A medium-firm drug-candidate library of cryptand-like structures on T7 phage: design and selection of a strong binder for Hsp90

We designed and synthesized a medium-firm drug-candidate library of cryptand-like structures possessing a randomized peptide linker on the bacteriophage T7. From the macrocyclic library with a 10 9 diversity, we obtained a binder toward a cancer-related protein (Hsp90) with an antibody-like strong a...

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Veröffentlicht in:	Organic & biomolecular chemistry 2021-01, Vol.19 (1), p.146-15
Hauptverfasser:	Mochizuki, Kazuto, Matsukura, Lisa, Ito, Yuji, Miyashita, Naoyuki, Taki, Masumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Binding Drug development Enthalpy Hsp90 protein Libraries Phages
Online-Zugang:	Volltext
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