Associations between the size and location of myocardial infarction and cerebral infarction
Myocardial infarction (MI) is a known cause of cerebral infarction. We assessed whether the size and location of MI is associated with the risk of cerebral infarction. We performed a cross-sectional study of adults who underwent both brain MRI and delayed-enhancement cardiac MRI (DE-CMR) within 365 ...
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| Veröffentlicht in: | Journal of the neurological sciences 2020-12, Vol.419, p.117182-117182, Article 117182 |
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| container_title | Journal of the neurological sciences |
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| creator | Merkler, Alexander E. Alakbarli, Javid Barbar, Tarek Baradaran, Hediyeh Adejumo, Oluwayemisi Navi, Babak B. Kamel, Hooman Kim, Jiwon Okin, Peter M. Gupta, Ajay Weinsaft, Jonathan W. |
| description | Myocardial infarction (MI) is a known cause of cerebral infarction. We assessed whether the size and location of MI is associated with the risk of cerebral infarction.
We performed a cross-sectional study of adults who underwent both brain MRI and delayed-enhancement cardiac MRI (DE-CMR) within 365 days of each other at Weill Cornell Medicine between 2014 and 2017 and had evidence of MI on DE-CMR. We used multiple logistic regression to evaluate associations between MI size and any cerebral infarction, apical MI location and any cerebral infarction, and MI size/location and cortical versus subcortical cerebral infarction. Models were adjusted for demographics, and the total number of vascular risk factors. Among 234 patients who underwent both DE-CMR and brain MRI within 365 days, 76 had evidence for MI on DE-CMR. Among these 76 patients, 51 (67.1%) had evidence of cerebral infarction. The size of MI (global MI burden) was not associated with any cerebral infarction (OR per 5% increase in MI size, 1.12; 95% CI, 0.85–1.47), but was associated with cortical cerebral infarction (OR per 5% increase in MI size, 1.30; 95% CI, 1.00.-1.68). Similarly, apical MI location was not associated with any cerebral infarction (OR 2.63, 95% CI, 0.78–8.87), but was associated with cortical cerebral infarction (OR, 3.67; 95% CI, 1.19–11.33).
Among patients with MI on cardiac MRI, both size and apical location of MI were associated with cortical cerebral infarction. Our results may help stratify cardioembolic risk and inform antithrombotic treatment algorithms among patients with MI.
•There is no association between size of myocardial infarction or apical myocardial infarction and any cerebral infarction.•The size of myocardial infarction is associated with cortical cerebral infarction•Apical location of myocardial infarction is associated with cortical cerebral infarction |
| doi_str_mv | 10.1016/j.jns.2020.117182 |
| format | Article |
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We performed a cross-sectional study of adults who underwent both brain MRI and delayed-enhancement cardiac MRI (DE-CMR) within 365 days of each other at Weill Cornell Medicine between 2014 and 2017 and had evidence of MI on DE-CMR. We used multiple logistic regression to evaluate associations between MI size and any cerebral infarction, apical MI location and any cerebral infarction, and MI size/location and cortical versus subcortical cerebral infarction. Models were adjusted for demographics, and the total number of vascular risk factors. Among 234 patients who underwent both DE-CMR and brain MRI within 365 days, 76 had evidence for MI on DE-CMR. Among these 76 patients, 51 (67.1%) had evidence of cerebral infarction. The size of MI (global MI burden) was not associated with any cerebral infarction (OR per 5% increase in MI size, 1.12; 95% CI, 0.85–1.47), but was associated with cortical cerebral infarction (OR per 5% increase in MI size, 1.30; 95% CI, 1.00.-1.68). Similarly, apical MI location was not associated with any cerebral infarction (OR 2.63, 95% CI, 0.78–8.87), but was associated with cortical cerebral infarction (OR, 3.67; 95% CI, 1.19–11.33).
Among patients with MI on cardiac MRI, both size and apical location of MI were associated with cortical cerebral infarction. Our results may help stratify cardioembolic risk and inform antithrombotic treatment algorithms among patients with MI.
•There is no association between size of myocardial infarction or apical myocardial infarction and any cerebral infarction.•The size of myocardial infarction is associated with cortical cerebral infarction•Apical location of myocardial infarction is associated with cortical cerebral infarction</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2020.117182</identifier><identifier>PMID: 33099172</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Brain MRI ; Cardiac MRI ; Cerebral infarction ; Cerebral Infarction - complications ; Cerebral Infarction - diagnostic imaging ; Cerebral Infarction - epidemiology ; Cross-Sectional Studies ; Humans ; Magnetic Resonance Imaging ; Myocardial infarction ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - epidemiology ; Predictive Value of Tests</subject><ispartof>Journal of the neurological sciences, 2020-12, Vol.419, p.117182-117182, Article 117182</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c283t-5b01869f7bb2d04952d13c716b07f975f95c30abf3a024e583ab54c686da38ff3</citedby><cites>FETCH-LOGICAL-c283t-5b01869f7bb2d04952d13c716b07f975f95c30abf3a024e583ab54c686da38ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jns.2020.117182$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33099172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Merkler, Alexander E.</creatorcontrib><creatorcontrib>Alakbarli, Javid</creatorcontrib><creatorcontrib>Barbar, Tarek</creatorcontrib><creatorcontrib>Baradaran, Hediyeh</creatorcontrib><creatorcontrib>Adejumo, Oluwayemisi</creatorcontrib><creatorcontrib>Navi, Babak B.</creatorcontrib><creatorcontrib>Kamel, Hooman</creatorcontrib><creatorcontrib>Kim, Jiwon</creatorcontrib><creatorcontrib>Okin, Peter M.</creatorcontrib><creatorcontrib>Gupta, Ajay</creatorcontrib><creatorcontrib>Weinsaft, Jonathan W.</creatorcontrib><title>Associations between the size and location of myocardial infarction and cerebral infarction</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Myocardial infarction (MI) is a known cause of cerebral infarction. We assessed whether the size and location of MI is associated with the risk of cerebral infarction.
We performed a cross-sectional study of adults who underwent both brain MRI and delayed-enhancement cardiac MRI (DE-CMR) within 365 days of each other at Weill Cornell Medicine between 2014 and 2017 and had evidence of MI on DE-CMR. We used multiple logistic regression to evaluate associations between MI size and any cerebral infarction, apical MI location and any cerebral infarction, and MI size/location and cortical versus subcortical cerebral infarction. Models were adjusted for demographics, and the total number of vascular risk factors. Among 234 patients who underwent both DE-CMR and brain MRI within 365 days, 76 had evidence for MI on DE-CMR. Among these 76 patients, 51 (67.1%) had evidence of cerebral infarction. The size of MI (global MI burden) was not associated with any cerebral infarction (OR per 5% increase in MI size, 1.12; 95% CI, 0.85–1.47), but was associated with cortical cerebral infarction (OR per 5% increase in MI size, 1.30; 95% CI, 1.00.-1.68). Similarly, apical MI location was not associated with any cerebral infarction (OR 2.63, 95% CI, 0.78–8.87), but was associated with cortical cerebral infarction (OR, 3.67; 95% CI, 1.19–11.33).
Among patients with MI on cardiac MRI, both size and apical location of MI were associated with cortical cerebral infarction. Our results may help stratify cardioembolic risk and inform antithrombotic treatment algorithms among patients with MI.
•There is no association between size of myocardial infarction or apical myocardial infarction and any cerebral infarction.•The size of myocardial infarction is associated with cortical cerebral infarction•Apical location of myocardial infarction is associated with cortical cerebral infarction</description><subject>Adult</subject><subject>Brain MRI</subject><subject>Cardiac MRI</subject><subject>Cerebral infarction</subject><subject>Cerebral Infarction - complications</subject><subject>Cerebral Infarction - diagnostic imaging</subject><subject>Cerebral Infarction - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Predictive Value of Tests</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlZ_gBfZo5etk2Szm8VTKX5BwYuC4CEk2QmmbHdrslXqr3f7oeDF0zAzz7wwDyHnFMYUaH41H8-bOGbA-p4WVLIDMqSykKmQkh-SIQBjqaDwMiAnMc4BIJeyPCYDzqEsacGG5HUSY2u97nzbxMRg94nYJN0bJtF_YaKbKqlbu10nrUsW674Jldd14hung90uNpTFgCb8mZ-SI6friGf7OiLPtzdP0_t09nj3MJ3MUssk71JhgMq8dIUxrIKsFKyi3BY0N1C4shCuFJaDNo5rYBkKybURmc1lXmkuneMjcrnLXYb2fYWxUwsfLda1brBdRcUykVEQkOU9SneoDW2MAZ1aBr_QYa0oqI1TNVe9U7VxqnZO-5uLffzKLLD6vfiR2APXOwD7Jz88BhWtx8Zi5QPaTlWt_yf-GzSYh9E</recordid><startdate>20201215</startdate><enddate>20201215</enddate><creator>Merkler, Alexander E.</creator><creator>Alakbarli, Javid</creator><creator>Barbar, Tarek</creator><creator>Baradaran, Hediyeh</creator><creator>Adejumo, Oluwayemisi</creator><creator>Navi, Babak B.</creator><creator>Kamel, Hooman</creator><creator>Kim, Jiwon</creator><creator>Okin, Peter M.</creator><creator>Gupta, Ajay</creator><creator>Weinsaft, Jonathan W.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20201215</creationdate><title>Associations between the size and location of myocardial infarction and cerebral infarction</title><author>Merkler, Alexander E. ; Alakbarli, Javid ; Barbar, Tarek ; Baradaran, Hediyeh ; Adejumo, Oluwayemisi ; Navi, Babak B. ; Kamel, Hooman ; Kim, Jiwon ; Okin, Peter M. ; Gupta, Ajay ; Weinsaft, Jonathan W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c283t-5b01869f7bb2d04952d13c716b07f975f95c30abf3a024e583ab54c686da38ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Brain MRI</topic><topic>Cardiac MRI</topic><topic>Cerebral infarction</topic><topic>Cerebral Infarction - complications</topic><topic>Cerebral Infarction - diagnostic imaging</topic><topic>Cerebral Infarction - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Predictive Value of Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Merkler, Alexander E.</creatorcontrib><creatorcontrib>Alakbarli, Javid</creatorcontrib><creatorcontrib>Barbar, Tarek</creatorcontrib><creatorcontrib>Baradaran, Hediyeh</creatorcontrib><creatorcontrib>Adejumo, Oluwayemisi</creatorcontrib><creatorcontrib>Navi, Babak B.</creatorcontrib><creatorcontrib>Kamel, Hooman</creatorcontrib><creatorcontrib>Kim, Jiwon</creatorcontrib><creatorcontrib>Okin, Peter M.</creatorcontrib><creatorcontrib>Gupta, Ajay</creatorcontrib><creatorcontrib>Weinsaft, Jonathan W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Merkler, Alexander E.</au><au>Alakbarli, Javid</au><au>Barbar, Tarek</au><au>Baradaran, Hediyeh</au><au>Adejumo, Oluwayemisi</au><au>Navi, Babak B.</au><au>Kamel, Hooman</au><au>Kim, Jiwon</au><au>Okin, Peter M.</au><au>Gupta, Ajay</au><au>Weinsaft, Jonathan W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between the size and location of myocardial infarction and cerebral infarction</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2020-12-15</date><risdate>2020</risdate><volume>419</volume><spage>117182</spage><epage>117182</epage><pages>117182-117182</pages><artnum>117182</artnum><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract>Myocardial infarction (MI) is a known cause of cerebral infarction. We assessed whether the size and location of MI is associated with the risk of cerebral infarction.
We performed a cross-sectional study of adults who underwent both brain MRI and delayed-enhancement cardiac MRI (DE-CMR) within 365 days of each other at Weill Cornell Medicine between 2014 and 2017 and had evidence of MI on DE-CMR. We used multiple logistic regression to evaluate associations between MI size and any cerebral infarction, apical MI location and any cerebral infarction, and MI size/location and cortical versus subcortical cerebral infarction. Models were adjusted for demographics, and the total number of vascular risk factors. Among 234 patients who underwent both DE-CMR and brain MRI within 365 days, 76 had evidence for MI on DE-CMR. Among these 76 patients, 51 (67.1%) had evidence of cerebral infarction. The size of MI (global MI burden) was not associated with any cerebral infarction (OR per 5% increase in MI size, 1.12; 95% CI, 0.85–1.47), but was associated with cortical cerebral infarction (OR per 5% increase in MI size, 1.30; 95% CI, 1.00.-1.68). Similarly, apical MI location was not associated with any cerebral infarction (OR 2.63, 95% CI, 0.78–8.87), but was associated with cortical cerebral infarction (OR, 3.67; 95% CI, 1.19–11.33).
Among patients with MI on cardiac MRI, both size and apical location of MI were associated with cortical cerebral infarction. Our results may help stratify cardioembolic risk and inform antithrombotic treatment algorithms among patients with MI.
•There is no association between size of myocardial infarction or apical myocardial infarction and any cerebral infarction.•The size of myocardial infarction is associated with cortical cerebral infarction•Apical location of myocardial infarction is associated with cortical cerebral infarction</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33099172</pmid><doi>10.1016/j.jns.2020.117182</doi><tpages>1</tpages></addata></record> |
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| subjects | Adult Brain MRI Cardiac MRI Cerebral infarction Cerebral Infarction - complications Cerebral Infarction - diagnostic imaging Cerebral Infarction - epidemiology Cross-Sectional Studies Humans Magnetic Resonance Imaging Myocardial infarction Myocardial Infarction - diagnostic imaging Myocardial Infarction - epidemiology Predictive Value of Tests |
| title | Associations between the size and location of myocardial infarction and cerebral infarction |
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