Active targeting of gold nanoparticles as cancer therapeutics

Active targeting of gold nanoparticles as cancer therapeutics

Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug carriers. The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers, wit...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical Society reviews 2020-12, Vol.49 (23), p.8774-8789
Hauptverfasser: Goddard, Zoë Rachael, Marín, María J., Russell, David A., Searcey, Mark
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Cancer
Carbohydrates
Drug carriers
Gold
Ligands
Nanoparticles
Peptides
Toxicity
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 8789
container_issue 23
container_start_page 8774
container_title Chemical Society reviews
container_volume 49
creator Goddard, Zoë Rachael
Marín, María J.
Russell, David A.
Searcey, Mark
description Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug carriers. The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers, with antibodies, proteins, peptides, aptamers, carbohydrates and small molecules all exploited. Here, we review the recent advances in targeted-AuNPs for the treatment of cancer, with a particular focus on these classes of targeting ligands. We highlight the benefits and potential drawbacks of each ligand class and propose directions in which the field could grow.
doi_str_mv 10.1039/d0cs01121e
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2453683420</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2453683420</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-1e08dfd15f3959020bb8983b5697d8d8284720ab73af30e26c8db4a6fb0963d63</originalsourceid><addsrcrecordid>eNpd0MtKxDAUBuAgCo6jG58g4EaE6smlabJwMYzjBQZcqOuS5jJ26DQ1SQXf3uq4cnUOnI-fw4_QOYFrAkzdWDAJCKHEHaAZ4QIKXnF-iGbAQBQAhB6jk5S200YqQWfodmFy--lw1nHjcttvcPB4EzqLe92HQcfcms4lrBM2ujcu4vzuoh7cOB3SKTryukvu7G_O0dv96nX5WKyfH56Wi3VhmFC5IA6k9ZaUnqlSAYWmkUqyphSqstJKKnlFQTcV056Bo8JI23AtfANKMCvYHF3uc4cYPkaXcr1rk3Fdp3sXxlRTXjIhGacw0Yt_dBvG2E_fTUpUogQhykld7ZWJIaXofD3EdqfjV02g_mmyvoPly2-TK_YNYcNkcQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2467650665</pqid></control><display><type>article</type><title>Active targeting of gold nanoparticles as cancer therapeutics</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Goddard, Zoë Rachael ; Marín, María J. ; Russell, David A. ; Searcey, Mark</creator><creatorcontrib>Goddard, Zoë Rachael ; Marín, María J. ; Russell, David A. ; Searcey, Mark</creatorcontrib><description>Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug carriers. The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers, with antibodies, proteins, peptides, aptamers, carbohydrates and small molecules all exploited. Here, we review the recent advances in targeted-AuNPs for the treatment of cancer, with a particular focus on these classes of targeting ligands. We highlight the benefits and potential drawbacks of each ligand class and propose directions in which the field could grow.</description><identifier>ISSN: 0306-0012</identifier><identifier>EISSN: 1460-4744</identifier><identifier>DOI: 10.1039/d0cs01121e</identifier><language>eng</language><publisher>London: Royal Society of Chemistry</publisher><subject>Antibodies ; Cancer ; Carbohydrates ; Drug carriers ; Gold ; Ligands ; Nanoparticles ; Peptides ; Toxicity</subject><ispartof>Chemical Society reviews, 2020-12, Vol.49 (23), p.8774-8789</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-1e08dfd15f3959020bb8983b5697d8d8284720ab73af30e26c8db4a6fb0963d63</citedby><cites>FETCH-LOGICAL-c369t-1e08dfd15f3959020bb8983b5697d8d8284720ab73af30e26c8db4a6fb0963d63</cites><orcidid>0000-0002-7900-1553 ; 0000-0001-8021-5498 ; 0000-0003-2273-8949 ; 0000-0001-9915-4699</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Goddard, Zoë Rachael</creatorcontrib><creatorcontrib>Marín, María J.</creatorcontrib><creatorcontrib>Russell, David A.</creatorcontrib><creatorcontrib>Searcey, Mark</creatorcontrib><title>Active targeting of gold nanoparticles as cancer therapeutics</title><title>Chemical Society reviews</title><description>Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug carriers. The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers, with antibodies, proteins, peptides, aptamers, carbohydrates and small molecules all exploited. Here, we review the recent advances in targeted-AuNPs for the treatment of cancer, with a particular focus on these classes of targeting ligands. We highlight the benefits and potential drawbacks of each ligand class and propose directions in which the field could grow.</description><subject>Antibodies</subject><subject>Cancer</subject><subject>Carbohydrates</subject><subject>Drug carriers</subject><subject>Gold</subject><subject>Ligands</subject><subject>Nanoparticles</subject><subject>Peptides</subject><subject>Toxicity</subject><issn>0306-0012</issn><issn>1460-4744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpd0MtKxDAUBuAgCo6jG58g4EaE6smlabJwMYzjBQZcqOuS5jJ26DQ1SQXf3uq4cnUOnI-fw4_QOYFrAkzdWDAJCKHEHaAZ4QIKXnF-iGbAQBQAhB6jk5S200YqQWfodmFy--lw1nHjcttvcPB4EzqLe92HQcfcms4lrBM2ujcu4vzuoh7cOB3SKTryukvu7G_O0dv96nX5WKyfH56Wi3VhmFC5IA6k9ZaUnqlSAYWmkUqyphSqstJKKnlFQTcV056Bo8JI23AtfANKMCvYHF3uc4cYPkaXcr1rk3Fdp3sXxlRTXjIhGacw0Yt_dBvG2E_fTUpUogQhykld7ZWJIaXofD3EdqfjV02g_mmyvoPly2-TK_YNYcNkcQ</recordid><startdate>20201207</startdate><enddate>20201207</enddate><creator>Goddard, Zoë Rachael</creator><creator>Marín, María J.</creator><creator>Russell, David A.</creator><creator>Searcey, Mark</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7900-1553</orcidid><orcidid>https://orcid.org/0000-0001-8021-5498</orcidid><orcidid>https://orcid.org/0000-0003-2273-8949</orcidid><orcidid>https://orcid.org/0000-0001-9915-4699</orcidid></search><sort><creationdate>20201207</creationdate><title>Active targeting of gold nanoparticles as cancer therapeutics</title><author>Goddard, Zoë Rachael ; Marín, María J. ; Russell, David A. ; Searcey, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-1e08dfd15f3959020bb8983b5697d8d8284720ab73af30e26c8db4a6fb0963d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibodies</topic><topic>Cancer</topic><topic>Carbohydrates</topic><topic>Drug carriers</topic><topic>Gold</topic><topic>Ligands</topic><topic>Nanoparticles</topic><topic>Peptides</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goddard, Zoë Rachael</creatorcontrib><creatorcontrib>Marín, María J.</creatorcontrib><creatorcontrib>Russell, David A.</creatorcontrib><creatorcontrib>Searcey, Mark</creatorcontrib><collection>CrossRef</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical Society reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goddard, Zoë Rachael</au><au>Marín, María J.</au><au>Russell, David A.</au><au>Searcey, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Active targeting of gold nanoparticles as cancer therapeutics</atitle><jtitle>Chemical Society reviews</jtitle><date>2020-12-07</date><risdate>2020</risdate><volume>49</volume><issue>23</issue><spage>8774</spage><epage>8789</epage><pages>8774-8789</pages><issn>0306-0012</issn><eissn>1460-4744</eissn><abstract>Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug carriers. The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers, with antibodies, proteins, peptides, aptamers, carbohydrates and small molecules all exploited. Here, we review the recent advances in targeted-AuNPs for the treatment of cancer, with a particular focus on these classes of targeting ligands. We highlight the benefits and potential drawbacks of each ligand class and propose directions in which the field could grow.</abstract><cop>London</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d0cs01121e</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-7900-1553</orcidid><orcidid>https://orcid.org/0000-0001-8021-5498</orcidid><orcidid>https://orcid.org/0000-0003-2273-8949</orcidid><orcidid>https://orcid.org/0000-0001-9915-4699</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0306-0012
ispartof Chemical Society reviews, 2020-12, Vol.49 (23), p.8774-8789
issn 0306-0012
1460-4744
language eng
recordid cdi_proquest_miscellaneous_2453683420
source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Antibodies
Cancer
Carbohydrates
Drug carriers
Gold
Ligands
Nanoparticles
Peptides
Toxicity
title Active targeting of gold nanoparticles as cancer therapeutics
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T03%3A13%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Active%20targeting%20of%20gold%20nanoparticles%20as%20cancer%20therapeutics&rft.jtitle=Chemical%20Society%20reviews&rft.au=Goddard,%20Zo%C3%AB%20Rachael&rft.date=2020-12-07&rft.volume=49&rft.issue=23&rft.spage=8774&rft.epage=8789&rft.pages=8774-8789&rft.issn=0306-0012&rft.eissn=1460-4744&rft_id=info:doi/10.1039/d0cs01121e&rft_dat=%3Cproquest_cross%3E2453683420%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2467650665&rft_id=info:pmid/&rfr_iscdi=true