Dihydromyricetin improves mitochondrial outcomes in the liver of alcohol-fed mice via the AMPK/Sirt-1/PGC-1α signaling axis

Alcoholic liver disease (ALD), due to the multifactorial damage associated with alcohol (ethanol) consumption and metabolism, is one of the most prevalent liver diseases in the United States. The liver is the primary site of ethanol metabolism and is subsequently injured due to the production of rea...

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Veröffentlicht in:	Alcohol (Fayetteville, N.Y.) N.Y.), 2021-03, Vol.91, p.1-9
Hauptverfasser:	Silva, Joshua, Spatz, Maximilian H., Folk, Carson, Chang, Arnold, Cadenas, Enrique, Liang, Jing, Davies, Daryl L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde Alcohol Alcohol use Alcoholic liver disease (ALD) Alcoholism Alcoholism - drug therapy Alcoholism - physiopathology AMP AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Animals Bioenergetics Biosynthesis Cytochrome Dehydrogenases Deoxyribonucleic acid Dihydromyricetin DNA Drinking behavior Ethanol Flavonoids Flavonols - pharmacology Kinases Lipid peroxidation Liver Liver - drug effects Liver - metabolism Liver diseases Male Metabolic disorders Metabolism Metabolites Mice Mice, Inbred C57BL Mitochondria Mitochondria, Liver - drug effects Mitochondrial DNA Oxidative stress Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Peroxisome proliferator-activated receptors PGC-1α Phosphorylation PPAR gamma Proteins Reactive oxygen species Signal Transduction Sirtuin Sirtuin 1 - metabolism
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