Blocking VCAM-1 inhibits pancreatic tumour progression and cancer-associated thrombosis/thromboembolism

ObjectivePancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer. Cancer-associated thrombosis/thromboembolism (CAT), frequently observed in PDAC, is known as a poor prognostic factor. Here, we investigated the underlying mechanisms between PDAC and CAT, and performed a trial of therapeutic...

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Veröffentlicht in:	Gut 2021-09, Vol.70 (9), p.1713-1723
Hauptverfasser:	Sano, Makoto, Takahashi, Ryota, Ijichi, Hideaki, Ishigaki, Kazunaga, Yamada, Tomoharu, Miyabayashi, Koji, Kimura, Gen, Mizuno, Suguru, Kato, Hiroyuki, Fujiwara, Hiroaki, Nakatsuka, Takuma, Tanaka, Yasuo, Kim, Jinsuk, Masugi, Yohei, Morishita, Yasuyuki, Tanaka, Mariko, Ushiku, Tetsuo, Nakai, Yousuke, Tateishi, Keisuke, Ishii, Yukimoto, Isayama, Hiroyuki, Moses, Harold L, Koike, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Angiogenesis Animals Atrial natriuretic peptide Autopsy Blood clots Carcinoma, Pancreatic Ductal - complications Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - therapy Cell adhesion & migration Cell adhesion molecules Chemotherapy Cytokines Endothelium Enzyme-linked immunosorbent assay Female Genetic engineering Heart Humans Immunohistochemistry Leukocytes (neutrophilic) Macrophages Male Medical prognosis Metastases Mice Mice, Knockout Pancreas Pancreatic cancer Pancreatic Neoplasms - complications Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Peptides Plasma Pulmonary arteries Thromboembolism Thrombosis Thrombosis - etiology Thrombosis - prevention & control Tumor Microenvironment Tumor necrosis factor-TNF Tumors Vascular cell adhesion molecule 1 Vascular Cell Adhesion Molecule-1 - metabolism
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