Comprehensive profiling of the chemical components and potential markers in raw and processed Cistanche tubulosa by combining ultra-high-performance liquid chromatography coupled with tandem mass spectrometry and MS/MS-based molecular networking
Chinese materia medica processing is a distinguished and unique pharmaceutical technique in traditional Chinese medicine (TCM), which has played an important role in reducing side effects, increasing medical potencies, altering the properties and even changing the curative effects of raw herbs. The...
Gespeichert in:
| Veröffentlicht in: | Analytical and bioanalytical chemistry 2021-01, Vol.413 (1), p.129-139 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 139 |
|---|---|
| container_issue | 1 |
| container_start_page | 129 |
| container_title | Analytical and bioanalytical chemistry |
| container_volume | 413 |
| creator | Lei, Huibo Zhang, Yuhao Zu, Xianpeng Ye, Ji Liang, Yanlin Cheng, Taofang Zhang, Weidong |
| description | Chinese materia medica processing is a distinguished and unique pharmaceutical technique in traditional Chinese medicine (TCM), which has played an important role in reducing side effects, increasing medical potencies, altering the properties and even changing the curative effects of raw herbs. The efficacy improvement in medicinal plants is mainly caused by changes in the key substances through an optimized processing procedure. Thus, the use of a rapid method for determining suitable chemical markers between raw and processed TCM is critical in order to elucidate how the bioactive compounds influence the clinical effects. In this study, ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry combined with MS/MS-based molecular networking (MN) and a multivariate statistical analysis method is proposed for the first time. This combination was used to identify the complex chemical composition and clarify the changed constituents between raw and processed
Cistanche tubulosa
(
C. tubulosa
). The chemical analysis results demonstrated that a total of 85 compounds were identified in the crude and processed
C. tubulosa
. Moreover, 34 compounds were detected as chemical markers. This systematic research into chemical constituents and chemical markers of crude and processed
C. tubulosa
lays a solid foundation for further study of the quality control of
C. tubulosa
. Moreover, the study provides a new and valuable technical strategy for analyzing chemical components and identifying potential chemical markers for the processing of herbal medicines.
Graphical abstract |
| doi_str_mv | 10.1007/s00216-020-02983-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2452508121</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A650846629</galeid><sourcerecordid>A650846629</sourcerecordid><originalsourceid>FETCH-LOGICAL-c479t-5a993b530113c1934ab7a07313818468f6acac681f4333974362d4b697c45cb23</originalsourceid><addsrcrecordid>eNp9kktv1TAQhSMEoqXwB1ggS2zYpPUjz2V1xUtqxaKwthxncuPWsVPb6dX94eyZ9JZWIISiKJbmO2cmnpNlbxk9ZZTWZ5FSzqqccopv24icPsuOWcWanFclff54LvhR9irGa0pZ2bDqZXYkBK1bzvhx9nPjpznACC6aOyBz8IOxxm2JH0gagegRJqOVJRo578ClSJTryewTng0WJhVuIERiHAlqdygGryFG6MnGxKQcmpC0dIv1UZFuv3p1xq1dFpuCykezHfMZwuDDhDQQa24X02Pz4CeV_DaoeVxly2zRdGfSSNC2hwm7x0jiDDohCins7we4vDq7vMo7tY4weQt6sSoQB2nnww32fZ29GJSN8Obhe5L9-PTx--ZLfvHt89fN-UWui7pNeanaVnSloIwJzVpRqK5WtBZMNKwpqmaolFa6athQCCHauhAV74uuamtdlLrj4iT7cPDFG7ldICY5majBWuXAL1HyouQlbRhniL7_C732S3A4HVJ1Va8dyidqqyxI4waP96dXU3mOO8ehKt4idfoPCp9-XSZuEXcMfwr4QaCDjzHAIOdgcLF7yahcsyYPWZOYNXmfNUlR9O5h4qWboH-U_A4XAuIARCy5LYSnX_qP7S9AfeNx</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2476743335</pqid></control><display><type>article</type><title>Comprehensive profiling of the chemical components and potential markers in raw and processed Cistanche tubulosa by combining ultra-high-performance liquid chromatography coupled with tandem mass spectrometry and MS/MS-based molecular networking</title><source>SpringerLink Journals - AutoHoldings</source><creator>Lei, Huibo ; Zhang, Yuhao ; Zu, Xianpeng ; Ye, Ji ; Liang, Yanlin ; Cheng, Taofang ; Zhang, Weidong</creator><creatorcontrib>Lei, Huibo ; Zhang, Yuhao ; Zu, Xianpeng ; Ye, Ji ; Liang, Yanlin ; Cheng, Taofang ; Zhang, Weidong</creatorcontrib><description>Chinese materia medica processing is a distinguished and unique pharmaceutical technique in traditional Chinese medicine (TCM), which has played an important role in reducing side effects, increasing medical potencies, altering the properties and even changing the curative effects of raw herbs. The efficacy improvement in medicinal plants is mainly caused by changes in the key substances through an optimized processing procedure. Thus, the use of a rapid method for determining suitable chemical markers between raw and processed TCM is critical in order to elucidate how the bioactive compounds influence the clinical effects. In this study, ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry combined with MS/MS-based molecular networking (MN) and a multivariate statistical analysis method is proposed for the first time. This combination was used to identify the complex chemical composition and clarify the changed constituents between raw and processed
Cistanche tubulosa
(
C. tubulosa
). The chemical analysis results demonstrated that a total of 85 compounds were identified in the crude and processed
C. tubulosa
. Moreover, 34 compounds were detected as chemical markers. This systematic research into chemical constituents and chemical markers of crude and processed
C. tubulosa
lays a solid foundation for further study of the quality control of
C. tubulosa
. Moreover, the study provides a new and valuable technical strategy for analyzing chemical components and identifying potential chemical markers for the processing of herbal medicines.
Graphical abstract</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-020-02983-0</identifier><identifier>PMID: 33079212</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Analytical Chemistry ; Bioactive compounds ; Biochemistry ; Celleporina tubulosa ; Characterization and Evaluation of Materials ; Chemical analysis ; Chemical composition ; Chemical compounds ; Chemistry ; Chemistry and Materials Science ; Chinese medicine ; Chromatography ; Composition ; Constituents ; Coupling (molecular) ; Desert flora ; Food Science ; Herbal medicine ; High performance liquid chromatography ; Identification and classification ; Laboratory Medicine ; Liquid chromatography ; Markers ; Mass spectrometry ; Mass spectroscopy ; Materia medica, Vegetable ; Medicinal plants ; Methods ; Monitoring/Environmental Analysis ; Multivariate statistical analysis ; Networking ; Plant extracts ; Quadrupoles ; Quality control ; Research Paper ; Scientific imaging ; Side effects ; Spectra ; Spectroscopy ; Statistical analysis ; Statistical methods ; Traditional Chinese medicine</subject><ispartof>Analytical and bioanalytical chemistry, 2021-01, Vol.413 (1), p.129-139</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-5a993b530113c1934ab7a07313818468f6acac681f4333974362d4b697c45cb23</citedby><cites>FETCH-LOGICAL-c479t-5a993b530113c1934ab7a07313818468f6acac681f4333974362d4b697c45cb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-020-02983-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-020-02983-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33079212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lei, Huibo</creatorcontrib><creatorcontrib>Zhang, Yuhao</creatorcontrib><creatorcontrib>Zu, Xianpeng</creatorcontrib><creatorcontrib>Ye, Ji</creatorcontrib><creatorcontrib>Liang, Yanlin</creatorcontrib><creatorcontrib>Cheng, Taofang</creatorcontrib><creatorcontrib>Zhang, Weidong</creatorcontrib><title>Comprehensive profiling of the chemical components and potential markers in raw and processed Cistanche tubulosa by combining ultra-high-performance liquid chromatography coupled with tandem mass spectrometry and MS/MS-based molecular networking</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>Chinese materia medica processing is a distinguished and unique pharmaceutical technique in traditional Chinese medicine (TCM), which has played an important role in reducing side effects, increasing medical potencies, altering the properties and even changing the curative effects of raw herbs. The efficacy improvement in medicinal plants is mainly caused by changes in the key substances through an optimized processing procedure. Thus, the use of a rapid method for determining suitable chemical markers between raw and processed TCM is critical in order to elucidate how the bioactive compounds influence the clinical effects. In this study, ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry combined with MS/MS-based molecular networking (MN) and a multivariate statistical analysis method is proposed for the first time. This combination was used to identify the complex chemical composition and clarify the changed constituents between raw and processed
Cistanche tubulosa
(
C. tubulosa
). The chemical analysis results demonstrated that a total of 85 compounds were identified in the crude and processed
C. tubulosa
. Moreover, 34 compounds were detected as chemical markers. This systematic research into chemical constituents and chemical markers of crude and processed
C. tubulosa
lays a solid foundation for further study of the quality control of
C. tubulosa
. Moreover, the study provides a new and valuable technical strategy for analyzing chemical components and identifying potential chemical markers for the processing of herbal medicines.
Graphical abstract</description><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Bioactive compounds</subject><subject>Biochemistry</subject><subject>Celleporina tubulosa</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical analysis</subject><subject>Chemical composition</subject><subject>Chemical compounds</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chinese medicine</subject><subject>Chromatography</subject><subject>Composition</subject><subject>Constituents</subject><subject>Coupling (molecular)</subject><subject>Desert flora</subject><subject>Food Science</subject><subject>Herbal medicine</subject><subject>High performance liquid chromatography</subject><subject>Identification and classification</subject><subject>Laboratory Medicine</subject><subject>Liquid chromatography</subject><subject>Markers</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Materia medica, Vegetable</subject><subject>Medicinal plants</subject><subject>Methods</subject><subject>Monitoring/Environmental Analysis</subject><subject>Multivariate statistical analysis</subject><subject>Networking</subject><subject>Plant extracts</subject><subject>Quadrupoles</subject><subject>Quality control</subject><subject>Research Paper</subject><subject>Scientific imaging</subject><subject>Side effects</subject><subject>Spectra</subject><subject>Spectroscopy</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Traditional Chinese medicine</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kktv1TAQhSMEoqXwB1ggS2zYpPUjz2V1xUtqxaKwthxncuPWsVPb6dX94eyZ9JZWIISiKJbmO2cmnpNlbxk9ZZTWZ5FSzqqccopv24icPsuOWcWanFclff54LvhR9irGa0pZ2bDqZXYkBK1bzvhx9nPjpznACC6aOyBz8IOxxm2JH0gagegRJqOVJRo578ClSJTryewTng0WJhVuIERiHAlqdygGryFG6MnGxKQcmpC0dIv1UZFuv3p1xq1dFpuCykezHfMZwuDDhDQQa24X02Pz4CeV_DaoeVxly2zRdGfSSNC2hwm7x0jiDDohCins7we4vDq7vMo7tY4weQt6sSoQB2nnww32fZ29GJSN8Obhe5L9-PTx--ZLfvHt89fN-UWui7pNeanaVnSloIwJzVpRqK5WtBZMNKwpqmaolFa6athQCCHauhAV74uuamtdlLrj4iT7cPDFG7ldICY5majBWuXAL1HyouQlbRhniL7_C732S3A4HVJ1Va8dyidqqyxI4waP96dXU3mOO8ehKt4idfoPCp9-XSZuEXcMfwr4QaCDjzHAIOdgcLF7yahcsyYPWZOYNXmfNUlR9O5h4qWboH-U_A4XAuIARCy5LYSnX_qP7S9AfeNx</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Lei, Huibo</creator><creator>Zhang, Yuhao</creator><creator>Zu, Xianpeng</creator><creator>Ye, Ji</creator><creator>Liang, Yanlin</creator><creator>Cheng, Taofang</creator><creator>Zhang, Weidong</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20210101</creationdate><title>Comprehensive profiling of the chemical components and potential markers in raw and processed Cistanche tubulosa by combining ultra-high-performance liquid chromatography coupled with tandem mass spectrometry and MS/MS-based molecular networking</title><author>Lei, Huibo ; Zhang, Yuhao ; Zu, Xianpeng ; Ye, Ji ; Liang, Yanlin ; Cheng, Taofang ; Zhang, Weidong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-5a993b530113c1934ab7a07313818468f6acac681f4333974362d4b697c45cb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Analytical Chemistry</topic><topic>Bioactive compounds</topic><topic>Biochemistry</topic><topic>Celleporina tubulosa</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemical analysis</topic><topic>Chemical composition</topic><topic>Chemical compounds</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chinese medicine</topic><topic>Chromatography</topic><topic>Composition</topic><topic>Constituents</topic><topic>Coupling (molecular)</topic><topic>Desert flora</topic><topic>Food Science</topic><topic>Herbal medicine</topic><topic>High performance liquid chromatography</topic><topic>Identification and classification</topic><topic>Laboratory Medicine</topic><topic>Liquid chromatography</topic><topic>Markers</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Materia medica, Vegetable</topic><topic>Medicinal plants</topic><topic>Methods</topic><topic>Monitoring/Environmental Analysis</topic><topic>Multivariate statistical analysis</topic><topic>Networking</topic><topic>Plant extracts</topic><topic>Quadrupoles</topic><topic>Quality control</topic><topic>Research Paper</topic><topic>Scientific imaging</topic><topic>Side effects</topic><topic>Spectra</topic><topic>Spectroscopy</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Traditional Chinese medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lei, Huibo</creatorcontrib><creatorcontrib>Zhang, Yuhao</creatorcontrib><creatorcontrib>Zu, Xianpeng</creatorcontrib><creatorcontrib>Ye, Ji</creatorcontrib><creatorcontrib>Liang, Yanlin</creatorcontrib><creatorcontrib>Cheng, Taofang</creatorcontrib><creatorcontrib>Zhang, Weidong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical and bioanalytical chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lei, Huibo</au><au>Zhang, Yuhao</au><au>Zu, Xianpeng</au><au>Ye, Ji</au><au>Liang, Yanlin</au><au>Cheng, Taofang</au><au>Zhang, Weidong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comprehensive profiling of the chemical components and potential markers in raw and processed Cistanche tubulosa by combining ultra-high-performance liquid chromatography coupled with tandem mass spectrometry and MS/MS-based molecular networking</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>413</volume><issue>1</issue><spage>129</spage><epage>139</epage><pages>129-139</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>Chinese materia medica processing is a distinguished and unique pharmaceutical technique in traditional Chinese medicine (TCM), which has played an important role in reducing side effects, increasing medical potencies, altering the properties and even changing the curative effects of raw herbs. The efficacy improvement in medicinal plants is mainly caused by changes in the key substances through an optimized processing procedure. Thus, the use of a rapid method for determining suitable chemical markers between raw and processed TCM is critical in order to elucidate how the bioactive compounds influence the clinical effects. In this study, ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry combined with MS/MS-based molecular networking (MN) and a multivariate statistical analysis method is proposed for the first time. This combination was used to identify the complex chemical composition and clarify the changed constituents between raw and processed
Cistanche tubulosa
(
C. tubulosa
). The chemical analysis results demonstrated that a total of 85 compounds were identified in the crude and processed
C. tubulosa
. Moreover, 34 compounds were detected as chemical markers. This systematic research into chemical constituents and chemical markers of crude and processed
C. tubulosa
lays a solid foundation for further study of the quality control of
C. tubulosa
. Moreover, the study provides a new and valuable technical strategy for analyzing chemical components and identifying potential chemical markers for the processing of herbal medicines.
Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33079212</pmid><doi>10.1007/s00216-020-02983-0</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1618-2642 |
| ispartof | Analytical and bioanalytical chemistry, 2021-01, Vol.413 (1), p.129-139 |
| issn | 1618-2642 1618-2650 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2452508121 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Analysis Analytical Chemistry Bioactive compounds Biochemistry Celleporina tubulosa Characterization and Evaluation of Materials Chemical analysis Chemical composition Chemical compounds Chemistry Chemistry and Materials Science Chinese medicine Chromatography Composition Constituents Coupling (molecular) Desert flora Food Science Herbal medicine High performance liquid chromatography Identification and classification Laboratory Medicine Liquid chromatography Markers Mass spectrometry Mass spectroscopy Materia medica, Vegetable Medicinal plants Methods Monitoring/Environmental Analysis Multivariate statistical analysis Networking Plant extracts Quadrupoles Quality control Research Paper Scientific imaging Side effects Spectra Spectroscopy Statistical analysis Statistical methods Traditional Chinese medicine |
| title | Comprehensive profiling of the chemical components and potential markers in raw and processed Cistanche tubulosa by combining ultra-high-performance liquid chromatography coupled with tandem mass spectrometry and MS/MS-based molecular networking |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T21%3A20%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comprehensive%20profiling%20of%20the%20chemical%20components%20and%20potential%20markers%20in%20raw%20and%20processed%20Cistanche%20tubulosa%20by%20combining%20ultra-high-performance%20liquid%20chromatography%20coupled%20with%20tandem%20mass%20spectrometry%20and%20MS/MS-based%20molecular%20networking&rft.jtitle=Analytical%20and%20bioanalytical%20chemistry&rft.au=Lei,%20Huibo&rft.date=2021-01-01&rft.volume=413&rft.issue=1&rft.spage=129&rft.epage=139&rft.pages=129-139&rft.issn=1618-2642&rft.eissn=1618-2650&rft_id=info:doi/10.1007/s00216-020-02983-0&rft_dat=%3Cgale_proqu%3EA650846629%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2476743335&rft_id=info:pmid/33079212&rft_galeid=A650846629&rfr_iscdi=true |