft_dat=%3Cproquest_cross%3E2539051927%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2539051927&rft_id=info:pmid/&rfr_iscdi=true |