Knockdown of Bcl-2-Associated Athanogene-3 Can Enhance the Efficacy of BGJ398 via Suppressing Migration and Inducing Apoptosis in Gastric Cancer

Background Gastric cancer (GC) is one of the most common malignancies of the digestive tract worldwide, and cancer cell resistance against anticancer drugs remains a major challenge for GC treatment. Nvp-BGJ398 (BGJ398) is considered as a common drug for cancer treatment; however, Bcl-2-associated a...

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Veröffentlicht in:	Digestive diseases and sciences 2021-09, Vol.66 (9), p.3036-3044
Hauptverfasser:	Li, Ke, Deng, Xiang, Feng, Guangjing, Chen, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis Regulatory Proteins - genetics Biochemistry Cancer Care and treatment Cell Line, Tumor Cell Movement Cell Survival Drug Discovery Drug resistance Drug Resistance, Neoplasm - genetics Drug therapy Gastric cancer Gastroenterology Gene Expression Regulation, Neoplastic - drug effects Health aspects Heat Shock Transcription Factors - genetics Hepatology Humans Medicine Medicine & Public Health Mice Mice, Knockout Oncology Original Article Phenylurea Compounds - pharmacology Pyrimidines - pharmacology Stomach cancer Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Transplant Surgery Xenograft Model Antitumor Assays - methods
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