Investigating expression pattern of eight immune‐related genes in pemphigus patients compared with the healthy controls and after rituximab therapy: Potential roles of CTLA4 and FCGR3A genes expression in outcomes of rituximab therapy
Pemphigus is a rare group of autoimmune diseases, which its exact molecular pathogenesis and therapeutic biomarkers remained unknown. In this regard the expressions of eight immune‐related genes was evalualted in pemphigus patients. Forty‐six pemphigus patients, either new case or on minimal therapy...
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| Veröffentlicht in: | Dermatologic therapy 2020-11, Vol.33 (6), p.e14380-n/a |
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| creator | Tavakolpour, Soheil Mahmoudi, Hamidreza Karami, Fatemeh Elikaei Behjati, Somayeh Balighi, Kamran Abbasi, Maryam Salehi Farid, Ali Masoudi, Jamileh Balali, Mansour Daneshpazhooh, Maryam Modarressi, Mohammad Hossein |
| description | Pemphigus is a rare group of autoimmune diseases, which its exact molecular pathogenesis and therapeutic biomarkers remained unknown. In this regard the expressions of eight immune‐related genes was evalualted in pemphigus patients. Forty‐six pemphigus patients, either new case or on minimal therapy, were recruited. The expressions of IL22, IL9, IL21, EBI3, TNFSF13B, FCGR3A, CTLA4, and PDCD1 genes were analyzed at baseline, compared with 32 healthy controls, and their changes were monitored 3 months after rituximab (RTX) therapy through Reverse Transcriptase Real‐time PCR (RT‐Real‐time PCR). Except of IL21, which was similar in both groups, expressions of other genes were significantly lower in patients compared with the controls (P‐value |
| doi_str_mv | 10.1111/dth.14380 |
| format | Article |
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In this regard the expressions of eight immune‐related genes was evalualted in pemphigus patients. Forty‐six pemphigus patients, either new case or on minimal therapy, were recruited. The expressions of IL22, IL9, IL21, EBI3, TNFSF13B, FCGR3A, CTLA4, and PDCD1 genes were analyzed at baseline, compared with 32 healthy controls, and their changes were monitored 3 months after rituximab (RTX) therapy through Reverse Transcriptase Real‐time PCR (RT‐Real‐time PCR). Except of IL21, which was similar in both groups, expressions of other genes were significantly lower in patients compared with the controls (P‐value <.05). PDCD1, EBI3, IL21, and IL22 genes were significantly overexpressed three months following RTX administration (P‐value <.05). Higher prednisolone dosage and PDAI‐score were positively correlated with CTLA4 and FCGR3A expressions after 3 months, respectively (P‐value = .019 and .048, respectively). Anti‐desmoglein 1 (Dsg 1) titer and its positivity at baseline were associated with TNFSF13B expression, FCGR3A expressions, and the PDAI‐score. Our results suggest the possible involvement of some gene expressions in pemphigus immunopathogenesis, which could be affected by RTX therapy and also might be used as prognostic biomarkers.</description><identifier>ISSN: 1396-0296</identifier><identifier>EISSN: 1529-8019</identifier><identifier>DOI: 10.1111/dth.14380</identifier><identifier>PMID: 33090639</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>CTLA-4 Antigen - genetics ; cytokines ; Gene Expression ; Humans ; pemphigus ; Pemphigus - diagnosis ; Pemphigus - drug therapy ; Pemphigus - genetics ; Prednisolone ; Receptors, IgG - genetics ; rituximab ; Rituximab - therapeutic use ; T‐cell</subject><ispartof>Dermatologic therapy, 2020-11, Vol.33 (6), p.e14380-n/a</ispartof><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3600-91c146999b4dac156b4c1c9d21f3ccf3b46cb3ae6fcde88f60d85ced51e5138f3</citedby><cites>FETCH-LOGICAL-c3600-91c146999b4dac156b4c1c9d21f3ccf3b46cb3ae6fcde88f60d85ced51e5138f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdth.14380$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdth.14380$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33090639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tavakolpour, Soheil</creatorcontrib><creatorcontrib>Mahmoudi, Hamidreza</creatorcontrib><creatorcontrib>Karami, Fatemeh</creatorcontrib><creatorcontrib>Elikaei Behjati, Somayeh</creatorcontrib><creatorcontrib>Balighi, Kamran</creatorcontrib><creatorcontrib>Abbasi, Maryam</creatorcontrib><creatorcontrib>Salehi Farid, Ali</creatorcontrib><creatorcontrib>Masoudi, Jamileh</creatorcontrib><creatorcontrib>Balali, Mansour</creatorcontrib><creatorcontrib>Daneshpazhooh, Maryam</creatorcontrib><creatorcontrib>Modarressi, Mohammad Hossein</creatorcontrib><title>Investigating expression pattern of eight immune‐related genes in pemphigus patients compared with the healthy controls and after rituximab therapy: Potential roles of CTLA4 and FCGR3A genes expression in outcomes of rituximab therapy</title><title>Dermatologic therapy</title><addtitle>Dermatol Ther</addtitle><description>Pemphigus is a rare group of autoimmune diseases, which its exact molecular pathogenesis and therapeutic biomarkers remained unknown. In this regard the expressions of eight immune‐related genes was evalualted in pemphigus patients. Forty‐six pemphigus patients, either new case or on minimal therapy, were recruited. The expressions of IL22, IL9, IL21, EBI3, TNFSF13B, FCGR3A, CTLA4, and PDCD1 genes were analyzed at baseline, compared with 32 healthy controls, and their changes were monitored 3 months after rituximab (RTX) therapy through Reverse Transcriptase Real‐time PCR (RT‐Real‐time PCR). Except of IL21, which was similar in both groups, expressions of other genes were significantly lower in patients compared with the controls (P‐value <.05). PDCD1, EBI3, IL21, and IL22 genes were significantly overexpressed three months following RTX administration (P‐value <.05). Higher prednisolone dosage and PDAI‐score were positively correlated with CTLA4 and FCGR3A expressions after 3 months, respectively (P‐value = .019 and .048, respectively). Anti‐desmoglein 1 (Dsg 1) titer and its positivity at baseline were associated with TNFSF13B expression, FCGR3A expressions, and the PDAI‐score. Our results suggest the possible involvement of some gene expressions in pemphigus immunopathogenesis, which could be affected by RTX therapy and also might be used as prognostic biomarkers.</description><subject>CTLA-4 Antigen - genetics</subject><subject>cytokines</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>pemphigus</subject><subject>Pemphigus - diagnosis</subject><subject>Pemphigus - drug therapy</subject><subject>Pemphigus - genetics</subject><subject>Prednisolone</subject><subject>Receptors, IgG - genetics</subject><subject>rituximab</subject><subject>Rituximab - therapeutic use</subject><subject>T‐cell</subject><issn>1396-0296</issn><issn>1529-8019</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhSNERUthwQsgL2GR1o4TK2Y3GuiPNFIRGtaRY18nRokdbKft7HgEnpE1D1FPM0VICG9s6X73nCOfLHtD8BlJ51zF_oyUtMbPshNSFTyvMeHP05tyluOCs-PsZQjfMCYFp-RFdkwp5phRfpL9vra3EKLpRDS2Q3A_eQjBOIsmESN4i5xGYLo-IjOOs4VfP356GEQEhTqwEJBJKIxTb7o57JcM2BiQdOMkfILuTOxR7AH1IIbY79LERu-GgIRVSOjkgbyJ870ZRbsHvZh2H9BnF5OOEQNKbHJJKdbbzap83LpYX36hq4P_X5FTFDfHZL0s_CP7KjvSYgjw-nCfZl8vPm3XV_nm5vJ6vdrkkjKMc04kKRnnvC2VkKRibSmJ5KogmkqpaVsy2VIBTEsFda0ZVnUlQVUEKkJrTU-zd4vu5N33OX1vM5ogYRiEBTeHpigrympec5bQ9wsqvQvBg24mnyL7XUNwsy-3SeU2j-Um9u1Bdm5HUH_IpzYTcL4Ad2aA3f-Vmo_bq0XyAXSltoc</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Tavakolpour, Soheil</creator><creator>Mahmoudi, Hamidreza</creator><creator>Karami, Fatemeh</creator><creator>Elikaei Behjati, Somayeh</creator><creator>Balighi, Kamran</creator><creator>Abbasi, Maryam</creator><creator>Salehi Farid, Ali</creator><creator>Masoudi, Jamileh</creator><creator>Balali, Mansour</creator><creator>Daneshpazhooh, Maryam</creator><creator>Modarressi, Mohammad Hossein</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202011</creationdate><title>Investigating expression pattern of eight immune‐related genes in pemphigus patients compared with the healthy controls and after rituximab therapy: Potential roles of CTLA4 and FCGR3A genes expression in outcomes of rituximab therapy</title><author>Tavakolpour, Soheil ; Mahmoudi, Hamidreza ; Karami, Fatemeh ; Elikaei Behjati, Somayeh ; Balighi, Kamran ; Abbasi, Maryam ; Salehi Farid, Ali ; Masoudi, Jamileh ; Balali, Mansour ; Daneshpazhooh, Maryam ; Modarressi, Mohammad Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3600-91c146999b4dac156b4c1c9d21f3ccf3b46cb3ae6fcde88f60d85ced51e5138f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>CTLA-4 Antigen - genetics</topic><topic>cytokines</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>pemphigus</topic><topic>Pemphigus - diagnosis</topic><topic>Pemphigus - drug therapy</topic><topic>Pemphigus - genetics</topic><topic>Prednisolone</topic><topic>Receptors, IgG - genetics</topic><topic>rituximab</topic><topic>Rituximab - therapeutic use</topic><topic>T‐cell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tavakolpour, Soheil</creatorcontrib><creatorcontrib>Mahmoudi, Hamidreza</creatorcontrib><creatorcontrib>Karami, Fatemeh</creatorcontrib><creatorcontrib>Elikaei Behjati, Somayeh</creatorcontrib><creatorcontrib>Balighi, Kamran</creatorcontrib><creatorcontrib>Abbasi, Maryam</creatorcontrib><creatorcontrib>Salehi Farid, Ali</creatorcontrib><creatorcontrib>Masoudi, Jamileh</creatorcontrib><creatorcontrib>Balali, Mansour</creatorcontrib><creatorcontrib>Daneshpazhooh, Maryam</creatorcontrib><creatorcontrib>Modarressi, Mohammad Hossein</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatologic therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tavakolpour, Soheil</au><au>Mahmoudi, Hamidreza</au><au>Karami, Fatemeh</au><au>Elikaei Behjati, Somayeh</au><au>Balighi, Kamran</au><au>Abbasi, Maryam</au><au>Salehi Farid, Ali</au><au>Masoudi, Jamileh</au><au>Balali, Mansour</au><au>Daneshpazhooh, Maryam</au><au>Modarressi, Mohammad Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigating expression pattern of eight immune‐related genes in pemphigus patients compared with the healthy controls and after rituximab therapy: Potential roles of CTLA4 and FCGR3A genes expression in outcomes of rituximab therapy</atitle><jtitle>Dermatologic therapy</jtitle><addtitle>Dermatol Ther</addtitle><date>2020-11</date><risdate>2020</risdate><volume>33</volume><issue>6</issue><spage>e14380</spage><epage>n/a</epage><pages>e14380-n/a</pages><issn>1396-0296</issn><eissn>1529-8019</eissn><abstract>Pemphigus is a rare group of autoimmune diseases, which its exact molecular pathogenesis and therapeutic biomarkers remained unknown. In this regard the expressions of eight immune‐related genes was evalualted in pemphigus patients. Forty‐six pemphigus patients, either new case or on minimal therapy, were recruited. The expressions of IL22, IL9, IL21, EBI3, TNFSF13B, FCGR3A, CTLA4, and PDCD1 genes were analyzed at baseline, compared with 32 healthy controls, and their changes were monitored 3 months after rituximab (RTX) therapy through Reverse Transcriptase Real‐time PCR (RT‐Real‐time PCR). Except of IL21, which was similar in both groups, expressions of other genes were significantly lower in patients compared with the controls (P‐value <.05). PDCD1, EBI3, IL21, and IL22 genes were significantly overexpressed three months following RTX administration (P‐value <.05). Higher prednisolone dosage and PDAI‐score were positively correlated with CTLA4 and FCGR3A expressions after 3 months, respectively (P‐value = .019 and .048, respectively). Anti‐desmoglein 1 (Dsg 1) titer and its positivity at baseline were associated with TNFSF13B expression, FCGR3A expressions, and the PDAI‐score. Our results suggest the possible involvement of some gene expressions in pemphigus immunopathogenesis, which could be affected by RTX therapy and also might be used as prognostic biomarkers.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33090639</pmid><doi>10.1111/dth.14380</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | CTLA-4 Antigen - genetics cytokines Gene Expression Humans pemphigus Pemphigus - diagnosis Pemphigus - drug therapy Pemphigus - genetics Prednisolone Receptors, IgG - genetics rituximab Rituximab - therapeutic use T‐cell |
| title | Investigating expression pattern of eight immune‐related genes in pemphigus patients compared with the healthy controls and after rituximab therapy: Potential roles of CTLA4 and FCGR3A genes expression in outcomes of rituximab therapy |
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