Photoconjugation of an Fc-Specific Peptide Enables Efficient DAR 2 Antibody–Drug Conjugate Formation

Antibody–drug conjugates (ADCs) in current clinical usage have been constructed via the nonspecific conjugation of drugs to antibodies, rendering the manufacturing processes difficult. In this study, a high-affinity IgG Fc-binding peptide equipped with a photoreactive amino acid was developed and su...

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Veröffentlicht in:	Organic letters 2020-11, Vol.22 (21), p.8419-8423
Hauptverfasser:	Lee, TaeJin, Kim, Ju Hwan, Kwon, Se Jeong, Park, Sun Hee, Kim, Jinyoung, Kang, Hyo Jin, Chung, Sang J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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