Metformin ameliorates skeletal muscle atrophy in Grx1 KO mice by regulating intramuscular lipid accumulation and glucose utilization

Skeletal muscle is the largest tissue in the body, and plays a remarkable role in energy and metabolic homeostasis. Disorder in lipid metabolism and glucose utilization could impair the quality and function of skeletal muscle. Glutaredoxin-1 (Grx1) acts as a vital metabolic regulator of redox homeos...

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Veröffentlicht in:	Biochemical and biophysical research communications 2020-12, Vol.533 (4), p.1226-1232
Hauptverfasser:	Yang, Yunfei, Liao, Zhiyin, Xiao, Qian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Female Glucose - metabolism Glucose utilization Glutaredoxins - genetics Grx1 Intramuscular lipid accumulation Lipid Metabolism Metformin - therapeutic use Mice, Inbred C57BL Mice, Knockout Muscle atrophy Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular Atrophy - drug therapy Muscular Atrophy - metabolism Muscular Atrophy - pathology
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