Development of DHQ-based chemical biology probe to profile cellular targets for HBV
[Display omitted] Chronic hepatitis B virus (HBV) infection has been a serious public health burden worldwide. Current anti-HBV therapies could not eliminate HBV ultimately. Considering the characteristics of HBV, it is impossible to be entirely cured based on current therapies. Therefore, it is urg...
Gespeichert in:
| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2020-12, Vol.30 (23), p.127615-127615, Article 127615 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 127615 |
|---|---|
| container_issue | 23 |
| container_start_page | 127615 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 30 |
| creator | Zhang, Qing Huang, Jianzhou Chow, Hoi Yee Wang, Jinzheng Zhang, Yingjun Fung, Yi Man Eva Ren, Qingyun Li, Xuechen |
| description | [Display omitted]
Chronic hepatitis B virus (HBV) infection has been a serious public health burden worldwide. Current anti-HBV therapies could not eliminate HBV ultimately. Considering the characteristics of HBV, it is impossible to be entirely cured based on current therapies. Therefore, it is urgently needed to develop novel therapeutic agents with new mechanism of action. The dihydroquinolizinone (DHQ) derivatives exhibited potent anti-HBV activity by decreasing HBV DNA and HBsAg level in an obscure mechanism of action. In this study, we have optimized the DHQ scaffold, developed the photoaffinity probe, with which to identify potential binding proteins. |
| doi_str_mv | 10.1016/j.bmcl.2020.127615 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2452984365</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0960894X20307265</els_id><sourcerecordid>2452984365</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-8d6305f52446cc39227f33f631ab4d717c43d78d50a9d34ff11127701cde08443</originalsourceid><addsrcrecordid>eNp9kEtrGzEUhUVpqJ20f6CLomU34-g9M5BNYqdxIBBCH3QnNNJVKqOxHGkcyL_vDHayzOpeLucc7vkQ-krJghKqzjeLrrdxwQgbD6xWVH5AcyqUqLgg8iOak1aRqmnF3xk6LWVDCBVEiE9oxjlpCJd0jn6u4Bli2vWwHXDyeLV-qDpTwGH7D_pgTcRdSDE9vuBdTh3gIU2LDxGwhRj30WQ8mPwIQ8E-Zby--vMZnXgTC3w5zjP0-8f1r-W6uru_uV1e3lWWSzVUjVOcSC-ZEMpa3jJWe8694tR0wtW0toK7unGSmNZx4T2lY8uaUOuANELwM_T9kDs-9LSHMug-lOkps4W0L5oJydpGcCVHKTtIbU6lZPB6l0Nv8oumRE8w9UZPMPUEUx9gjqZvx_x914N7s7zSGwUXBwGMLZ8DZF1sgK0FFzLYQbsU3sv_D4ZQg7U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2452984365</pqid></control><display><type>article</type><title>Development of DHQ-based chemical biology probe to profile cellular targets for HBV</title><source>ScienceDirect Journals (5 years ago - present)</source><creator>Zhang, Qing ; Huang, Jianzhou ; Chow, Hoi Yee ; Wang, Jinzheng ; Zhang, Yingjun ; Fung, Yi Man Eva ; Ren, Qingyun ; Li, Xuechen</creator><creatorcontrib>Zhang, Qing ; Huang, Jianzhou ; Chow, Hoi Yee ; Wang, Jinzheng ; Zhang, Yingjun ; Fung, Yi Man Eva ; Ren, Qingyun ; Li, Xuechen</creatorcontrib><description>[Display omitted]
Chronic hepatitis B virus (HBV) infection has been a serious public health burden worldwide. Current anti-HBV therapies could not eliminate HBV ultimately. Considering the characteristics of HBV, it is impossible to be entirely cured based on current therapies. Therefore, it is urgently needed to develop novel therapeutic agents with new mechanism of action. The dihydroquinolizinone (DHQ) derivatives exhibited potent anti-HBV activity by decreasing HBV DNA and HBsAg level in an obscure mechanism of action. In this study, we have optimized the DHQ scaffold, developed the photoaffinity probe, with which to identify potential binding proteins.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2020.127615</identifier><identifier>PMID: 33080351</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Activity-based proteome profiling (ABPP) ; Dihydroquinolizinone (DHQ) ; Hepatitis B virus (HBV) ; Photoaffinity labeling ; RNA stability</subject><ispartof>Bioorganic & medicinal chemistry letters, 2020-12, Vol.30 (23), p.127615-127615, Article 127615</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-8d6305f52446cc39227f33f631ab4d717c43d78d50a9d34ff11127701cde08443</citedby><cites>FETCH-LOGICAL-c356t-8d6305f52446cc39227f33f631ab4d717c43d78d50a9d34ff11127701cde08443</cites><orcidid>0000-0001-5465-7727</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2020.127615$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33080351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Qing</creatorcontrib><creatorcontrib>Huang, Jianzhou</creatorcontrib><creatorcontrib>Chow, Hoi Yee</creatorcontrib><creatorcontrib>Wang, Jinzheng</creatorcontrib><creatorcontrib>Zhang, Yingjun</creatorcontrib><creatorcontrib>Fung, Yi Man Eva</creatorcontrib><creatorcontrib>Ren, Qingyun</creatorcontrib><creatorcontrib>Li, Xuechen</creatorcontrib><title>Development of DHQ-based chemical biology probe to profile cellular targets for HBV</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>[Display omitted]
Chronic hepatitis B virus (HBV) infection has been a serious public health burden worldwide. Current anti-HBV therapies could not eliminate HBV ultimately. Considering the characteristics of HBV, it is impossible to be entirely cured based on current therapies. Therefore, it is urgently needed to develop novel therapeutic agents with new mechanism of action. The dihydroquinolizinone (DHQ) derivatives exhibited potent anti-HBV activity by decreasing HBV DNA and HBsAg level in an obscure mechanism of action. In this study, we have optimized the DHQ scaffold, developed the photoaffinity probe, with which to identify potential binding proteins.</description><subject>Activity-based proteome profiling (ABPP)</subject><subject>Dihydroquinolizinone (DHQ)</subject><subject>Hepatitis B virus (HBV)</subject><subject>Photoaffinity labeling</subject><subject>RNA stability</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kEtrGzEUhUVpqJ20f6CLomU34-g9M5BNYqdxIBBCH3QnNNJVKqOxHGkcyL_vDHayzOpeLucc7vkQ-krJghKqzjeLrrdxwQgbD6xWVH5AcyqUqLgg8iOak1aRqmnF3xk6LWVDCBVEiE9oxjlpCJd0jn6u4Bli2vWwHXDyeLV-qDpTwGH7D_pgTcRdSDE9vuBdTh3gIU2LDxGwhRj30WQ8mPwIQ8E-Zby--vMZnXgTC3w5zjP0-8f1r-W6uru_uV1e3lWWSzVUjVOcSC-ZEMpa3jJWe8694tR0wtW0toK7unGSmNZx4T2lY8uaUOuANELwM_T9kDs-9LSHMug-lOkps4W0L5oJydpGcCVHKTtIbU6lZPB6l0Nv8oumRE8w9UZPMPUEUx9gjqZvx_x914N7s7zSGwUXBwGMLZ8DZF1sgK0FFzLYQbsU3sv_D4ZQg7U</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Zhang, Qing</creator><creator>Huang, Jianzhou</creator><creator>Chow, Hoi Yee</creator><creator>Wang, Jinzheng</creator><creator>Zhang, Yingjun</creator><creator>Fung, Yi Man Eva</creator><creator>Ren, Qingyun</creator><creator>Li, Xuechen</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5465-7727</orcidid></search><sort><creationdate>20201201</creationdate><title>Development of DHQ-based chemical biology probe to profile cellular targets for HBV</title><author>Zhang, Qing ; Huang, Jianzhou ; Chow, Hoi Yee ; Wang, Jinzheng ; Zhang, Yingjun ; Fung, Yi Man Eva ; Ren, Qingyun ; Li, Xuechen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-8d6305f52446cc39227f33f631ab4d717c43d78d50a9d34ff11127701cde08443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Activity-based proteome profiling (ABPP)</topic><topic>Dihydroquinolizinone (DHQ)</topic><topic>Hepatitis B virus (HBV)</topic><topic>Photoaffinity labeling</topic><topic>RNA stability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Qing</creatorcontrib><creatorcontrib>Huang, Jianzhou</creatorcontrib><creatorcontrib>Chow, Hoi Yee</creatorcontrib><creatorcontrib>Wang, Jinzheng</creatorcontrib><creatorcontrib>Zhang, Yingjun</creatorcontrib><creatorcontrib>Fung, Yi Man Eva</creatorcontrib><creatorcontrib>Ren, Qingyun</creatorcontrib><creatorcontrib>Li, Xuechen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Qing</au><au>Huang, Jianzhou</au><au>Chow, Hoi Yee</au><au>Wang, Jinzheng</au><au>Zhang, Yingjun</au><au>Fung, Yi Man Eva</au><au>Ren, Qingyun</au><au>Li, Xuechen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of DHQ-based chemical biology probe to profile cellular targets for HBV</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>30</volume><issue>23</issue><spage>127615</spage><epage>127615</epage><pages>127615-127615</pages><artnum>127615</artnum><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>[Display omitted]
Chronic hepatitis B virus (HBV) infection has been a serious public health burden worldwide. Current anti-HBV therapies could not eliminate HBV ultimately. Considering the characteristics of HBV, it is impossible to be entirely cured based on current therapies. Therefore, it is urgently needed to develop novel therapeutic agents with new mechanism of action. The dihydroquinolizinone (DHQ) derivatives exhibited potent anti-HBV activity by decreasing HBV DNA and HBsAg level in an obscure mechanism of action. In this study, we have optimized the DHQ scaffold, developed the photoaffinity probe, with which to identify potential binding proteins.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33080351</pmid><doi>10.1016/j.bmcl.2020.127615</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-5465-7727</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2020-12, Vol.30 (23), p.127615-127615, Article 127615 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2452984365 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Activity-based proteome profiling (ABPP) Dihydroquinolizinone (DHQ) Hepatitis B virus (HBV) Photoaffinity labeling RNA stability |
| title | Development of DHQ-based chemical biology probe to profile cellular targets for HBV |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T01%3A47%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20DHQ-based%20chemical%20biology%20probe%20to%20profile%20cellular%20targets%20for%20HBV&rft.jtitle=Bioorganic%20&%20medicinal%20chemistry%20letters&rft.au=Zhang,%20Qing&rft.date=2020-12-01&rft.volume=30&rft.issue=23&rft.spage=127615&rft.epage=127615&rft.pages=127615-127615&rft.artnum=127615&rft.issn=0960-894X&rft.eissn=1464-3405&rft_id=info:doi/10.1016/j.bmcl.2020.127615&rft_dat=%3Cproquest_cross%3E2452984365%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2452984365&rft_id=info:pmid/33080351&rft_els_id=S0960894X20307265&rfr_iscdi=true |