Follicle inhibition at the primordial stage without increasing apoptosis, with a combination of everolimus, verapamil

The aim of the present study was to test whether inhibition of ovarian primordial follicles and subsequent activation can be achieved by transient mTOR inhibition. In this preclinical investigation, forty-five female immature Wistar rats were randomized in 5 groups. The control group received subcut...

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Veröffentlicht in:	Molecular biology reports 2020-11, Vol.47 (11), p.8711-8726
Hauptverfasser:	Pargianas, Michail, Kosmas, Ioannis, Papageorgiou, Kyriaki, Kitsou, Chrysoula, Papoudou-Bai, Alexandra, Batistatou, Anna, Markoula, Sofia, Salta, Styliani, Dalkalitsis, Alexandros, Kolibianakis, Stratis, Tarlatzis, Basil C., Georgiou, Ioannis, Michaelidis, Theologos M.
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animal Anatomy Animal Biochemistry Apoptosis Autophagy Biomedical and Life Sciences Cell proliferation Follicle-stimulating hormone Follicles Granulosa cells Histology Life Sciences Morphology Original Article Ovaries Phagocytosis Phosphorylation Progesterone Proliferating cell nuclear antigen Ribosomal protein S6 Ribosomal protein S6 kinase TOR protein Verapamil
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