Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study

This is the initial report of results from the AURORA multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience. We focus on n  = 666 participants presenting t...

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Veröffentlicht in:Molecular psychiatry 2021-07, Vol.26 (7), p.3108-3121
Hauptverfasser: Kessler, Ronald C., Ressler, Kerry J., House, Stacey L., Beaudoin, Francesca L., An, Xinming, Stevens, Jennifer S., Zeng, Donglin, Neylan, Thomas C., Linnstaedt, Sarah D., Germine, Laura T., Musey, Paul I., Hendry, Phyllis L., Sheikh, Sophia, Storrow, Alan B., Jones, Christopher W., Punches, Brittany E., Datner, Elizabeth M., Mohiuddin, Kamran, Gentile, Nina T., McGrath, Meghan E., van Rooij, Sanne J., Hudak, Lauren A., Haran, John P., Peak, David A., Domeier, Robert M., Pearson, Claire, Sanchez, Leon D., Rathlev, Niels K., Peacock, William F., Bruce, Steven E., Miller, Mark W., Joormann, Jutta, Barch, Deanna M., Pizzagalli, Diego A., Sheridan, John F., Smoller, Jordan W., Pace, Thaddeus W. W., Harte, Steven E., Elliott, James M., Harnett, Nathaniel G., Lebois, Lauren A. M., Hwang, Irving, Sampson, Nancy A., Koenen, Karestan C., McLean, Samuel A.
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container_end_page 3121
container_issue 7
container_start_page 3108
container_title Molecular psychiatry
container_volume 26
creator Kessler, Ronald C.
Ressler, Kerry J.
House, Stacey L.
Beaudoin, Francesca L.
An, Xinming
Stevens, Jennifer S.
Zeng, Donglin
Neylan, Thomas C.
Linnstaedt, Sarah D.
Germine, Laura T.
Musey, Paul I.
Hendry, Phyllis L.
Sheikh, Sophia
Storrow, Alan B.
Jones, Christopher W.
Punches, Brittany E.
Datner, Elizabeth M.
Mohiuddin, Kamran
Gentile, Nina T.
McGrath, Meghan E.
van Rooij, Sanne J.
Hudak, Lauren A.
Haran, John P.
Peak, David A.
Domeier, Robert M.
Pearson, Claire
Sanchez, Leon D.
Rathlev, Niels K.
Peacock, William F.
Bruce, Steven E.
Miller, Mark W.
Joormann, Jutta
Barch, Deanna M.
Pizzagalli, Diego A.
Sheridan, John F.
Smoller, Jordan W.
Pace, Thaddeus W. W.
Harte, Steven E.
Elliott, James M.
Harnett, Nathaniel G.
Lebois, Lauren A. M.
Hwang, Irving
Sampson, Nancy A.
Koenen, Karestan C.
McLean, Samuel A.
description This is the initial report of results from the AURORA multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience. We focus on n  = 666 participants presenting to EDs following a motor vehicle collision (MVC) and examine associations of participant socio-demographic and participant-reported MVC characteristics with 8-week posttraumatic stress disorder (PTSD) adjusting for pre-MVC PTSD and mediated by peritraumatic symptoms and 2-week acute stress disorder (ASD). Peritraumatic Symptoms, ASD, and PTSD were assessed with self-report scales. Eight-week PTSD prevalence was relatively high (42.0%) and positively associated with participant sex (female), low socioeconomic status (education and income), and several self-report indicators of MVC severity. Most of these associations were entirely mediated by peritraumatic symptoms and, to a lesser degree, ASD, suggesting that the first 2 weeks after trauma may be a uniquely important time period for intervening to prevent and reduce risk of PTSD. This observation, coupled with substantial variation in the relative strength of mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated with more in-depth analyses of the rich and evolving AURORA data.
doi_str_mv 10.1038/s41380-020-00911-3
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M. ; Hwang, Irving ; Sampson, Nancy A. ; Koenen, Karestan C. ; McLean, Samuel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-ea5bf356b205d882cd664852a5e83f4aecc5704ba3bd4359de938fbebe3c74953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/477</topic><topic>692/699/476</topic><topic>Accidents, Traffic</topic><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>Complications</topic><topic>Emergency medical care</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Motor Vehicles</topic><topic>Neurosciences</topic><topic>Pharmacotherapy</topic><topic>Post traumatic stress disorder</topic><topic>Prevalence</topic><topic>Psychiatry</topic><topic>Psychological aspects</topic><topic>Risk factors</topic><topic>Sociodemographics</topic><topic>Statistics</topic><topic>Stress Disorders, Post-Traumatic - epidemiology</topic><topic>Traffic accidents</topic><topic>Trauma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kessler, Ronald C.</creatorcontrib><creatorcontrib>Ressler, Kerry J.</creatorcontrib><creatorcontrib>House, Stacey L.</creatorcontrib><creatorcontrib>Beaudoin, Francesca L.</creatorcontrib><creatorcontrib>An, Xinming</creatorcontrib><creatorcontrib>Stevens, Jennifer S.</creatorcontrib><creatorcontrib>Zeng, Donglin</creatorcontrib><creatorcontrib>Neylan, Thomas C.</creatorcontrib><creatorcontrib>Linnstaedt, Sarah D.</creatorcontrib><creatorcontrib>Germine, Laura T.</creatorcontrib><creatorcontrib>Musey, Paul I.</creatorcontrib><creatorcontrib>Hendry, Phyllis L.</creatorcontrib><creatorcontrib>Sheikh, Sophia</creatorcontrib><creatorcontrib>Storrow, Alan B.</creatorcontrib><creatorcontrib>Jones, Christopher W.</creatorcontrib><creatorcontrib>Punches, Brittany E.</creatorcontrib><creatorcontrib>Datner, Elizabeth M.</creatorcontrib><creatorcontrib>Mohiuddin, Kamran</creatorcontrib><creatorcontrib>Gentile, Nina T.</creatorcontrib><creatorcontrib>McGrath, Meghan E.</creatorcontrib><creatorcontrib>van Rooij, Sanne J.</creatorcontrib><creatorcontrib>Hudak, Lauren A.</creatorcontrib><creatorcontrib>Haran, John P.</creatorcontrib><creatorcontrib>Peak, David A.</creatorcontrib><creatorcontrib>Domeier, Robert M.</creatorcontrib><creatorcontrib>Pearson, Claire</creatorcontrib><creatorcontrib>Sanchez, Leon D.</creatorcontrib><creatorcontrib>Rathlev, Niels K.</creatorcontrib><creatorcontrib>Peacock, William F.</creatorcontrib><creatorcontrib>Bruce, Steven E.</creatorcontrib><creatorcontrib>Miller, Mark W.</creatorcontrib><creatorcontrib>Joormann, Jutta</creatorcontrib><creatorcontrib>Barch, Deanna M.</creatorcontrib><creatorcontrib>Pizzagalli, Diego A.</creatorcontrib><creatorcontrib>Sheridan, John F.</creatorcontrib><creatorcontrib>Smoller, Jordan W.</creatorcontrib><creatorcontrib>Pace, Thaddeus W. 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M.</creatorcontrib><creatorcontrib>Hwang, Irving</creatorcontrib><creatorcontrib>Sampson, Nancy A.</creatorcontrib><creatorcontrib>Koenen, Karestan C.</creatorcontrib><creatorcontrib>McLean, Samuel A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kessler, Ronald C.</au><au>Ressler, Kerry J.</au><au>House, Stacey L.</au><au>Beaudoin, Francesca L.</au><au>An, Xinming</au><au>Stevens, Jennifer S.</au><au>Zeng, Donglin</au><au>Neylan, Thomas C.</au><au>Linnstaedt, Sarah D.</au><au>Germine, Laura T.</au><au>Musey, Paul I.</au><au>Hendry, Phyllis L.</au><au>Sheikh, Sophia</au><au>Storrow, Alan B.</au><au>Jones, Christopher W.</au><au>Punches, Brittany E.</au><au>Datner, Elizabeth M.</au><au>Mohiuddin, Kamran</au><au>Gentile, Nina T.</au><au>McGrath, Meghan E.</au><au>van Rooij, Sanne J.</au><au>Hudak, Lauren A.</au><au>Haran, John P.</au><au>Peak, David A.</au><au>Domeier, Robert M.</au><au>Pearson, Claire</au><au>Sanchez, Leon D.</au><au>Rathlev, Niels K.</au><au>Peacock, William F.</au><au>Bruce, Steven E.</au><au>Miller, Mark W.</au><au>Joormann, Jutta</au><au>Barch, Deanna M.</au><au>Pizzagalli, Diego A.</au><au>Sheridan, John F.</au><au>Smoller, Jordan W.</au><au>Pace, Thaddeus W. W.</au><au>Harte, Steven E.</au><au>Elliott, James M.</au><au>Harnett, Nathaniel G.</au><au>Lebois, Lauren A. M.</au><au>Hwang, Irving</au><au>Sampson, Nancy A.</au><au>Koenen, Karestan C.</au><au>McLean, Samuel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>26</volume><issue>7</issue><spage>3108</spage><epage>3121</epage><pages>3108-3121</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>This is the initial report of results from the AURORA multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience. We focus on n  = 666 participants presenting to EDs following a motor vehicle collision (MVC) and examine associations of participant socio-demographic and participant-reported MVC characteristics with 8-week posttraumatic stress disorder (PTSD) adjusting for pre-MVC PTSD and mediated by peritraumatic symptoms and 2-week acute stress disorder (ASD). Peritraumatic Symptoms, ASD, and PTSD were assessed with self-report scales. Eight-week PTSD prevalence was relatively high (42.0%) and positively associated with participant sex (female), low socioeconomic status (education and income), and several self-report indicators of MVC severity. Most of these associations were entirely mediated by peritraumatic symptoms and, to a lesser degree, ASD, suggesting that the first 2 weeks after trauma may be a uniquely important time period for intervening to prevent and reduce risk of PTSD. This observation, coupled with substantial variation in the relative strength of mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated with more in-depth analyses of the rich and evolving AURORA data.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33077855</pmid><doi>10.1038/s41380-020-00911-3</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-5295-7072</orcidid><orcidid>https://orcid.org/0000-0003-1939-3126</orcidid><orcidid>https://orcid.org/0000-0003-4831-2305</orcidid><orcidid>https://orcid.org/0000-0002-5158-1103</orcidid><orcidid>https://orcid.org/0000-0001-9482-3582</orcidid><orcidid>https://orcid.org/0000-0002-0160-7248</orcidid><orcidid>https://orcid.org/0000-0001-5816-9181</orcidid><orcidid>https://orcid.org/0000-0002-7772-1143</orcidid><orcidid>https://orcid.org/0000-0003-4674-0314</orcidid><orcidid>https://orcid.org/0000-0003-1693-8506</orcidid><orcidid>https://orcid.org/0000-0001-6393-8563</orcidid><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1359-4184
ispartof Molecular psychiatry, 2021-07, Vol.26 (7), p.3108-3121
issn 1359-4184
1476-5578
language eng
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source MEDLINE; Alma/SFX Local Collection
subjects 631/477
692/699/476
Accidents, Traffic
Behavioral Sciences
Biological Psychology
Complications
Emergency medical care
Female
Health aspects
Humans
Longitudinal Studies
Medicine
Medicine & Public Health
Motor Vehicles
Neurosciences
Pharmacotherapy
Post traumatic stress disorder
Prevalence
Psychiatry
Psychological aspects
Risk factors
Sociodemographics
Statistics
Stress Disorders, Post-Traumatic - epidemiology
Traffic accidents
Trauma
title Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study
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