SIRT1-mediated deacetylation of NF-κB inhibits the MLCK/MLC2 pathway and the expression of ET-1, thus alleviating the development of coronary artery spasm

Coronary artery spasm (CAS) is an intense vasoconstriction of coronary arteries that causes total or subtotal vessel occlusion. The cardioprotective effect of sirtuin-1 (SIRT1) has been extensively highlighted in coronary artery diseases. The aims within this study include the investigation of the m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2021-01, Vol.320 (1), p.H458-H468
Hauptverfasser:	Wu, Bo-Wen, Wu, Mi-Shan, Liu, Yu, Lu, Meng, Guo, Jin-Dong, Meng, Yun-Hui, Zhou, Yu-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animal models Animals Arteries Blood vessels Calponin Cardiac Myosins - metabolism Cell Proliferation Cell Shape Cells, Cultured Collagen Coronary artery Coronary Vasospasm - enzymology Coronary Vasospasm - genetics Coronary Vasospasm - physiopathology Coronary Vasospasm - prevention & control Coronary vessels Coronary Vessels - enzymology Coronary Vessels - physiopathology Deacetylation Depletion Disease Models, Animal Ectopic expression Endothelin 1 Endothelin-1 - metabolism Kinases Male Muscle contraction Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - physiopathology Muscles Myosin Myosin Light Chains - metabolism Myosin-light-chain kinase Myosin-Light-Chain Kinase - metabolism NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Occlusion Polymerase chain reaction Rats Rats, Nude Rats, Sprague-Dawley Reverse transcription Signal Transduction SIRT1 protein Sirtuin 1 - genetics Sirtuin 1 - metabolism Smooth muscle Vasoconstriction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!