Bladder outlet obstruction is associated with bladder oversensitivity in women
Introduction and hypothesis Bladder outlet obstruction (BOO) in women might be associated with significant lower urinary tract storage symptoms such as increased frequency, urgency, and incontinence. This prospective study was designed to assess whether there is an objective association between BOO...
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| Veröffentlicht in: | International Urogynecology Journal 2021-10, Vol.32 (10), p.2771-2776 |
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| creator | Verhovsky, Guy Rappaport, Yishai Hode Baberashvili, Ilia Neheman, Amos Zisman, Amnon Stav, Kobi |
| description | Introduction and hypothesis
Bladder outlet obstruction (BOO) in women might be associated with significant lower urinary tract storage symptoms such as increased frequency, urgency, and incontinence. This prospective study was designed to assess whether there is an objective association between BOO and abnormal parameters during filling cystometry in women.
Methods
A total of 169 consecutive women (mean age 56 ± 14 years) who were referred for urodynamic investigation were prospectively recruited. Comprehensive medical, obstetric, and gynecological histories were recorded. All patients underwent physical examination, renal and bladder ultrasound, and filled out the International Prostate Symptoms Score (IPSS) questionnaire. The cohort was divided into obstructed and un-obstructed groups based on pressure flow results (Obstruction: Q
max
25 cmH
2
O).
Result
There was no significant difference in the frequency of detrusor overactivity between the obstructed and non-obstructed group (37% vs 32%,
p
= 0.71). All bladder sensation volumes were significantly lower in obstructed women than non-obstructed women in univariate and multivariate logistic regression analyses. Of the sensation parameters, first desire to void (FDV) had the highest area under the curve (AUC = 0.75, 95% CI = 0.672–0.837,
p
|
| doi_str_mv | 10.1007/s00192-020-04561-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2452982406</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2574928854</sourcerecordid><originalsourceid>FETCH-LOGICAL-c352t-a145a67ccff963433c8acdabe707787456a45f5f92eb2772c5452b14be19784c3</originalsourceid><addsrcrecordid>eNp9kDtPwzAUhS0EEqXwB5gisbAYrl9xMkLFS6pggdlyHAdcpXGxnVb99xgKQmJgust3js79EDolcEEA5GUEIDXFQAEDFyXBYg9NCGcMM6BsH02gZhIzXtJDdBTjAgA4CJigx-tet60NhR9Tb1Phm5jCaJLzQ-FioWP0xulk22Lj0lvR_NBrG6Idoktu7dK2cEOx8Us7HKODTvfRnnzfKXq5vXme3eP5093D7GqODRM0YU240KU0puvqkuWZptKm1Y2VIGUl8weai050NbUNlZIawQVtCG8sqWXFDZui813vKvj30cakli4a2_d6sH6Mima-riiHMqNnf9CFH8OQ1ykqJK9pVQmeKbqjTPAxBtupVXBLHbaKgPpUrHaKVVasvhQrkUNsF4oZHl5t-K3-J_UBjKl-kQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2574928854</pqid></control><display><type>article</type><title>Bladder outlet obstruction is associated with bladder oversensitivity in women</title><source>Springer Journals</source><creator>Verhovsky, Guy ; Rappaport, Yishai Hode ; Baberashvili, Ilia ; Neheman, Amos ; Zisman, Amnon ; Stav, Kobi</creator><creatorcontrib>Verhovsky, Guy ; Rappaport, Yishai Hode ; Baberashvili, Ilia ; Neheman, Amos ; Zisman, Amnon ; Stav, Kobi</creatorcontrib><description>Introduction and hypothesis
Bladder outlet obstruction (BOO) in women might be associated with significant lower urinary tract storage symptoms such as increased frequency, urgency, and incontinence. This prospective study was designed to assess whether there is an objective association between BOO and abnormal parameters during filling cystometry in women.
Methods
A total of 169 consecutive women (mean age 56 ± 14 years) who were referred for urodynamic investigation were prospectively recruited. Comprehensive medical, obstetric, and gynecological histories were recorded. All patients underwent physical examination, renal and bladder ultrasound, and filled out the International Prostate Symptoms Score (IPSS) questionnaire. The cohort was divided into obstructed and un-obstructed groups based on pressure flow results (Obstruction: Q
max
<12 ml/s and P
det
@ Q
max
>25 cmH
2
O).
Result
There was no significant difference in the frequency of detrusor overactivity between the obstructed and non-obstructed group (37% vs 32%,
p
= 0.71). All bladder sensation volumes were significantly lower in obstructed women than non-obstructed women in univariate and multivariate logistic regression analyses. Of the sensation parameters, first desire to void (FDV) had the highest area under the curve (AUC = 0.75, 95% CI = 0.672–0.837,
p
< 0.001) for predicting BOO. FDV < 105 ml showed a strong association with BOO with OR = 9.84 (95% CI 4.122–23.508,
p
< 0.0001). On univariate and multivariate analyses adjusted to 50 cc reduction in sensation volume, all sensation parameters, were associated with bladder outlet obstruction.
Conclusion
Our results suggest that there might be a strong association between bladder oversensitivity and BOO in women. This may shed light on the pathophysiological connection between obstruction and enhanced afferent signaling from the bladder.</description><identifier>ISSN: 0937-3462</identifier><identifier>EISSN: 1433-3023</identifier><identifier>DOI: 10.1007/s00192-020-04561-5</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Bladder ; Catheters ; Gynecology ; Medicine ; Medicine & Public Health ; Obstetrics ; Original Article ; Pain ; Prostate ; Urogenital system ; Urology</subject><ispartof>International Urogynecology Journal, 2021-10, Vol.32 (10), p.2771-2776</ispartof><rights>The International Urogynecological Association 2020</rights><rights>The International Urogynecological Association 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-a145a67ccff963433c8acdabe707787456a45f5f92eb2772c5452b14be19784c3</citedby><cites>FETCH-LOGICAL-c352t-a145a67ccff963433c8acdabe707787456a45f5f92eb2772c5452b14be19784c3</cites><orcidid>0000-0002-2954-9852</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00192-020-04561-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00192-020-04561-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Verhovsky, Guy</creatorcontrib><creatorcontrib>Rappaport, Yishai Hode</creatorcontrib><creatorcontrib>Baberashvili, Ilia</creatorcontrib><creatorcontrib>Neheman, Amos</creatorcontrib><creatorcontrib>Zisman, Amnon</creatorcontrib><creatorcontrib>Stav, Kobi</creatorcontrib><title>Bladder outlet obstruction is associated with bladder oversensitivity in women</title><title>International Urogynecology Journal</title><addtitle>Int Urogynecol J</addtitle><description>Introduction and hypothesis
Bladder outlet obstruction (BOO) in women might be associated with significant lower urinary tract storage symptoms such as increased frequency, urgency, and incontinence. This prospective study was designed to assess whether there is an objective association between BOO and abnormal parameters during filling cystometry in women.
Methods
A total of 169 consecutive women (mean age 56 ± 14 years) who were referred for urodynamic investigation were prospectively recruited. Comprehensive medical, obstetric, and gynecological histories were recorded. All patients underwent physical examination, renal and bladder ultrasound, and filled out the International Prostate Symptoms Score (IPSS) questionnaire. The cohort was divided into obstructed and un-obstructed groups based on pressure flow results (Obstruction: Q
max
<12 ml/s and P
det
@ Q
max
>25 cmH
2
O).
Result
There was no significant difference in the frequency of detrusor overactivity between the obstructed and non-obstructed group (37% vs 32%,
p
= 0.71). All bladder sensation volumes were significantly lower in obstructed women than non-obstructed women in univariate and multivariate logistic regression analyses. Of the sensation parameters, first desire to void (FDV) had the highest area under the curve (AUC = 0.75, 95% CI = 0.672–0.837,
p
< 0.001) for predicting BOO. FDV < 105 ml showed a strong association with BOO with OR = 9.84 (95% CI 4.122–23.508,
p
< 0.0001). On univariate and multivariate analyses adjusted to 50 cc reduction in sensation volume, all sensation parameters, were associated with bladder outlet obstruction.
Conclusion
Our results suggest that there might be a strong association between bladder oversensitivity and BOO in women. This may shed light on the pathophysiological connection between obstruction and enhanced afferent signaling from the bladder.</description><subject>Bladder</subject><subject>Catheters</subject><subject>Gynecology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics</subject><subject>Original Article</subject><subject>Pain</subject><subject>Prostate</subject><subject>Urogenital system</subject><subject>Urology</subject><issn>0937-3462</issn><issn>1433-3023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kDtPwzAUhS0EEqXwB5gisbAYrl9xMkLFS6pggdlyHAdcpXGxnVb99xgKQmJgust3js79EDolcEEA5GUEIDXFQAEDFyXBYg9NCGcMM6BsH02gZhIzXtJDdBTjAgA4CJigx-tet60NhR9Tb1Phm5jCaJLzQ-FioWP0xulk22Lj0lvR_NBrG6Idoktu7dK2cEOx8Us7HKODTvfRnnzfKXq5vXme3eP5093D7GqODRM0YU240KU0puvqkuWZptKm1Y2VIGUl8weai050NbUNlZIawQVtCG8sqWXFDZui813vKvj30cakli4a2_d6sH6Mima-riiHMqNnf9CFH8OQ1ykqJK9pVQmeKbqjTPAxBtupVXBLHbaKgPpUrHaKVVasvhQrkUNsF4oZHl5t-K3-J_UBjKl-kQ</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Verhovsky, Guy</creator><creator>Rappaport, Yishai Hode</creator><creator>Baberashvili, Ilia</creator><creator>Neheman, Amos</creator><creator>Zisman, Amnon</creator><creator>Stav, Kobi</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2954-9852</orcidid></search><sort><creationdate>20211001</creationdate><title>Bladder outlet obstruction is associated with bladder oversensitivity in women</title><author>Verhovsky, Guy ; Rappaport, Yishai Hode ; Baberashvili, Ilia ; Neheman, Amos ; Zisman, Amnon ; Stav, Kobi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-a145a67ccff963433c8acdabe707787456a45f5f92eb2772c5452b14be19784c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bladder</topic><topic>Catheters</topic><topic>Gynecology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics</topic><topic>Original Article</topic><topic>Pain</topic><topic>Prostate</topic><topic>Urogenital system</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verhovsky, Guy</creatorcontrib><creatorcontrib>Rappaport, Yishai Hode</creatorcontrib><creatorcontrib>Baberashvili, Ilia</creatorcontrib><creatorcontrib>Neheman, Amos</creatorcontrib><creatorcontrib>Zisman, Amnon</creatorcontrib><creatorcontrib>Stav, Kobi</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International Urogynecology Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verhovsky, Guy</au><au>Rappaport, Yishai Hode</au><au>Baberashvili, Ilia</au><au>Neheman, Amos</au><au>Zisman, Amnon</au><au>Stav, Kobi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bladder outlet obstruction is associated with bladder oversensitivity in women</atitle><jtitle>International Urogynecology Journal</jtitle><stitle>Int Urogynecol J</stitle><date>2021-10-01</date><risdate>2021</risdate><volume>32</volume><issue>10</issue><spage>2771</spage><epage>2776</epage><pages>2771-2776</pages><issn>0937-3462</issn><eissn>1433-3023</eissn><abstract>Introduction and hypothesis
Bladder outlet obstruction (BOO) in women might be associated with significant lower urinary tract storage symptoms such as increased frequency, urgency, and incontinence. This prospective study was designed to assess whether there is an objective association between BOO and abnormal parameters during filling cystometry in women.
Methods
A total of 169 consecutive women (mean age 56 ± 14 years) who were referred for urodynamic investigation were prospectively recruited. Comprehensive medical, obstetric, and gynecological histories were recorded. All patients underwent physical examination, renal and bladder ultrasound, and filled out the International Prostate Symptoms Score (IPSS) questionnaire. The cohort was divided into obstructed and un-obstructed groups based on pressure flow results (Obstruction: Q
max
<12 ml/s and P
det
@ Q
max
>25 cmH
2
O).
Result
There was no significant difference in the frequency of detrusor overactivity between the obstructed and non-obstructed group (37% vs 32%,
p
= 0.71). All bladder sensation volumes were significantly lower in obstructed women than non-obstructed women in univariate and multivariate logistic regression analyses. Of the sensation parameters, first desire to void (FDV) had the highest area under the curve (AUC = 0.75, 95% CI = 0.672–0.837,
p
< 0.001) for predicting BOO. FDV < 105 ml showed a strong association with BOO with OR = 9.84 (95% CI 4.122–23.508,
p
< 0.0001). On univariate and multivariate analyses adjusted to 50 cc reduction in sensation volume, all sensation parameters, were associated with bladder outlet obstruction.
Conclusion
Our results suggest that there might be a strong association between bladder oversensitivity and BOO in women. This may shed light on the pathophysiological connection between obstruction and enhanced afferent signaling from the bladder.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s00192-020-04561-5</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-2954-9852</orcidid></addata></record> |
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| source | Springer Journals |
| subjects | Bladder Catheters Gynecology Medicine Medicine & Public Health Obstetrics Original Article Pain Prostate Urogenital system Urology |
| title | Bladder outlet obstruction is associated with bladder oversensitivity in women |
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