Human β‐defensin‐2 suppresses key features of asthma in murine models of allergic airways disease

Background Asthma is an airway inflammatory disease and a major health problem worldwide. Anti‐inflammatory steroids and bronchodilators are the gold‐standard therapy for asthma. However, they do not prevent the development of the disease, and critically, a subset of asthmatics are resistant to ster...

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Veröffentlicht in:	Clinical and experimental allergy 2021-01, Vol.51 (1), p.120-131
Hauptverfasser:	Pinkerton, James W., Kim, Richard Y., Koeninger, Louis, Armbruster, Nicole S., Hansbro, Nicole G., Brown, Alexandra C., Jayaraman, Ranjith, Shen, Sijie, Malek, Nisar, Cooper, Matthew A., Nordkild, Peter, Horvat, Jay C., Jensen, Benjamin A. H., Wehkamp, Jan, Hansbro, Philip M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway Resistance - drug effects Alveoli Animal models Animals Asthma Asthma - metabolism Asthma - physiopathology beta-Defensins - pharmacology Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Bronchodilators Bronchus Chlamydia Infections - metabolism Chlamydia Infections - physiopathology Chlamydia muridarum Cytokines Defensins Disease Models, Animal human β‐defensin‐2 Inflammation - metabolism Inflammation - physiopathology Inflammatory diseases Interleukin-13 - metabolism Interleukin-9 - metabolism Lung - drug effects Lung - metabolism Lung - physiopathology Lung Compliance - drug effects Methacholine Mice Ovalbumin Pyroglyphidae Respiratory Hypersensitivity - metabolism Respiratory Hypersensitivity - physiopathology Respiratory tract Respiratory tract diseases Respiratory Tract Infections - metabolism Respiratory Tract Infections - physiopathology Steroid hormones steroid resistant steroid sensitive
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