Prognostic value of left ventricular mechanical dyssynchrony induced by exercise stress in patients with normal myocardial perfusion single-photon emission computed tomography
Left ventricular mechanical dyssynchrony (LVMD) induced by exercise stress was reported to be clinically useful in detecting multivessel coronary artery diseases. The aim of this study was to compare the prognostic value of LVMD induced by pharmacological stress with that induced by exercise stress....
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| Veröffentlicht in: | Journal of nuclear cardiology 2022-06, Vol.29 (3), p.965-974 |
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| container_title | Journal of nuclear cardiology |
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| creator | Sakatani, Tomohiko Kasahara, Takeru Irie, Daisuke Tsubakimoto, Yoshinori Matsuo, Akiko Fujita, Hiroshi Inoue, Keiji |
| description | Left ventricular mechanical dyssynchrony (LVMD) induced by exercise stress was reported to be clinically useful in detecting multivessel coronary artery diseases. The aim of this study was to compare the prognostic value of LVMD induced by pharmacological stress with that induced by exercise stress.
We retrospectively examined 918 consecutive patients who underwent exercise (N = 310) or pharmacological stress (N = 608) 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) with normal myocardial perfusion. LVMD was evaluated by phase analysis as the indices of phase bandwidth and phase standard deviation (PSD).
During the follow-up period (2.2 ± 1.9 years), 74 major cardiac events (MCEs) occurred (7 cases of cardiac death, 17 cases of heart failure, and 50 cases of coronary intervention). In global patients, the indices of LVMD on rest images were significantly greater in patients with MCEs (bandwidth (°): 51 ± 31 vs 37 ± 21, P = .001, PSD: 14 ± 9 vs 10 ± 6, P = .001). The exercise stress bandwidth was significantly higher in patients with MCEs (62 ± 37° vs 42 ± 21°, P = .026), as was the pharmacological stress bandwidth (57 ± 35° vs 43 ± 24°, P = .006). Multivariate analysis demonstrated the exercise stress bandwidth to be an independent predictor of MCEs (HR 1.017, CI 1.003 to 1.032, P = .019), but the pharmacological stress bandwidth had no influence on MCEs.
LVMD induced by exercise stress was an independent predictor of MCEs in patients with normal perfusion SPECT, whereas that induced by pharmacological stress had no association with further events. |
| doi_str_mv | 10.1007/s12350-020-02389-6 |
| format | Article |
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We retrospectively examined 918 consecutive patients who underwent exercise (N = 310) or pharmacological stress (N = 608) 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) with normal myocardial perfusion. LVMD was evaluated by phase analysis as the indices of phase bandwidth and phase standard deviation (PSD).
During the follow-up period (2.2 ± 1.9 years), 74 major cardiac events (MCEs) occurred (7 cases of cardiac death, 17 cases of heart failure, and 50 cases of coronary intervention). In global patients, the indices of LVMD on rest images were significantly greater in patients with MCEs (bandwidth (°): 51 ± 31 vs 37 ± 21, P = .001, PSD: 14 ± 9 vs 10 ± 6, P = .001). The exercise stress bandwidth was significantly higher in patients with MCEs (62 ± 37° vs 42 ± 21°, P = .026), as was the pharmacological stress bandwidth (57 ± 35° vs 43 ± 24°, P = .006). Multivariate analysis demonstrated the exercise stress bandwidth to be an independent predictor of MCEs (HR 1.017, CI 1.003 to 1.032, P = .019), but the pharmacological stress bandwidth had no influence on MCEs.
LVMD induced by exercise stress was an independent predictor of MCEs in patients with normal perfusion SPECT, whereas that induced by pharmacological stress had no association with further events.</description><identifier>ISSN: 1071-3581</identifier><identifier>EISSN: 1532-6551</identifier><identifier>DOI: 10.1007/s12350-020-02389-6</identifier><identifier>PMID: 33083982</identifier><language>eng</language><publisher>Cham: Elsevier Inc</publisher><subject>99mTc-tetrofosmin ; Bandwidths ; cardiac events ; Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography - methods ; Cardiology ; exercise and pharmacological stress ; Humans ; Imaging ; Medical prognosis ; Medicine ; Medicine & Public Health ; Myocardial Perfusion Imaging - methods ; Nuclear Medicine ; Original Article ; Perfusion ; phase analysis ; Prognosis ; Radiology ; Retrospective Studies ; Tomography ; Tomography, Emission-Computed, Single-Photon ; Ventricular Dysfunction, Left - diagnostic imaging</subject><ispartof>Journal of nuclear cardiology, 2022-06, Vol.29 (3), p.965-974</ispartof><rights>2022 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved.</rights><rights>American Society of Nuclear Cardiology 2020</rights><rights>2020. American Society of Nuclear Cardiology.</rights><rights>American Society of Nuclear Cardiology 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-f84b8657a2bc6b628a02f6cf58dbed16d3b5e94a810304fa4575bbe87f0498f13</citedby><cites>FETCH-LOGICAL-c428t-f84b8657a2bc6b628a02f6cf58dbed16d3b5e94a810304fa4575bbe87f0498f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12350-020-02389-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12350-020-02389-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33083982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakatani, Tomohiko</creatorcontrib><creatorcontrib>Kasahara, Takeru</creatorcontrib><creatorcontrib>Irie, Daisuke</creatorcontrib><creatorcontrib>Tsubakimoto, Yoshinori</creatorcontrib><creatorcontrib>Matsuo, Akiko</creatorcontrib><creatorcontrib>Fujita, Hiroshi</creatorcontrib><creatorcontrib>Inoue, Keiji</creatorcontrib><title>Prognostic value of left ventricular mechanical dyssynchrony induced by exercise stress in patients with normal myocardial perfusion single-photon emission computed tomography</title><title>Journal of nuclear cardiology</title><addtitle>J. Nucl. Cardiol</addtitle><addtitle>J Nucl Cardiol</addtitle><description>Left ventricular mechanical dyssynchrony (LVMD) induced by exercise stress was reported to be clinically useful in detecting multivessel coronary artery diseases. The aim of this study was to compare the prognostic value of LVMD induced by pharmacological stress with that induced by exercise stress.
We retrospectively examined 918 consecutive patients who underwent exercise (N = 310) or pharmacological stress (N = 608) 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) with normal myocardial perfusion. LVMD was evaluated by phase analysis as the indices of phase bandwidth and phase standard deviation (PSD).
During the follow-up period (2.2 ± 1.9 years), 74 major cardiac events (MCEs) occurred (7 cases of cardiac death, 17 cases of heart failure, and 50 cases of coronary intervention). In global patients, the indices of LVMD on rest images were significantly greater in patients with MCEs (bandwidth (°): 51 ± 31 vs 37 ± 21, P = .001, PSD: 14 ± 9 vs 10 ± 6, P = .001). The exercise stress bandwidth was significantly higher in patients with MCEs (62 ± 37° vs 42 ± 21°, P = .026), as was the pharmacological stress bandwidth (57 ± 35° vs 43 ± 24°, P = .006). Multivariate analysis demonstrated the exercise stress bandwidth to be an independent predictor of MCEs (HR 1.017, CI 1.003 to 1.032, P = .019), but the pharmacological stress bandwidth had no influence on MCEs.
LVMD induced by exercise stress was an independent predictor of MCEs in patients with normal perfusion SPECT, whereas that induced by pharmacological stress had no association with further events.</description><subject>99mTc-tetrofosmin</subject><subject>Bandwidths</subject><subject>cardiac events</subject><subject>Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography - methods</subject><subject>Cardiology</subject><subject>exercise and pharmacological stress</subject><subject>Humans</subject><subject>Imaging</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Myocardial Perfusion Imaging - methods</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>Perfusion</subject><subject>phase analysis</subject><subject>Prognosis</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Tomography</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><issn>1071-3581</issn><issn>1532-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1TAQhiMEohd4ARbIEhs2AV_ixJHYoAoKUiVYwNpynPE5rhI7eJxT8lS8Im5PAYlFF5Yv8_-_R_NV1QtG3zBKu7fIuJC0pvx2CdXX7aPqlEnB61ZK9ricacdqIRU7qc4Qrymlvej7p9WJEFSJXvHT6tfXFHchYvaWHMy0AomOTOAyOUDIydt1MonMYPcmeGsmMm6IW7D7FMNGfBhXCyMZNgI_IVmPQDAnQCwlspjsSwiSG5_3JMQ0F_-8RWvS6MtxgeRW9DEQ9GE3Qb3sYy43mD3ePds4L2su-TnOcZfMst-eVU-cmRCe3-_n1fePH75dfKqvvlx-vnh_VduGq1w71QyqlZ3hg22HlitDuWutk2ocYGTtKAYJfWMUo4I2zjSyk8MAqnO06ZVj4rx6fcxdUvyxAmZdmrIwTSZAXFHzRvJelYHyIn31n_Q6rimU7jRvO96JTvSyqPhRZVNETOD0kvxs0qYZ1bc49RGnLjj1HU7dFtPL--h1mGH8a_nDrwjEUYClFHaQ_v39YOy7owvKBA--uNAWUoWkT2CzHqN_yP4blovD8Q</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Sakatani, Tomohiko</creator><creator>Kasahara, Takeru</creator><creator>Irie, Daisuke</creator><creator>Tsubakimoto, Yoshinori</creator><creator>Matsuo, Akiko</creator><creator>Fujita, Hiroshi</creator><creator>Inoue, Keiji</creator><general>Elsevier Inc</general><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20220601</creationdate><title>Prognostic value of left ventricular mechanical dyssynchrony induced by exercise stress in patients with normal myocardial perfusion single-photon emission computed tomography</title><author>Sakatani, Tomohiko ; Kasahara, Takeru ; Irie, Daisuke ; Tsubakimoto, Yoshinori ; Matsuo, Akiko ; Fujita, Hiroshi ; Inoue, Keiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-f84b8657a2bc6b628a02f6cf58dbed16d3b5e94a810304fa4575bbe87f0498f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>99mTc-tetrofosmin</topic><topic>Bandwidths</topic><topic>cardiac events</topic><topic>Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography - methods</topic><topic>Cardiology</topic><topic>exercise and pharmacological stress</topic><topic>Humans</topic><topic>Imaging</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Myocardial Perfusion Imaging - methods</topic><topic>Nuclear Medicine</topic><topic>Original Article</topic><topic>Perfusion</topic><topic>phase analysis</topic><topic>Prognosis</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Tomography</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakatani, Tomohiko</creatorcontrib><creatorcontrib>Kasahara, Takeru</creatorcontrib><creatorcontrib>Irie, Daisuke</creatorcontrib><creatorcontrib>Tsubakimoto, Yoshinori</creatorcontrib><creatorcontrib>Matsuo, Akiko</creatorcontrib><creatorcontrib>Fujita, Hiroshi</creatorcontrib><creatorcontrib>Inoue, Keiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of nuclear cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakatani, Tomohiko</au><au>Kasahara, Takeru</au><au>Irie, Daisuke</au><au>Tsubakimoto, Yoshinori</au><au>Matsuo, Akiko</au><au>Fujita, Hiroshi</au><au>Inoue, Keiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of left ventricular mechanical dyssynchrony induced by exercise stress in patients with normal myocardial perfusion single-photon emission computed tomography</atitle><jtitle>Journal of nuclear cardiology</jtitle><stitle>J. Nucl. Cardiol</stitle><addtitle>J Nucl Cardiol</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>29</volume><issue>3</issue><spage>965</spage><epage>974</epage><pages>965-974</pages><issn>1071-3581</issn><eissn>1532-6551</eissn><abstract>Left ventricular mechanical dyssynchrony (LVMD) induced by exercise stress was reported to be clinically useful in detecting multivessel coronary artery diseases. The aim of this study was to compare the prognostic value of LVMD induced by pharmacological stress with that induced by exercise stress.
We retrospectively examined 918 consecutive patients who underwent exercise (N = 310) or pharmacological stress (N = 608) 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) with normal myocardial perfusion. LVMD was evaluated by phase analysis as the indices of phase bandwidth and phase standard deviation (PSD).
During the follow-up period (2.2 ± 1.9 years), 74 major cardiac events (MCEs) occurred (7 cases of cardiac death, 17 cases of heart failure, and 50 cases of coronary intervention). In global patients, the indices of LVMD on rest images were significantly greater in patients with MCEs (bandwidth (°): 51 ± 31 vs 37 ± 21, P = .001, PSD: 14 ± 9 vs 10 ± 6, P = .001). The exercise stress bandwidth was significantly higher in patients with MCEs (62 ± 37° vs 42 ± 21°, P = .026), as was the pharmacological stress bandwidth (57 ± 35° vs 43 ± 24°, P = .006). Multivariate analysis demonstrated the exercise stress bandwidth to be an independent predictor of MCEs (HR 1.017, CI 1.003 to 1.032, P = .019), but the pharmacological stress bandwidth had no influence on MCEs.
LVMD induced by exercise stress was an independent predictor of MCEs in patients with normal perfusion SPECT, whereas that induced by pharmacological stress had no association with further events.</abstract><cop>Cham</cop><pub>Elsevier Inc</pub><pmid>33083982</pmid><doi>10.1007/s12350-020-02389-6</doi><tpages>10</tpages></addata></record> |
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| subjects | 99mTc-tetrofosmin Bandwidths cardiac events Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography - methods Cardiology exercise and pharmacological stress Humans Imaging Medical prognosis Medicine Medicine & Public Health Myocardial Perfusion Imaging - methods Nuclear Medicine Original Article Perfusion phase analysis Prognosis Radiology Retrospective Studies Tomography Tomography, Emission-Computed, Single-Photon Ventricular Dysfunction, Left - diagnostic imaging |
| title | Prognostic value of left ventricular mechanical dyssynchrony induced by exercise stress in patients with normal myocardial perfusion single-photon emission computed tomography |
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