MTOR suppresses autophagy-mediated production of IL25 in allergic airway inflammation

IntroductionAirway epithelial cells are recognised as an essential controller for the initiation and perpetuation of asthmatic inflammation, yet the detailed mechanisms remain largely unknown. This study aims to investigate the roles and mechanisms of the mechanistic target of rapamycin (MTOR)–autop...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Thorax 2020-12, Vol.75 (12), p.1047-1057
Hauptverfasser:	Li, Wen, Wu, Yinfang, Zhao, Yun, Li, Zhouyang, Chen, Haixia, Dong, Lingling, Liu, Huiwen, Zhang, Min, Wu, Yanping, Zhou, Jiesen, Xiong, Juan, Hu, Yue, Hua, Wen, Zhang, Bin, Qiu, Minzhi, Zhang, Qing-ling, Wei, Chunhua, Wen, Mingchun, Han, Jing, Zhou, Xiaobo, Qiu, Weiliang, Yan, Fugui, Huang, Huaqiong, Ying, Songmin, Choi, Augustine M K, Shen, Huahao, Chen, Zhihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged airway epithelium Airway management Allergens allergic lung disease Animals Asthma Asthma - metabolism Asthma - pathology Asthma - physiopathology asthma mechanisms Autophagy Autophagy - drug effects Cells, Cultured Cytokines Epithelial Cells - metabolism Experiments Female Gene Knockdown Techniques Human subjects Humans Inflammation Inflammation - metabolism Inflammation - pathology Interleukin-13 - metabolism Interleukin-13 - pharmacology Interleukin-17 - biosynthesis Interleukin-33 - metabolism Interleukin-33 - pharmacology Interleukins - metabolism Kinases Laboratories Male Mice Microscopy Microtubule-Associated Proteins - genetics Middle Aged Pathogenesis Proteins Respiratory Mucosa - physiopathology Signal Transduction TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Tuberous Sclerosis Complex 2 Protein - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!