Prognostic Molecular and Biological Characteristics of Phyllodes Tumors of the Breast
Prognosis for some histological variants of a rare breast disease, phyllodes tumors, is evaluated. The prognostic potential of some molecular biological factors significantly correlating with breast cancer prognosis is evaluated on a unique clinical material (244 cases with benign, intermediate, and...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2020-10, Vol.169 (6), p.806-810 |
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| creator | Vorotnikov, I. K. Vysotskaya, I. V. Denchik, D. A. Letyagin, V. P. Davydov, M. M. Kirsanov, V. Yu Kim, E. A. Buseva, V. S. |
| description | Prognosis for some histological variants of a rare breast disease, phyllodes tumors, is evaluated. The prognostic potential of some molecular biological factors significantly correlating with breast cancer prognosis is evaluated on a unique clinical material (244 cases with benign, intermediate, and malignant phyllodes tumors). The development of benign phyllodes tumor relapse directly correlated with the number of G0/1-phase cells and inversely correlated with the number of cells in the G2+M and S phases. The level of steroid hormone receptors in phyllodes tumors cannot serve as a prognostic marker predicting the disease course. The presence of somatic mutations of
TP53
gene and loss of heterozygosity of specific intragenic loci in the tumor correlate with the development of disease relapse (
p |
| doi_str_mv | 10.1007/s10517-020-04985-5 |
| format | Article |
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TP53
gene and loss of heterozygosity of specific intragenic loci in the tumor correlate with the development of disease relapse (
p
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TP53
gene and loss of heterozygosity of specific intragenic loci in the tumor correlate with the development of disease relapse (
p
<0.05).</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Cell Biology</subject><subject>Development and progression</subject><subject>Genetic aspects</subject><subject>Heterozygosity</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Loss of heterozygosity</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>p53 Protein</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Steroid hormone receptors</subject><subject>Steroid hormones</subject><subject>Tumor proteins</subject><subject>Tumors</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNksFrHCEYxaU00G3Sf6CngULpZVJ1dXSPydI2gYTkkJzlG-ebHYM7puoc8t_HyRayKWUpHsTH771P5RHymdFTRqn6nhiVTNWU05qKlZa1fEcWTKplrTln78mCFqoWWusP5GNKD_ORNmxB7m9j2IwhZWer6-DRTh5iBWNXnbvgw8ZZ8NV6gAg2Y3Qzl6rQV7fDk_ehw1TdTdsQX7Q8YHUeEVI-IUc9-ISf_uzH5P7nj7v1RX118-tyfXZVWyl0rkFYLgGxk13XI0XaQoei5Y0USlKAloqmVVZ0CEoXmfeqlbqItEXdq9XymHzb5T7G8HvClM3WJYvew4hhSoYLKRhtZNMU9Mtf6EOY4lhuVyjFZMnlq1dqAx6NG_uQy8vnUHPWaLYSDZf6MCXFknLJZ-r0H1RZHW6dDSP2ruhvYv_PsDfh655hQPB5SMFP2YUxvU0-DO4l8h1oY0gpYm8eo9tCfDKMmrlpZtc0U5pmXppmZDEtd6ZU4HGD8fVrD7ieAaEG0cc</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Vorotnikov, I. 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K.</creatorcontrib><creatorcontrib>Vysotskaya, I. V.</creatorcontrib><creatorcontrib>Denchik, D. A.</creatorcontrib><creatorcontrib>Letyagin, V. P.</creatorcontrib><creatorcontrib>Davydov, M. M.</creatorcontrib><creatorcontrib>Kirsanov, V. Yu</creatorcontrib><creatorcontrib>Kim, E. A.</creatorcontrib><creatorcontrib>Buseva, V. 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K.</au><au>Vysotskaya, I. V.</au><au>Denchik, D. A.</au><au>Letyagin, V. P.</au><au>Davydov, M. M.</au><au>Kirsanov, V. Yu</au><au>Kim, E. A.</au><au>Buseva, V. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Molecular and Biological Characteristics of Phyllodes Tumors of the Breast</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><date>2020-10-01</date><risdate>2020</risdate><volume>169</volume><issue>6</issue><spage>806</spage><epage>810</epage><pages>806-810</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>Prognosis for some histological variants of a rare breast disease, phyllodes tumors, is evaluated. The prognostic potential of some molecular biological factors significantly correlating with breast cancer prognosis is evaluated on a unique clinical material (244 cases with benign, intermediate, and malignant phyllodes tumors). The development of benign phyllodes tumor relapse directly correlated with the number of G0/1-phase cells and inversely correlated with the number of cells in the G2+M and S phases. The level of steroid hormone receptors in phyllodes tumors cannot serve as a prognostic marker predicting the disease course. The presence of somatic mutations of
TP53
gene and loss of heterozygosity of specific intragenic loci in the tumor correlate with the development of disease relapse (
p
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| subjects | Biomedical and Life Sciences Biomedicine Breast cancer Cell Biology Development and progression Genetic aspects Heterozygosity Internal Medicine Laboratory Medicine Loss of heterozygosity Medical prognosis Medical research Medicine, Experimental p53 Protein Pathology Prognosis Steroid hormone receptors Steroid hormones Tumor proteins Tumors |
| title | Prognostic Molecular and Biological Characteristics of Phyllodes Tumors of the Breast |
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