Harnessing the Power of the Asymmetric Grignard Synthesis of Tertiary Alcohols: Ligand Development and Improved Scope Exemplified by One-Step Gossonorol Synthesis

A series of N-substituted cyclohexyl­diamino­phenolic ligands for the asymmetric Grignard synthesis of tertiary alcohols is reported. The 2,5-dimethylpyrrole-decorated ligand led to improved enantioselectivities and broadened the scope of the methodology. As an exemplar, we report an unprecedented h...

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Veröffentlicht in:	Organic letters 2020-11, Vol.22 (21), p.8198-8203
Hauptverfasser:	Kavanagh, Saranna E, Gilheany, Declan G
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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